Glycogen synthase kinase 3ß functions as a positive effector in the WNK signaling pathway.
The with no lysine (WNK) protein kinase family is conserved among many species. Some mutations in human WNK gene are associated with pseudohypoaldosteronism type II, a form of hypertension, and hereditary sensory and autonomic neuropathy type 2A. In kidney, WNK regulates the activity of STE20/SPS1-r...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5832235?pdf=render |
| _version_ | 1818137904752361472 |
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| author | Atsushi Sato Hiroshi Shibuya |
| author_facet | Atsushi Sato Hiroshi Shibuya |
| author_sort | Atsushi Sato |
| collection | DOAJ |
| description | The with no lysine (WNK) protein kinase family is conserved among many species. Some mutations in human WNK gene are associated with pseudohypoaldosteronism type II, a form of hypertension, and hereditary sensory and autonomic neuropathy type 2A. In kidney, WNK regulates the activity of STE20/SPS1-related, proline alanine-rich kinase and/or oxidative-stress responsive 1, which in turn regulate ion co-transporters. The misregulation of this pathway is involved in the pathogenesis of pseudohypoaldosteronism type II. In the neural system, WNK is involved in the specification of the cholinergic neuron, but the pathogenesis of hereditary sensory and autonomic neuropathy type 2A is still unknown. To better understand the WNK pathway, we isolated WNK-associated genes using Drosophila. We identified Glycogen synthase kinase 3ß (GSK3ß)/Shaggy (Sgg) as a candidate gene that was shown to interact with the WNK signaling pathway in both Drosophila and mammalian cells. Furthermore, GSK3ß was involved in neural specification downstream of WNK. These results suggest that GSK3ß/Sgg functions as a positive effector in the WNK signaling pathway. |
| first_indexed | 2024-12-11T10:03:43Z |
| format | Article |
| id | doaj.art-b6f8bdc1c3a64ee1bb21db15601dcfdf |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T10:03:43Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj.art-b6f8bdc1c3a64ee1bb21db15601dcfdf2022-12-22T01:12:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01133e019320410.1371/journal.pone.0193204Glycogen synthase kinase 3ß functions as a positive effector in the WNK signaling pathway.Atsushi SatoHiroshi ShibuyaThe with no lysine (WNK) protein kinase family is conserved among many species. Some mutations in human WNK gene are associated with pseudohypoaldosteronism type II, a form of hypertension, and hereditary sensory and autonomic neuropathy type 2A. In kidney, WNK regulates the activity of STE20/SPS1-related, proline alanine-rich kinase and/or oxidative-stress responsive 1, which in turn regulate ion co-transporters. The misregulation of this pathway is involved in the pathogenesis of pseudohypoaldosteronism type II. In the neural system, WNK is involved in the specification of the cholinergic neuron, but the pathogenesis of hereditary sensory and autonomic neuropathy type 2A is still unknown. To better understand the WNK pathway, we isolated WNK-associated genes using Drosophila. We identified Glycogen synthase kinase 3ß (GSK3ß)/Shaggy (Sgg) as a candidate gene that was shown to interact with the WNK signaling pathway in both Drosophila and mammalian cells. Furthermore, GSK3ß was involved in neural specification downstream of WNK. These results suggest that GSK3ß/Sgg functions as a positive effector in the WNK signaling pathway.http://europepmc.org/articles/PMC5832235?pdf=render |
| spellingShingle | Atsushi Sato Hiroshi Shibuya Glycogen synthase kinase 3ß functions as a positive effector in the WNK signaling pathway. PLoS ONE |
| title | Glycogen synthase kinase 3ß functions as a positive effector in the WNK signaling pathway. |
| title_full | Glycogen synthase kinase 3ß functions as a positive effector in the WNK signaling pathway. |
| title_fullStr | Glycogen synthase kinase 3ß functions as a positive effector in the WNK signaling pathway. |
| title_full_unstemmed | Glycogen synthase kinase 3ß functions as a positive effector in the WNK signaling pathway. |
| title_short | Glycogen synthase kinase 3ß functions as a positive effector in the WNK signaling pathway. |
| title_sort | glycogen synthase kinase 3ss functions as a positive effector in the wnk signaling pathway |
| url | http://europepmc.org/articles/PMC5832235?pdf=render |
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