Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation

Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation

Streptococcal siglec-like binding regions (SLBRs) selectively bind cell surface glycans, but the basis for this selectivity is not understood. Here, the authors identify selectivity-modulating SLBR regions and study how changes in SLBR glycan selectivity affect interactions with human glycoprotein r...

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Bibliographic Details
Main Authors: Barbara A. Bensing, Haley E. Stubbs, Rupesh Agarwal, Izumi Yamakawa, Kelvin Luong, Kemal Solakyildirim, Hai Yu, Azadeh Hadadianpour, Manuel A. Castro, Kevin P. Fialkowski, KeAndreya M. Morrison, Zdzislaw Wawrzak, Xi Chen, Carlito B. Lebrilla, Jerome Baudry, Jeremy C. Smith, Paul M. Sullam, T. M. Iverson
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30509-y

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