Possible algorithms for determining adverse reactions caused by food supplements in Romania
Introduction. The advertising of food supplements on various media channels or in specialty stores with natural products and other places, as well as the lack of informative and educational programs for the population upon side effects and the interaction of food supplements with food and drugs, hav...
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| Format: | Article |
| Language: | English |
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Asociatia de Biosiguranta si Biosecuritate
2021-10-01
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| Series: | One Health & Risk Management |
| Subjects: | |
| Online Access: | https://journal.ohrm.bba.md/index.php/journal-ohrm-bba-md/article/view/155/230 |
| _version_ | 1811330544317759488 |
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| author | Irina Mihaela MATRAN Daniela Lucia MUNTEAN Cristina NICULAS Roxana Maria MARTIN-HADMAS Monica TARCEA |
| author_facet | Irina Mihaela MATRAN Daniela Lucia MUNTEAN Cristina NICULAS Roxana Maria MARTIN-HADMAS Monica TARCEA |
| author_sort | Irina Mihaela MATRAN |
| collection | DOAJ |
| description | Introduction. The advertising of food supplements on various media channels or in specialty stores with natural products and other places, as well as the lack of informative and educational programs for the population upon side effects and the interaction of food supplements with food and drugs, have led to the development of uncontrolled marketing of these products.
Material and methods. PubMed, ResearchGate and EUR-Lex databases were analyzed during 2015-2021, based on search criteria based on: adverse reactions, ingredient new food, food supplements, algorithms.
Results. Certain dietary supplements can cause multiple side effects, such as: impaired platelet function by decreased platelet aggregation, gastrointestinal side effects (diarrhea, vomiting), decreased wound healing/epithelialization, bacterial or fungal sepsis, most common in patients older. Herbal resources such as Aloe vera, Matricaria recutita, Taraxacum officinale and others, can cause dermatological side effects and inhibit the elimination of dermatological drugs metabolised by cytochrome P-450 (e.g. terbinafine). Matricaria recutita, Allium sativum, Mentha piperita L. and others, inhibit the enzyme CYP2C9. Another enzyme with a role in the metabolism of dermatological drugs and which is inhibited by plant resources is CYP3A4.
Conclusions. It is imperative to legislate the reporting of adverse reactions caused by food supplements, including their interaction with food or drugs. |
| first_indexed | 2024-04-13T16:03:42Z |
| format | Article |
| id | doaj.art-b6fc1e8d0dd14889be701322bd2c526d |
| institution | Directory Open Access Journal |
| issn | 2887-3458 2587-3466 |
| language | English |
| last_indexed | 2024-04-13T16:03:42Z |
| publishDate | 2021-10-01 |
| publisher | Asociatia de Biosiguranta si Biosecuritate |
| record_format | Article |
| series | One Health & Risk Management |
| spelling | doaj.art-b6fc1e8d0dd14889be701322bd2c526d2022-12-22T02:40:27ZengAsociatia de Biosiguranta si BiosecuritateOne Health & Risk Management2887-34582587-34662021-10-012442710.38045/ohrm.2021.4.01Possible algorithms for determining adverse reactions caused by food supplements in RomaniaIrina Mihaela MATRAN0https://orcid.org/0000-0001-5491-0796Daniela Lucia MUNTEAN1https://orcid.org/0000-0002-6263-0708Cristina NICULAS2https://orcid.org/0000-0003-2879-5813Roxana Maria MARTIN-HADMAS3https://orcid.org/0000-0003-1499-5398Monica TARCEA4https://orcid.org/0000-0001-7299-118XUniversity of Medicine, Pharmacy, Science and Technology „George Emil Palade”, Tirgu Mures, RomaniaUniversity of Medicine, Pharmacy, Science and Technology „George Emil Palade”, Tirgu Mures, RomaniaRichter Pharmacy no 7, Cluj-Napoca, RomaniaUniversity of Medicine, Pharmacy, Science and Technology „George Emil Palade”, Tirgu Mures, RomaniaUniversity of Medicine, Pharmacy, Science and Technology „George Emil Palade”, Tirgu Mures, RomaniaIntroduction. The advertising of food supplements on various media channels or in specialty stores with natural products and other places, as well as the lack of informative and educational programs for the population upon side effects and the interaction of food supplements with food and drugs, have led to the development of uncontrolled marketing of these products. Material and methods. PubMed, ResearchGate and EUR-Lex databases were analyzed during 2015-2021, based on search criteria based on: adverse reactions, ingredient new food, food supplements, algorithms. Results. Certain dietary supplements can cause multiple side effects, such as: impaired platelet function by decreased platelet aggregation, gastrointestinal side effects (diarrhea, vomiting), decreased wound healing/epithelialization, bacterial or fungal sepsis, most common in patients older. Herbal resources such as Aloe vera, Matricaria recutita, Taraxacum officinale and others, can cause dermatological side effects and inhibit the elimination of dermatological drugs metabolised by cytochrome P-450 (e.g. terbinafine). Matricaria recutita, Allium sativum, Mentha piperita L. and others, inhibit the enzyme CYP2C9. Another enzyme with a role in the metabolism of dermatological drugs and which is inhibited by plant resources is CYP3A4. Conclusions. It is imperative to legislate the reporting of adverse reactions caused by food supplements, including their interaction with food or drugs.https://journal.ohrm.bba.md/index.php/journal-ohrm-bba-md/article/view/155/230nutrivigilencealgorithmsfood supplementsside effects. |
| spellingShingle | Irina Mihaela MATRAN Daniela Lucia MUNTEAN Cristina NICULAS Roxana Maria MARTIN-HADMAS Monica TARCEA Possible algorithms for determining adverse reactions caused by food supplements in Romania One Health & Risk Management nutrivigilence algorithms food supplements side effects. |
| title | Possible algorithms for determining adverse reactions caused by food supplements in Romania |
| title_full | Possible algorithms for determining adverse reactions caused by food supplements in Romania |
| title_fullStr | Possible algorithms for determining adverse reactions caused by food supplements in Romania |
| title_full_unstemmed | Possible algorithms for determining adverse reactions caused by food supplements in Romania |
| title_short | Possible algorithms for determining adverse reactions caused by food supplements in Romania |
| title_sort | possible algorithms for determining adverse reactions caused by food supplements in romania |
| topic | nutrivigilence algorithms food supplements side effects. |
| url | https://journal.ohrm.bba.md/index.php/journal-ohrm-bba-md/article/view/155/230 |
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