SARS-CoV-2 and Skin: The Pathologist’s Point of View
The SARS-CoV-2 pandemic has dramatically changed our lives and habits. In just a few months, the most advanced and efficient health systems in the world have been overwhelmed by an infectious disease that has caused 3.26 million deaths and more than 156 million cases worldwide. Although the lung is...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/6/838 |
| _version_ | 1797531332331438080 |
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| author | Gerardo Cazzato Giulia Mazzia Antonietta Cimmino Anna Colagrande Sara Sablone Teresa Lettini Roberta Rossi Nadia Santarella Rossella Elia Eleonora Nacchiero Michele Maruccia Andrea Marzullo Eugenio Maiorano Giuseppe Giudice Giuseppe Ingravallo Leonardo Resta |
| author_facet | Gerardo Cazzato Giulia Mazzia Antonietta Cimmino Anna Colagrande Sara Sablone Teresa Lettini Roberta Rossi Nadia Santarella Rossella Elia Eleonora Nacchiero Michele Maruccia Andrea Marzullo Eugenio Maiorano Giuseppe Giudice Giuseppe Ingravallo Leonardo Resta |
| author_sort | Gerardo Cazzato |
| collection | DOAJ |
| description | The SARS-CoV-2 pandemic has dramatically changed our lives and habits. In just a few months, the most advanced and efficient health systems in the world have been overwhelmed by an infectious disease that has caused 3.26 million deaths and more than 156 million cases worldwide. Although the lung is the most frequently affected organ, the skin has also resulted in being a target body district, so much so as to suggest it may be a real “sentinel” of COVID-19 disease. Here we present 17 cases of skin manifestations studied and analyzed in recent months in our Department; immunohistochemical investigations were carried out on samples for the S1 spike-protein of SARS-CoV-2, as well as electron microscopy investigations showing evidence of virions within the constituent cells of the eccrine sweat glands and the endothelium of small blood vessels. Finally, we conduct a brief review of the COVID-related skin manifestations, confirmed by immunohistochemistry and/or electron microscopy, described in the literature. |
| first_indexed | 2024-03-10T10:42:16Z |
| format | Article |
| id | doaj.art-b6fd7f90d5f64bb7b6413daf28390916 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T10:42:16Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-b6fd7f90d5f64bb7b6413daf283909162023-11-21T22:53:51ZengMDPI AGBiomolecules2218-273X2021-06-0111683810.3390/biom11060838SARS-CoV-2 and Skin: The Pathologist’s Point of ViewGerardo Cazzato0Giulia Mazzia1Antonietta Cimmino2Anna Colagrande3Sara Sablone4Teresa Lettini5Roberta Rossi6Nadia Santarella7Rossella Elia8Eleonora Nacchiero9Michele Maruccia10Andrea Marzullo11Eugenio Maiorano12Giuseppe Giudice13Giuseppe Ingravallo14Leonardo Resta15Department of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, Section of Legal Medicine, Policlinico di Bari Hospital, University of Bari, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation, Section of Plastic and Reconstructive Surgery, University of Bari, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation, Section of Plastic and Reconstructive Surgery, University of Bari, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation, Section of Plastic and Reconstructive Surgery, University of Bari, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, Section of Legal Medicine, Policlinico di Bari Hospital, University of Bari, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari “Aldo Moro”, 70124 Bari, ItalyThe SARS-CoV-2 pandemic has dramatically changed our lives and habits. In just a few months, the most advanced and efficient health systems in the world have been overwhelmed by an infectious disease that has caused 3.26 million deaths and more than 156 million cases worldwide. Although the lung is the most frequently affected organ, the skin has also resulted in being a target body district, so much so as to suggest it may be a real “sentinel” of COVID-19 disease. Here we present 17 cases of skin manifestations studied and analyzed in recent months in our Department; immunohistochemical investigations were carried out on samples for the S1 spike-protein of SARS-CoV-2, as well as electron microscopy investigations showing evidence of virions within the constituent cells of the eccrine sweat glands and the endothelium of small blood vessels. Finally, we conduct a brief review of the COVID-related skin manifestations, confirmed by immunohistochemistry and/or electron microscopy, described in the literature.https://www.mdpi.com/2218-273X/11/6/838SARS-CoV-2COVID-19skineruption |
| spellingShingle | Gerardo Cazzato Giulia Mazzia Antonietta Cimmino Anna Colagrande Sara Sablone Teresa Lettini Roberta Rossi Nadia Santarella Rossella Elia Eleonora Nacchiero Michele Maruccia Andrea Marzullo Eugenio Maiorano Giuseppe Giudice Giuseppe Ingravallo Leonardo Resta SARS-CoV-2 and Skin: The Pathologist’s Point of View Biomolecules SARS-CoV-2 COVID-19 skin eruption |
| title | SARS-CoV-2 and Skin: The Pathologist’s Point of View |
| title_full | SARS-CoV-2 and Skin: The Pathologist’s Point of View |
| title_fullStr | SARS-CoV-2 and Skin: The Pathologist’s Point of View |
| title_full_unstemmed | SARS-CoV-2 and Skin: The Pathologist’s Point of View |
| title_short | SARS-CoV-2 and Skin: The Pathologist’s Point of View |
| title_sort | sars cov 2 and skin the pathologist s point of view |
| topic | SARS-CoV-2 COVID-19 skin eruption |
| url | https://www.mdpi.com/2218-273X/11/6/838 |
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