Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation
Streptococcal siglec-like binding regions (SLBRs) selectively bind cell surface glycans, but the basis for this selectivity is not understood. Here, the authors identify selectivity-modulating SLBR regions and study how changes in SLBR glycan selectivity affect interactions with human glycoprotein r...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30509-y |
| _version_ | 1818554766667546624 |
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| author | Barbara A. Bensing Haley E. Stubbs Rupesh Agarwal Izumi Yamakawa Kelvin Luong Kemal Solakyildirim Hai Yu Azadeh Hadadianpour Manuel A. Castro Kevin P. Fialkowski KeAndreya M. Morrison Zdzislaw Wawrzak Xi Chen Carlito B. Lebrilla Jerome Baudry Jeremy C. Smith Paul M. Sullam T. M. Iverson |
| author_facet | Barbara A. Bensing Haley E. Stubbs Rupesh Agarwal Izumi Yamakawa Kelvin Luong Kemal Solakyildirim Hai Yu Azadeh Hadadianpour Manuel A. Castro Kevin P. Fialkowski KeAndreya M. Morrison Zdzislaw Wawrzak Xi Chen Carlito B. Lebrilla Jerome Baudry Jeremy C. Smith Paul M. Sullam T. M. Iverson |
| author_sort | Barbara A. Bensing |
| collection | DOAJ |
| description | Streptococcal siglec-like binding regions (SLBRs) selectively bind cell surface glycans, but the basis for this selectivity is not understood. Here, the authors identify selectivity-modulating SLBR regions and study how changes in SLBR glycan selectivity affect interactions with human glycoprotein receptors. |
| first_indexed | 2024-12-12T09:44:25Z |
| format | Article |
| id | doaj.art-b700213795704bd98ce0a30827b2135e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-12T09:44:25Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b700213795704bd98ce0a30827b2135e2022-12-22T00:28:27ZengNature PortfolioNature Communications2041-17232022-05-0113111410.1038/s41467-022-30509-yOrigins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptationBarbara A. Bensing0Haley E. Stubbs1Rupesh Agarwal2Izumi Yamakawa3Kelvin Luong4Kemal Solakyildirim5Hai Yu6Azadeh Hadadianpour7Manuel A. Castro8Kevin P. Fialkowski9KeAndreya M. Morrison10Zdzislaw Wawrzak11Xi Chen12Carlito B. Lebrilla13Jerome Baudry14Jeremy C. Smith15Paul M. Sullam16T. M. Iverson17Division of Infectious Diseases, Veterans Affairs Medical Center, Department of Medicine, University of CaliforniaGraduate Program in Chemical and Physical Biology, Vanderbilt UniversityUniversity of Tennessee/Oak Ridge National Laboratory, Center for Molecular Biophysics, Biosciences Division, Oak Ridge National LaboratoryDepartment of Pharmacology, Vanderbilt UniversityDepartment of Pharmacology, Vanderbilt UniversityDepartment of Chemistry, Erzincan Binali Yildirim UniversityDepartment of Chemistry, University of CaliforniaDepartment of Microbiology, Pathology, and Immunology, Vanderbilt UniversityDepartment of Biochemistry, Vanderbilt UniversityDepartment of Pharmacology, Vanderbilt UniversityDepartment of Pharmacology, School of Graduate Studies and Research, Meharry Medical CollegeLS-CAT Synchrotron Research Center, Northwestern UniversityDepartment of Chemistry, University of CaliforniaDepartment of Chemistry, University of CaliforniaDepartment of Biological Sciences, The University of Alabama in HuntsvilleUniversity of Tennessee/Oak Ridge National Laboratory, Center for Molecular Biophysics, Biosciences Division, Oak Ridge National LaboratoryDivision of Infectious Diseases, Veterans Affairs Medical Center, Department of Medicine, University of CaliforniaDepartment of Pharmacology, Vanderbilt UniversityStreptococcal siglec-like binding regions (SLBRs) selectively bind cell surface glycans, but the basis for this selectivity is not understood. Here, the authors identify selectivity-modulating SLBR regions and study how changes in SLBR glycan selectivity affect interactions with human glycoprotein receptors.https://doi.org/10.1038/s41467-022-30509-y |
| spellingShingle | Barbara A. Bensing Haley E. Stubbs Rupesh Agarwal Izumi Yamakawa Kelvin Luong Kemal Solakyildirim Hai Yu Azadeh Hadadianpour Manuel A. Castro Kevin P. Fialkowski KeAndreya M. Morrison Zdzislaw Wawrzak Xi Chen Carlito B. Lebrilla Jerome Baudry Jeremy C. Smith Paul M. Sullam T. M. Iverson Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation Nature Communications |
| title | Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation |
| title_full | Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation |
| title_fullStr | Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation |
| title_full_unstemmed | Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation |
| title_short | Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation |
| title_sort | origins of glycan selectivity in streptococcal siglec like adhesins suggest mechanisms of receptor adaptation |
| url | https://doi.org/10.1038/s41467-022-30509-y |
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