EFFECTS OF ACUTE AND CHRONIC LITHIUM ON MORPHINE-INDUCED ANALGESIA IN MICE BY FORMALIN TEST
In this study, the effects of acute and chronic lithium on nociception induced by formalin and its interactions with morphine-induced analgesia were studied in mice. Formalin test was selected to study nociception. Subcutaneous injection of different doses of morphine (1.5, 3 and 6 mg/kg) induced an...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
1999-03-01
|
| Series: | Acta Medica Iranica |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/1766 |
| _version_ | 1818808332549357568 |
|---|---|
| author | M. Sharifzadeh H.R. Sadeghipour F. Khoshjou A. Khalaj M. AbdoIIahi M.Baradaran |
| author_facet | M. Sharifzadeh H.R. Sadeghipour F. Khoshjou A. Khalaj M. AbdoIIahi M.Baradaran |
| author_sort | M. Sharifzadeh |
| collection | DOAJ |
| description | In this study, the effects of acute and chronic lithium on nociception induced by formalin and its interactions with morphine-induced analgesia were studied in mice. Formalin test was selected to study nociception. Subcutaneous injection of different doses of morphine (1.5, 3 and 6 mg/kg) induced analgesia in a dose dependent manner in both phases of the formalin test. Intraperitoneal administration of different doses of lithium (20, 40, 60 and 80 mg/kg) induced analgesia in late phase but didnot show any significant effect in early phase. Acute administration of lithium (40, 80 mg/kg) increased analgesia induced by morphine (3 mg/kg) in both phases of formalin test. Prctreatment of the animals with chronic lithium (1200 mg/l) for 15 days induced antinociception and increased .the analgesia induced by morphine in both phases of formalin test. It is concluded that administration of acute and chronic lithium can probably affect pain response in both phases of formalin test and interact with morphine-induced antinociception. |
| first_indexed | 2024-12-18T19:39:53Z |
| format | Article |
| id | doaj.art-b6f63138ca4f4ed6b9f72e39aad13b82 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-18T19:39:53Z |
| publishDate | 1999-03-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-b6f63138ca4f4ed6b9f72e39aad13b822022-12-21T20:55:29ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96941999-03-01371EFFECTS OF ACUTE AND CHRONIC LITHIUM ON MORPHINE-INDUCED ANALGESIA IN MICE BY FORMALIN TEST M. Sharifzadeh0 H.R. Sadeghipour1 F. Khoshjou2 A. Khalaj3 M. AbdoIIahi4 M.Baradaran5 In this study, the effects of acute and chronic lithium on nociception induced by formalin and its interactions with morphine-induced analgesia were studied in mice. Formalin test was selected to study nociception. Subcutaneous injection of different doses of morphine (1.5, 3 and 6 mg/kg) induced analgesia in a dose dependent manner in both phases of the formalin test. Intraperitoneal administration of different doses of lithium (20, 40, 60 and 80 mg/kg) induced analgesia in late phase but didnot show any significant effect in early phase. Acute administration of lithium (40, 80 mg/kg) increased analgesia induced by morphine (3 mg/kg) in both phases of formalin test. Prctreatment of the animals with chronic lithium (1200 mg/l) for 15 days induced antinociception and increased .the analgesia induced by morphine in both phases of formalin test. It is concluded that administration of acute and chronic lithium can probably affect pain response in both phases of formalin test and interact with morphine-induced antinociception.https://acta.tums.ac.ir/index.php/acta/article/view/1766 |
| spellingShingle | M. Sharifzadeh H.R. Sadeghipour F. Khoshjou A. Khalaj M. AbdoIIahi M.Baradaran EFFECTS OF ACUTE AND CHRONIC LITHIUM ON MORPHINE-INDUCED ANALGESIA IN MICE BY FORMALIN TEST Acta Medica Iranica |
| title | EFFECTS OF ACUTE AND CHRONIC LITHIUM ON MORPHINE-INDUCED ANALGESIA IN MICE BY FORMALIN TEST |
| title_full | EFFECTS OF ACUTE AND CHRONIC LITHIUM ON MORPHINE-INDUCED ANALGESIA IN MICE BY FORMALIN TEST |
| title_fullStr | EFFECTS OF ACUTE AND CHRONIC LITHIUM ON MORPHINE-INDUCED ANALGESIA IN MICE BY FORMALIN TEST |
| title_full_unstemmed | EFFECTS OF ACUTE AND CHRONIC LITHIUM ON MORPHINE-INDUCED ANALGESIA IN MICE BY FORMALIN TEST |
| title_short | EFFECTS OF ACUTE AND CHRONIC LITHIUM ON MORPHINE-INDUCED ANALGESIA IN MICE BY FORMALIN TEST |
| title_sort | effects of acute and chronic lithium on morphine induced analgesia in mice by formalin test |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/1766 |
| work_keys_str_mv | AT msharifzadeh effectsofacuteandchroniclithiumonmorphineinducedanalgesiainmicebyformalintest AT hrsadeghipour effectsofacuteandchroniclithiumonmorphineinducedanalgesiainmicebyformalintest AT fkhoshjou effectsofacuteandchroniclithiumonmorphineinducedanalgesiainmicebyformalintest AT akhalaj effectsofacuteandchroniclithiumonmorphineinducedanalgesiainmicebyformalintest AT mabdoiiahi effectsofacuteandchroniclithiumonmorphineinducedanalgesiainmicebyformalintest AT mbaradaran effectsofacuteandchroniclithiumonmorphineinducedanalgesiainmicebyformalintest |