Conifers Phytochemicals: A Valuable Forest with Therapeutic Potential
Conifers have long been recognized for their therapeutic potential in different disorders. Alkaloids, terpenes and polyphenols are the most abundant naturally occurring phytochemicals in these plants. Here, we provide an overview of the phytochemistry and related commercial products obtained from co...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/10/3005 |
| _version_ | 1797533635655499776 |
|---|---|
| author | Kanchan Bhardwaj Ana Sanches Silva Maria Atanassova Rohit Sharma Eugenie Nepovimova Kamil Musilek Ruchi Sharma Mousa A. Alghuthaymi Daljeet Singh Dhanjal Marcello Nicoletti Bechan Sharma Navneet Kumar Upadhyay Natália Cruz-Martins Prerna Bhardwaj Kamil Kuča |
| author_facet | Kanchan Bhardwaj Ana Sanches Silva Maria Atanassova Rohit Sharma Eugenie Nepovimova Kamil Musilek Ruchi Sharma Mousa A. Alghuthaymi Daljeet Singh Dhanjal Marcello Nicoletti Bechan Sharma Navneet Kumar Upadhyay Natália Cruz-Martins Prerna Bhardwaj Kamil Kuča |
| author_sort | Kanchan Bhardwaj |
| collection | DOAJ |
| description | Conifers have long been recognized for their therapeutic potential in different disorders. Alkaloids, terpenes and polyphenols are the most abundant naturally occurring phytochemicals in these plants. Here, we provide an overview of the phytochemistry and related commercial products obtained from conifers. The pharmacological actions of different phytochemicals present in conifers against bacterial and fungal infections, cancer, diabetes and cardiovascular diseases are also reviewed. Data obtained from experimental and clinical studies performed to date clearly underline that such compounds exert promising antioxidant effects, being able to inhibit cell damage, cancer growth, inflammation and the onset of neurodegenerative diseases. Therefore, an attempt has been made with the intent to highlight the importance of conifer-derived extracts for pharmacological purposes, with the support of relevant in vitro and in vivo experimental data. In short, this review comprehends the information published to date related to conifers’ phytochemicals and illustrates their potential role as drugs. |
| first_indexed | 2024-03-10T11:17:24Z |
| format | Article |
| id | doaj.art-b6f9b8f558024775b95c0bda8f3ab861 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T11:17:24Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b6f9b8f558024775b95c0bda8f3ab8612023-11-21T20:19:11ZengMDPI AGMolecules1420-30492021-05-012610300510.3390/molecules26103005Conifers Phytochemicals: A Valuable Forest with Therapeutic PotentialKanchan Bhardwaj0Ana Sanches Silva1Maria Atanassova2Rohit Sharma3Eugenie Nepovimova4Kamil Musilek5Ruchi Sharma6Mousa A. Alghuthaymi7Daljeet Singh Dhanjal8Marcello Nicoletti9Bechan Sharma10Navneet Kumar Upadhyay11Natália Cruz-Martins12Prerna Bhardwaj13Kamil Kuča14School of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, IndiaNational Institute for Agricultural and Veterinary Research (INIAV), I.P., Vairão, 4485-655 Vila do Conde, PortugalScientific Consulting, Chemical Engineering, University of Chemical Technology and Metallurgy, 1734 Sofia, BulgariaDepartment of Rasashastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, IndiaDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech RepublicDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech RepublicSchool of Bioengineering & Food Technology, Shoolini University of Biotechnology and Management Sciences, Solan 173229, IndiaBiology Department, Science and Humanities College, Shaqra University, Alquwayiyah 11971, Saudi ArabiaSchool of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, IndiaDepartment of Environmental Biology, Sapienza University of Rome, Square Aldo Moro, 5, 00185 Rome, ItalyDepartment of Biochemistry, University of Allahabad, Allahabad 211002, IndiaSchool of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, IndiaFaculty of Medicine, University of Porto, 4200-319 Porto, PortugalSchool of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, IndiaDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech RepublicConifers have long been recognized for their therapeutic potential in different disorders. Alkaloids, terpenes and polyphenols are the most abundant naturally occurring phytochemicals in these plants. Here, we provide an overview of the phytochemistry and related commercial products obtained from conifers. The pharmacological actions of different phytochemicals present in conifers against bacterial and fungal infections, cancer, diabetes and cardiovascular diseases are also reviewed. Data obtained from experimental and clinical studies performed to date clearly underline that such compounds exert promising antioxidant effects, being able to inhibit cell damage, cancer growth, inflammation and the onset of neurodegenerative diseases. Therefore, an attempt has been made with the intent to highlight the importance of conifer-derived extracts for pharmacological purposes, with the support of relevant in vitro and in vivo experimental data. In short, this review comprehends the information published to date related to conifers’ phytochemicals and illustrates their potential role as drugs.https://www.mdpi.com/1420-3049/26/10/3005conifersphytoconstituentoxidative stressantibacterialanti-inflammatoryanticancer |
| spellingShingle | Kanchan Bhardwaj Ana Sanches Silva Maria Atanassova Rohit Sharma Eugenie Nepovimova Kamil Musilek Ruchi Sharma Mousa A. Alghuthaymi Daljeet Singh Dhanjal Marcello Nicoletti Bechan Sharma Navneet Kumar Upadhyay Natália Cruz-Martins Prerna Bhardwaj Kamil Kuča Conifers Phytochemicals: A Valuable Forest with Therapeutic Potential Molecules conifers phytoconstituent oxidative stress antibacterial anti-inflammatory anticancer |
| title | Conifers Phytochemicals: A Valuable Forest with Therapeutic Potential |
| title_full | Conifers Phytochemicals: A Valuable Forest with Therapeutic Potential |
| title_fullStr | Conifers Phytochemicals: A Valuable Forest with Therapeutic Potential |
| title_full_unstemmed | Conifers Phytochemicals: A Valuable Forest with Therapeutic Potential |
| title_short | Conifers Phytochemicals: A Valuable Forest with Therapeutic Potential |
| title_sort | conifers phytochemicals a valuable forest with therapeutic potential |
| topic | conifers phytoconstituent oxidative stress antibacterial anti-inflammatory anticancer |
| url | https://www.mdpi.com/1420-3049/26/10/3005 |
| work_keys_str_mv | AT kanchanbhardwaj conifersphytochemicalsavaluableforestwiththerapeuticpotential AT anasanchessilva conifersphytochemicalsavaluableforestwiththerapeuticpotential AT mariaatanassova conifersphytochemicalsavaluableforestwiththerapeuticpotential AT rohitsharma conifersphytochemicalsavaluableforestwiththerapeuticpotential AT eugenienepovimova conifersphytochemicalsavaluableforestwiththerapeuticpotential AT kamilmusilek conifersphytochemicalsavaluableforestwiththerapeuticpotential AT ruchisharma conifersphytochemicalsavaluableforestwiththerapeuticpotential AT mousaaalghuthaymi conifersphytochemicalsavaluableforestwiththerapeuticpotential AT daljeetsinghdhanjal conifersphytochemicalsavaluableforestwiththerapeuticpotential AT marcellonicoletti conifersphytochemicalsavaluableforestwiththerapeuticpotential AT bechansharma conifersphytochemicalsavaluableforestwiththerapeuticpotential AT navneetkumarupadhyay conifersphytochemicalsavaluableforestwiththerapeuticpotential AT nataliacruzmartins conifersphytochemicalsavaluableforestwiththerapeuticpotential AT prernabhardwaj conifersphytochemicalsavaluableforestwiththerapeuticpotential AT kamilkuca conifersphytochemicalsavaluableforestwiththerapeuticpotential |