Post-traumatic endophthalmitis prophylaxis: a systematic review and meta-analysis
Abstract Purpose The goal of this study is to determine if certain aspects of endophthalmitis prophylaxis strategies are superior to others. Design This investigation is a systematic review and meta-analysis. Methods All studies specifying a type of prophylaxis strategy and resulting rates of endoph...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2022-11-01
|
| Series: | Journal of Ophthalmic Inflammation and Infection |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12348-022-00317-y |
| _version_ | 1811217096851324928 |
|---|---|
| author | Joshua M. Van Swol Walter K. Myers Jonathan A. Beall Miriam M. Atteya Jeffrey P. Blice |
| author_facet | Joshua M. Van Swol Walter K. Myers Jonathan A. Beall Miriam M. Atteya Jeffrey P. Blice |
| author_sort | Joshua M. Van Swol |
| collection | DOAJ |
| description | Abstract Purpose The goal of this study is to determine if certain aspects of endophthalmitis prophylaxis strategies are superior to others. Design This investigation is a systematic review and meta-analysis. Methods All studies specifying a type of prophylaxis strategy and resulting rates of endophthalmitis were included. Time course, method of administration, and antibiotic regimen, and confounding factors were collected and included for meta-regression. Results Time courses greater than 24 h did not significantly improve outcomes. Likewise, intraocular and/or intravenous antibiotic administration methods did not significantly outperform oral administration. No antibiotic regimens performed differently from vancomycin/ ≥ 3rd generation cephalosporin except for ciprofloxacin monotherapy which yielded significantly worse outcomes. Conclusions Future antibiotic strategies should strongly consider the risks of antibiotic treatment > 24 h and administration methods other than the oral antibiotic forms. In addition, providers should be wary of using ciprofloxacin monotherapy for endophthalmitis prophylaxis when treating open globe injuries. |
| first_indexed | 2024-04-12T06:49:25Z |
| format | Article |
| id | doaj.art-b6f6408a333843dd84734767acc303ee |
| institution | Directory Open Access Journal |
| issn | 1869-5760 |
| language | English |
| last_indexed | 2024-04-12T06:49:25Z |
| publishDate | 2022-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of Ophthalmic Inflammation and Infection |
| spelling | doaj.art-b6f6408a333843dd84734767acc303ee2022-12-22T03:43:26ZengSpringerOpenJournal of Ophthalmic Inflammation and Infection1869-57602022-11-011211910.1186/s12348-022-00317-yPost-traumatic endophthalmitis prophylaxis: a systematic review and meta-analysisJoshua M. Van Swol0Walter K. Myers1Jonathan A. Beall2Miriam M. Atteya3Jeffrey P. Blice4College of Medicine, Medical University of South CarolinaCollege of Medicine, Medical University of South CarolinaDepartment of Public Health Sciences, Medical University of South CarolinaCollege of Medicine, Medical University of South CarolinaDepartment of Ophthalmology-Vitreoretinal Surgery, Medical University of South CarolinaAbstract Purpose The goal of this study is to determine if certain aspects of endophthalmitis prophylaxis strategies are superior to others. Design This investigation is a systematic review and meta-analysis. Methods All studies specifying a type of prophylaxis strategy and resulting rates of endophthalmitis were included. Time course, method of administration, and antibiotic regimen, and confounding factors were collected and included for meta-regression. Results Time courses greater than 24 h did not significantly improve outcomes. Likewise, intraocular and/or intravenous antibiotic administration methods did not significantly outperform oral administration. No antibiotic regimens performed differently from vancomycin/ ≥ 3rd generation cephalosporin except for ciprofloxacin monotherapy which yielded significantly worse outcomes. Conclusions Future antibiotic strategies should strongly consider the risks of antibiotic treatment > 24 h and administration methods other than the oral antibiotic forms. In addition, providers should be wary of using ciprofloxacin monotherapy for endophthalmitis prophylaxis when treating open globe injuries.https://doi.org/10.1186/s12348-022-00317-yOpen globePost-traumaticEndophthalmitisMeta-analysisSystematic reviewProphylaxis |
| spellingShingle | Joshua M. Van Swol Walter K. Myers Jonathan A. Beall Miriam M. Atteya Jeffrey P. Blice Post-traumatic endophthalmitis prophylaxis: a systematic review and meta-analysis Journal of Ophthalmic Inflammation and Infection Open globe Post-traumatic Endophthalmitis Meta-analysis Systematic review Prophylaxis |
| title | Post-traumatic endophthalmitis prophylaxis: a systematic review and meta-analysis |
| title_full | Post-traumatic endophthalmitis prophylaxis: a systematic review and meta-analysis |
| title_fullStr | Post-traumatic endophthalmitis prophylaxis: a systematic review and meta-analysis |
| title_full_unstemmed | Post-traumatic endophthalmitis prophylaxis: a systematic review and meta-analysis |
| title_short | Post-traumatic endophthalmitis prophylaxis: a systematic review and meta-analysis |
| title_sort | post traumatic endophthalmitis prophylaxis a systematic review and meta analysis |
| topic | Open globe Post-traumatic Endophthalmitis Meta-analysis Systematic review Prophylaxis |
| url | https://doi.org/10.1186/s12348-022-00317-y |
| work_keys_str_mv | AT joshuamvanswol posttraumaticendophthalmitisprophylaxisasystematicreviewandmetaanalysis AT walterkmyers posttraumaticendophthalmitisprophylaxisasystematicreviewandmetaanalysis AT jonathanabeall posttraumaticendophthalmitisprophylaxisasystematicreviewandmetaanalysis AT miriammatteya posttraumaticendophthalmitisprophylaxisasystematicreviewandmetaanalysis AT jeffreypblice posttraumaticendophthalmitisprophylaxisasystematicreviewandmetaanalysis |