In vivo fluctuation of Tax, Foxp3, CTLA-4, and GITR mRNA expression in CD4+CD25+ T cells of patients with human T-lymphotropic virus type 1-associated myelopathy

In vivo fluctuation of Tax, Foxp3, CTLA-4, and GITR mRNA expression in CD4+CD25+ T cells of patients with human T-lymphotropic virus type 1-associated myelopathy

HTLV-1 Tax expression exerts an inhibitory effect on the Foxp3 transcription factor in CD4+CD25+ T-regulatory cells (Treg). For a better understanding of the role of Tax mRNA in the gene expression of cellular markers we measured Tax, Foxp3, CTLA-4, GITR, TGF-β, and IL-10 mRNA in Treg cells...

Full description

Bibliographic Details
Main Authors:	E. Ramirez, L. Cartier, L. Rodriguez, C. Alberti, M.A. Valenzuela
Format:	Article
Language:	English
Published:	Associação Brasileira de Divulgação Científica 2010-11-01
Series:	Brazilian Journal of Medical and Biological Research
Subjects:	HTLV-1-associated myelopathy Tax Foxp3 CTLA-4 GITR mRNA expression
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100014

Similar Items

Expansion of CD4+CD25-GITR+ regulatory T-cell subset in the peripheral blood of patients with primary Sjögren's syndrome: correlation with disease activity
by: R. Gerli, et al.
Published: (2012-12-01)

Co-expression of HBZ, TAX and FOXp3 and HTLV-1-associated myelopathy/ tropical spastic paraparesis development in HTLV-1-infected individuals: A systematic review
by: Ana Carolina Marinho Monteiro Lima, et al.
Published: (2021-01-01)

FOXP3, CTLA-4 & IL-10 genes expression in patients with laryngeal cancer and corresponding metastases
by: Alireza Bolkheir, et al.
Published: (2013-09-01)

Effects of Danazol on Clinical Improvement of Patients with Human T-cell Lymphotropic Virus Type I Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP ): A Placebo-Controlled Clinical Trial
by: Reza Boostani, et al.
Published: (2013-03-01)

CTLA4+CD4+CXCR5−FOXP3+ T cells associate with unfavorable outcome in patients with chronic HBV infection
by: Chunhua Wen, et al.
Published: (2023-01-01)

A comparative study of human T-cell lymphotropic virus-associated myelopathy in HIV-positive and HIV-negative patients in KwaZulu-Natal
by: Hoosain F. Paruk, et al.
Published: (2017-12-01)

Human T-cell lymphotropic virus type I (HTLV-I) proviral DNA viral load among asymptomatic patients and patients with HTLV-I-associated myelopathy/tropical spastic paraparesis
by: P.A. Montanheiro, et al.
Published: (2005-11-01)

Exploring the clinical significance of IL-38 correlation with PD-1, CTLA-4, and FOXP3 in colorectal cancer draining lymph nodes
by: Liuhong Yuan, et al.
Published: (2024-03-01)

The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses
by: Isabel eBarao
Published: (2013-01-01)

Human T-cell lymphotropic virus-1 infection: three infected generations in the same family
by: Marcela Sena Teixeira Mendes, et al.

GITR ligand fusion protein agonist enhances the tumor antigen–specific CD8 T-cell response and leads to long-lasting memory
by: Nick M. Durham, et al.
Published: (2017-06-01)

Effectiveness of Soluble CTLA-4-Fc in the Inhibition of Bone Marrow T-Cell Activation in Context of Indoleamine 2.3-Dioxygenase (IDO) and CD4+Foxp3+ Treg Induction
by: Massalska M, et al.
Published: (2022-12-01)

Glucocorticoid-induced TNF receptor family related protein ligand [GITR-L] is requisite for optimal functioning of regulatory CD4+ T cells.
by: Gongxian eLiao, et al.
Published: (2014-02-01)

Characterizing Foxp3+ and Foxp3- T cells in the homeostatic state and after allo-activation: resting CD4+Foxp3+ Tregs have molecular characteristics of activated T cells
by: Zilei Liu, et al.
Published: (2024-01-01)

CD4+ T Cell Fate Decisions Are Stochastic, Precede Cell Division, Depend on GITR Co-Stimulation, and Are Associated With Uropodium Development
by: Stephen P. Cobbold, et al.
Published: (2018-06-01)

Addressing the Elephant in the Immunotherapy Room: Effector T-Cell Priming versus Depletion of Regulatory T-Cells by Anti-CTLA-4 Therapy
by: Megan M Y Hong, et al.
Published: (2022-03-01)

Neuroimmunology of Human T-Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis
by: Satoshi Nozuma, et al.
Published: (2019-04-01)

Experimental HTLV-I and associated myelopathy
by: CARLOS M. DE CASTRO COSTA, et al.
Published: (1998-09-01)

Pulmonary involvement in patients with HTLV-I associated myelopathy Comprometimento pulmonar em pacientes com mielopatia associada ao HTLV-I
by: Kilma Mattos, et al.
Published: (1995-12-01)

Pregnancy complicated by HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP): a case report
by: Hiroshi Mori, et al.
Published: (2021-07-01)

MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential
by: Natalie J. Tigue, et al.
Published: (2017-03-01)

GITR Promotes the Polarization of TFH-Like Cells in Helicobacter pylori-Positive Gastritis
by: Siqi Ming, et al.
Published: (2021-09-01)

CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment
by: Musleh M Muthana, et al.
Published: (2023-12-01)

Atypical TNF-TNFR superfamily binding interface in the GITR-GITRL complex for T cell activation
by: Min Zhao, et al.
Published: (2021-09-01)

Anti-glucocorticoid-induced Tumor Necrosis Factor–Related Protein (GITR) Therapy Overcomes Radiation-Induced Treg Immunosuppression and Drives Abscopal Effects
by: Jonathan E. Schoenhals, et al.
Published: (2018-09-01)

CD86 Is a Selective CD28 Ligand Supporting FoxP3+ Regulatory T Cell Homeostasis in the Presence of High Levels of CTLA-4
by: Neil Halliday, et al.
Published: (2020-12-01)

HTLV-I associated myelopathy in the northern region of Brazil (Belém-Pará): serological and clinical features of three cases
by: Ricardo Ishak, et al.
Published: (2002-06-01)

Magnetic resonance imaging in HTLV-I associated myelopathy Ressonância magnética na mielopatia associada ao HTLV-I
by: Aílton Melo, et al.
Published: (1993-09-01)

Dermatologic Manifestations in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis
by: Reza Boostani, et al.
Published: (2019-05-01)

The intracellular portion of GITR enhances NGF-promoted neurite growth through an inverse modulation of Erk and NF-κB signalling
by: Laura McKelvey, et al.
Published: (2012-08-01)

Late presentation of human T-lymphotropic virus type 1 infection in Spain reflects suboptimal testing strategies
by: Carmen de Mendoza, et al.
Published: (2022-09-01)

Alteration of CD4CD25Foxp3 T cell level in Kawasaki disease
by: Su Ye Sohn, et al.
Published: (2011-04-01)

Altered Frequencies of CD4+ CD25+ Foxp3+ and CD8+ CD25+ Foxp3+ Regulatory T Cells in Pre-eclampsia
by: Maryam Zare, et al.
Published: (2018-12-01)

GITR and TIGIT immunotherapy provokes divergent multicellular responses in the tumor microenvironment of gastrointestinal cancers
by: Anuja Sathe, et al.
Published: (2023-11-01)

High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1
by: J. Primo, et al.
Published: (2009-08-01)

EZH1/2 dual inhibitors suppress HTLV-1-infected cell proliferation and hyperimmune response in HTLV-1-associated myelopathy
by: Akihito Koseki, et al.
Published: (2023-06-01)

Combination with Toll-like receptor 4 (TLR4) agonist reverses GITR agonism mediated M2 polarization of macrophage in Hepatocellular carcinoma
by: Caixu Pan, et al.
Published: (2022-12-01)

A Study of CD4+Foxp3+Treg and CD8+Foxp3+Treg Cells in Patients with Rheumatoid Arthritis
by: Mahtab Tapak, et al.
Published: (2011-11-01)

EVALUATION OF THE CONTENT OF CD4+CD25+CD127LOW REGULATORY T CELLS AND THEIR FUNCTIONAL STATUS ACCORDING TO THE EXPRESSION OF CTLA-4 AND CD39 MOLECULES IN PATIENTS WITH RHEUMATOID ARTHRITIS
by: G. A. Zhulai, et al.
Published: (2014-06-01)

Sequence and phylogenetic analysis of human T cell lymphotropic virus type 1 from Tumaco, Colombia
by: Norman Balcázar, et al.
Published: (2003-07-01)