The timed up and go test in idiopathic normal pressure hydrocephalus: a Nationwide Study of 1300 patients
Abstract Background The aim of this study was to describe the outcome measure timed up and go (TUG) in a large, nationwide cohort of patients with idiopathic normal pressure hydrocephalus (iNPH) pre- and post-operatively. Furthermore, to compare the TUG test to the 10-m walk test (10MWT), the iNPH s...
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | Fluids and Barriers of the CNS |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12987-021-00298-5 |
| _version_ | 1798026257724604416 |
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| author | Nina Sundström Johanna Rydja Johan Virhammar Lena Kollén Fredrik Lundin Mats Tullberg |
| author_facet | Nina Sundström Johanna Rydja Johan Virhammar Lena Kollén Fredrik Lundin Mats Tullberg |
| author_sort | Nina Sundström |
| collection | DOAJ |
| description | Abstract Background The aim of this study was to describe the outcome measure timed up and go (TUG) in a large, nationwide cohort of patients with idiopathic normal pressure hydrocephalus (iNPH) pre- and post-operatively. Furthermore, to compare the TUG test to the 10-m walk test (10MWT), the iNPH scale, the modified Rankin scale (mRS) and the Mini Mental State Examination (MMSE), which are commonly applied in clinical assessment of iNPH. Methods Patients with iNPH (n = 1300), registered in the Swedish Hydrocephalus Quality Registry (SHQR), were included. All data were retrieved from the SHQR except the 10MWT, which was collected from patient medical records. Clinical scales were examined pre- and 3 months post-operatively. Data were dichotomised by sex, age, and preoperative TUG time. Results Preoperative TUG values were 19.0 [14.0–26.0] s (median [IQR]) and 23 [18–30] steps. Post-operatively, significant improvements to 14.0 [11.0–20.0] s and 19 [15–25] steps were seen. TUG time and steps were higher in women compared to men (p < 0.001) but there was no sex difference in improvement rate. Worse preoperative TUG and younger age favoured improvement. TUG was highly correlated to the 10MWT, but correlations of post-operative changes were only low to moderate between all scales (r = 0.22–0.61). Conclusions This study establishes the distribution of TUG in iNPH patients and shows that the test captures important clinical features that improve after surgery independent of sex and in all age groups, confirming the clinical value of the TUG test. TUG performance is associated with performance on the 10MWT pre- and post-operatively. However, the weak correlations in post-operative change to the 10MWT and other established outcome measures indicate an additional value of TUG when assessing the effects of shunt surgery. |
| first_indexed | 2024-04-11T18:33:27Z |
| format | Article |
| id | doaj.art-b6f61a1151f2473dbb2169b302085b9f |
| institution | Directory Open Access Journal |
| issn | 2045-8118 |
| language | English |
| last_indexed | 2024-04-11T18:33:27Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Fluids and Barriers of the CNS |
| spelling | doaj.art-b6f61a1151f2473dbb2169b302085b9f2022-12-22T04:09:23ZengBMCFluids and Barriers of the CNS2045-81182022-01-0119111010.1186/s12987-021-00298-5The timed up and go test in idiopathic normal pressure hydrocephalus: a Nationwide Study of 1300 patientsNina Sundström0Johanna Rydja1Johan Virhammar2Lena Kollén3Fredrik Lundin4Mats Tullberg5Department of Radiation Sciences, Radiation Physics, Biomedical Engineering, Umeå UniversityDepartment of Activity and Health, and Department of Biomedical and Clinical Sciences, Linköping UniversityDepartment of Neuroscience, Neurology, Uppsala UniversityDepartment of Neurology, and Department of Biomedical and Clinical Sciences, Linköping UniversityDepartment of Neurology, and Department of Biomedical and Clinical Sciences, Linköping UniversityHydrocephalus Research Unit, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of GothenburgAbstract Background The aim of this study was to describe the outcome measure timed up and go (TUG) in a large, nationwide cohort of patients with idiopathic normal pressure hydrocephalus (iNPH) pre- and post-operatively. Furthermore, to compare the TUG test to the 10-m walk test (10MWT), the iNPH scale, the modified Rankin scale (mRS) and the Mini Mental State Examination (MMSE), which are commonly applied in clinical assessment of iNPH. Methods Patients with iNPH (n = 1300), registered in the Swedish Hydrocephalus Quality Registry (SHQR), were included. All data were retrieved from the SHQR except the 10MWT, which was collected from patient medical records. Clinical scales were examined pre- and 3 months post-operatively. Data were dichotomised by sex, age, and preoperative TUG time. Results Preoperative TUG values were 19.0 [14.0–26.0] s (median [IQR]) and 23 [18–30] steps. Post-operatively, significant improvements to 14.0 [11.0–20.0] s and 19 [15–25] steps were seen. TUG time and steps were higher in women compared to men (p < 0.001) but there was no sex difference in improvement rate. Worse preoperative TUG and younger age favoured improvement. TUG was highly correlated to the 10MWT, but correlations of post-operative changes were only low to moderate between all scales (r = 0.22–0.61). Conclusions This study establishes the distribution of TUG in iNPH patients and shows that the test captures important clinical features that improve after surgery independent of sex and in all age groups, confirming the clinical value of the TUG test. TUG performance is associated with performance on the 10MWT pre- and post-operatively. However, the weak correlations in post-operative change to the 10MWT and other established outcome measures indicate an additional value of TUG when assessing the effects of shunt surgery.https://doi.org/10.1186/s12987-021-00298-5Timed up and goIdiopathic normal pressure hydrocephalusOutcome measure10-m walk testShunt surgeryImprovement rate |
| spellingShingle | Nina Sundström Johanna Rydja Johan Virhammar Lena Kollén Fredrik Lundin Mats Tullberg The timed up and go test in idiopathic normal pressure hydrocephalus: a Nationwide Study of 1300 patients Fluids and Barriers of the CNS Timed up and go Idiopathic normal pressure hydrocephalus Outcome measure 10-m walk test Shunt surgery Improvement rate |
| title | The timed up and go test in idiopathic normal pressure hydrocephalus: a Nationwide Study of 1300 patients |
| title_full | The timed up and go test in idiopathic normal pressure hydrocephalus: a Nationwide Study of 1300 patients |
| title_fullStr | The timed up and go test in idiopathic normal pressure hydrocephalus: a Nationwide Study of 1300 patients |
| title_full_unstemmed | The timed up and go test in idiopathic normal pressure hydrocephalus: a Nationwide Study of 1300 patients |
| title_short | The timed up and go test in idiopathic normal pressure hydrocephalus: a Nationwide Study of 1300 patients |
| title_sort | timed up and go test in idiopathic normal pressure hydrocephalus a nationwide study of 1300 patients |
| topic | Timed up and go Idiopathic normal pressure hydrocephalus Outcome measure 10-m walk test Shunt surgery Improvement rate |
| url | https://doi.org/10.1186/s12987-021-00298-5 |
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