Dominant negative mutant Cyclin T1 proteins inhibit HIV transcription by specifically degrading Tat

Dominant negative mutant Cyclin T1 proteins inhibit HIV transcription by specifically degrading Tat

<p>Abstract</p> <p>Background</p> <p>The positive transcription elongation factor b (P-TEFb) is an essential cellular co-factor for the transcription of the human immunodeficiency virus type 1 (HIV-1). The cyclin T1 (CycT1) subunit of P-TEFb associates with a viral prot...

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Bibliographic Details
Main Authors: Okamoto Takashi, Geyer Matthias, Schulte Antje, Nojima Masanori, Jadlowsky Julie K, Fujinaga Koh
Format: Article
Language:English
Published: BMC 2008-07-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/5/1/63

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