Adsorption of SARS CoV-2 spike proteins on various functionalized surfaces correlates with the high transmissibility of Delta and Omicron variants
The SARS-CoV-2 virus emerged at the end of 2019 and rapidly developed several mutated variants, specifically the Delta and Omicron, which demonstrate higher transmissibility and escalating infection cases worldwide. The dominant transmission pathway of this virus is via human-to-human contact and ae...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006422000631 |
| _version_ | 1811244527639330816 |
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| author | Daniela Dobrynin Iryna Polishchuk Lotan Portal Ivan Zlotver Alejandro Sosnik Boaz Pokroy |
| author_facet | Daniela Dobrynin Iryna Polishchuk Lotan Portal Ivan Zlotver Alejandro Sosnik Boaz Pokroy |
| author_sort | Daniela Dobrynin |
| collection | DOAJ |
| description | The SARS-CoV-2 virus emerged at the end of 2019 and rapidly developed several mutated variants, specifically the Delta and Omicron, which demonstrate higher transmissibility and escalating infection cases worldwide. The dominant transmission pathway of this virus is via human-to-human contact and aerosols which once inhaled interact with the mucosal tissue, but another possible route is through contact with surfaces contaminated with SARS-CoV-2, often exhibiting long-term survival. Here we compare the adsorption capacities of the S1 and S2 subunits of the spike (S) protein from the original variant to that of the S1 subunit from the Delta and Omicron variants on self-assembled monolayers by Quartz Crystal Microbalance. The results clearly show a significant difference in adsorption capacity between the different variants, as well as between the S1 and S2 subunits. Overall, our study demonstrates that while the Omicron variant is able to adsorb much more successfully than the Delta, both variants show enhanced adsorption capacity than that of the original strain. We also examined the influence of pH conditions on the adsorption ability of the S1 subunit and found that adsorption was strongest at pH 7.4, which is the physiological pH. The main conclusion of this study is that there is a strong correlation between the adsorption capacity and the transmissibility of the various SARS-CoV-2 variants. |
| first_indexed | 2024-04-12T14:26:40Z |
| format | Article |
| id | doaj.art-b6fc4f8c79cc4c16a9fbf11aebbcd962 |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-04-12T14:26:40Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-b6fc4f8c79cc4c16a9fbf11aebbcd9622022-12-22T03:29:26ZengElsevierMaterials Today Bio2590-00642022-03-0114100265Adsorption of SARS CoV-2 spike proteins on various functionalized surfaces correlates with the high transmissibility of Delta and Omicron variantsDaniela Dobrynin0Iryna Polishchuk1Lotan Portal2Ivan Zlotver3Alejandro Sosnik4Boaz Pokroy5Bio-Inspired Surface Engineering and Biomineralization Lab, Department of Materials Science and Engineering, Technion – Israel Institute of Technology, 32000, Haifa, IsraelBio-Inspired Surface Engineering and Biomineralization Lab, Department of Materials Science and Engineering, Technion – Israel Institute of Technology, 32000, Haifa, IsraelBio-Inspired Surface Engineering and Biomineralization Lab, Department of Materials Science and Engineering, Technion – Israel Institute of Technology, 32000, Haifa, IsraelLaboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion – Israel Institute of Technology, 32000, Haifa, IsraelLaboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion – Israel Institute of Technology, 32000, Haifa, Israel; Corresponding author.Bio-Inspired Surface Engineering and Biomineralization Lab, Department of Materials Science and Engineering, Technion – Israel Institute of Technology, 32000, Haifa, Israel; Corresponding author.The SARS-CoV-2 virus emerged at the end of 2019 and rapidly developed several mutated variants, specifically the Delta and Omicron, which demonstrate higher transmissibility and escalating infection cases worldwide. The dominant transmission pathway of this virus is via human-to-human contact and aerosols which once inhaled interact with the mucosal tissue, but another possible route is through contact with surfaces contaminated with SARS-CoV-2, often exhibiting long-term survival. Here we compare the adsorption capacities of the S1 and S2 subunits of the spike (S) protein from the original variant to that of the S1 subunit from the Delta and Omicron variants on self-assembled monolayers by Quartz Crystal Microbalance. The results clearly show a significant difference in adsorption capacity between the different variants, as well as between the S1 and S2 subunits. Overall, our study demonstrates that while the Omicron variant is able to adsorb much more successfully than the Delta, both variants show enhanced adsorption capacity than that of the original strain. We also examined the influence of pH conditions on the adsorption ability of the S1 subunit and found that adsorption was strongest at pH 7.4, which is the physiological pH. The main conclusion of this study is that there is a strong correlation between the adsorption capacity and the transmissibility of the various SARS-CoV-2 variants.http://www.sciencedirect.com/science/article/pii/S2590006422000631SARS-CoV-2Spike proteinCOVID-19Omicron variantDelta variantQuartz crystal microbalance |
| spellingShingle | Daniela Dobrynin Iryna Polishchuk Lotan Portal Ivan Zlotver Alejandro Sosnik Boaz Pokroy Adsorption of SARS CoV-2 spike proteins on various functionalized surfaces correlates with the high transmissibility of Delta and Omicron variants Materials Today Bio SARS-CoV-2 Spike protein COVID-19 Omicron variant Delta variant Quartz crystal microbalance |
| title | Adsorption of SARS CoV-2 spike proteins on various functionalized surfaces correlates with the high transmissibility of Delta and Omicron variants |
| title_full | Adsorption of SARS CoV-2 spike proteins on various functionalized surfaces correlates with the high transmissibility of Delta and Omicron variants |
| title_fullStr | Adsorption of SARS CoV-2 spike proteins on various functionalized surfaces correlates with the high transmissibility of Delta and Omicron variants |
| title_full_unstemmed | Adsorption of SARS CoV-2 spike proteins on various functionalized surfaces correlates with the high transmissibility of Delta and Omicron variants |
| title_short | Adsorption of SARS CoV-2 spike proteins on various functionalized surfaces correlates with the high transmissibility of Delta and Omicron variants |
| title_sort | adsorption of sars cov 2 spike proteins on various functionalized surfaces correlates with the high transmissibility of delta and omicron variants |
| topic | SARS-CoV-2 Spike protein COVID-19 Omicron variant Delta variant Quartz crystal microbalance |
| url | http://www.sciencedirect.com/science/article/pii/S2590006422000631 |
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