Functionality and Neurocognition in Patients With Bipolar Disorder After a Physical-Exercise Program (FINEXT-BD Study): Protocol of a Randomized Interventionist Program
Introduction: Recent studies have shown that symptoms of psychiatric illness, functionality, and cognitive function improve with exercise. The aim of this study will be to investigate whether the implementation of an individualized exercise program will improve the functional status of patients with...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2020.568455/full |
| _version_ | 1811296096873349120 |
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| author | Saínza García Saínza García Saínza García Saínza García Ilargi Gorostegi-Anduaga Ilargi Gorostegi-Anduaga Edurne García-Corres Edurne García-Corres Edurne García-Corres Sara Maldonado-Martín Sara Maldonado-Martín Karina S. MacDowell Karina S. MacDowell Cristina Bermúdez-Ampudia María J. Apodaca Irene Pérez-Landaluce Ignacio Tobalina-Larrea Ignacio Tobalina-Larrea Juan C. Leza Juan C. Leza A. González-Pinto A. González-Pinto A. González-Pinto A. González-Pinto |
| author_facet | Saínza García Saínza García Saínza García Saínza García Ilargi Gorostegi-Anduaga Ilargi Gorostegi-Anduaga Edurne García-Corres Edurne García-Corres Edurne García-Corres Sara Maldonado-Martín Sara Maldonado-Martín Karina S. MacDowell Karina S. MacDowell Cristina Bermúdez-Ampudia María J. Apodaca Irene Pérez-Landaluce Ignacio Tobalina-Larrea Ignacio Tobalina-Larrea Juan C. Leza Juan C. Leza A. González-Pinto A. González-Pinto A. González-Pinto A. González-Pinto |
| author_sort | Saínza García |
| collection | DOAJ |
| description | Introduction: Recent studies have shown that symptoms of psychiatric illness, functionality, and cognitive function improve with exercise. The aim of this study will be to investigate whether the implementation of an individualized exercise program will improve the functional status of patients with bipolar disorder (BD).Methods: This longitudinal, interventional, randomized, controlled, simple-blind clinical trial will include 80 patients aged 18–65 years, all of them with BD diagnosis. Patients will be randomly assigned to a physical exercise intervention + Treatment-As-Usual (TAU) group and a non-intervention + TAU group. Patients will be assessed by an extensive battery of clinical tests, physical parameters (e.g., brain structure changes measured by optical coherence tomography, cardiorespiratory fitness) and biological parameters (inflammation, oxidative stress and neurotrophic factors) at baseline, after a 4-month intervention period, and 6-month follow-up.Discussion: This is an innovative study aimed at gaining a deeper understanding of the physiopathology of BD and determining whether the prognosis and evolution of the disease can be improved through modifiable areas of the patient's lifestyle.Clinical Trial Registration: NCT04400630. NCT clinicaltrials.gov. Date of registration in primary registry 22 May 2020. clinicaltrials.gov. |
| first_indexed | 2024-04-13T05:43:17Z |
| format | Article |
| id | doaj.art-b700a4e4769142f7a875ba4399808036 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-13T05:43:17Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-b700a4e4769142f7a875ba43998080362022-12-22T03:00:01ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-10-011110.3389/fpsyt.2020.568455568455Functionality and Neurocognition in Patients With Bipolar Disorder After a Physical-Exercise Program (FINEXT-BD Study): Protocol of a Randomized Interventionist ProgramSaínza García0Saínza García1Saínza García2Saínza García3Ilargi Gorostegi-Anduaga4Ilargi Gorostegi-Anduaga5Edurne García-Corres6Edurne García-Corres7Edurne García-Corres8Sara Maldonado-Martín9Sara Maldonado-Martín10Karina S. MacDowell11Karina S. MacDowell12Cristina Bermúdez-Ampudia13María J. Apodaca14Irene Pérez-Landaluce15Ignacio Tobalina-Larrea16Ignacio Tobalina-Larrea17Juan C. Leza18Juan C. Leza19A. González-Pinto20A. González-Pinto21A. González-Pinto22A. González-Pinto23Severe Mental Illness Research Group, Bioaraba Health Research Institute, Vitoria-Gasteiz, SpainDepartment of Psychiatry, Osakdietza Basque Health Service, Araba University Hospital, Vitoria-Gasteiz, SpainCentre for Biomedical Research Network on Mental Health (CIBERSAM), Madrid, SpainSchool of Medicine, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, SpainDepartment of Physical Education and Sport, Faculty of Education and Sport, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, SpainGIzartea, Kirola eta Ariketa Fisikoa Ikerkuntza Taldea (GIKAFIT), Society, Sports, and Physical Exercise Research Group, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, SpainSevere Mental Illness Research Group, Bioaraba Health Research Institute, Vitoria-Gasteiz, SpainDepartment of Psychiatry, Osakdietza Basque Health Service, Araba University Hospital, Vitoria-Gasteiz, SpainSchool of Medicine, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, SpainDepartment of Physical Education and Sport, Faculty of Education and Sport, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, SpainGIzartea, Kirola eta Ariketa Fisikoa Ikerkuntza Taldea (GIKAFIT), Society, Sports, and Physical Exercise Research Group, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, SpainCentre for Biomedical Research Network on Mental Health (CIBERSAM), Madrid, SpainDepartment of Pharmacology and Toxicology, Faculty of Medicine, Complutense University of Madrid, Madrid, SpainEpidemiology and Public Health Research Group, Bioaraba Health Research Institute, Vitoria-Gasteiz, SpainDepartment of Cardiology, Osakdietza Basque Health Service, Araba University Hospital, Vitoria-Gasteiz, Spain0Department of Ophthalmology, Osakdietza Basque Health Service, Araba University Hospital, Vitoria-Gasteiz, SpainSchool of Medicine, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, Spain1Department of Nuclear Medicine, Osakdietza Basque Health Service, Araba University Hospital, Vitoria-Gasteiz, SpainCentre for Biomedical Research Network on Mental Health (CIBERSAM), Madrid, SpainDepartment of Pharmacology and Toxicology, Faculty of Medicine, Complutense University of Madrid, Madrid, SpainSevere Mental Illness Research Group, Bioaraba Health Research Institute, Vitoria-Gasteiz, SpainDepartment of Psychiatry, Osakdietza Basque Health Service, Araba University Hospital, Vitoria-Gasteiz, SpainCentre for Biomedical Research Network on Mental Health (CIBERSAM), Madrid, SpainSchool of Medicine, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, SpainIntroduction: Recent studies have shown that symptoms of psychiatric illness, functionality, and cognitive function improve with exercise. The aim of this study will be to investigate whether the implementation of an individualized exercise program will improve the functional status of patients with bipolar disorder (BD).Methods: This longitudinal, interventional, randomized, controlled, simple-blind clinical trial will include 80 patients aged 18–65 years, all of them with BD diagnosis. Patients will be randomly assigned to a physical exercise intervention + Treatment-As-Usual (TAU) group and a non-intervention + TAU group. Patients will be assessed by an extensive battery of clinical tests, physical parameters (e.g., brain structure changes measured by optical coherence tomography, cardiorespiratory fitness) and biological parameters (inflammation, oxidative stress and neurotrophic factors) at baseline, after a 4-month intervention period, and 6-month follow-up.Discussion: This is an innovative study aimed at gaining a deeper understanding of the physiopathology of BD and determining whether the prognosis and evolution of the disease can be improved through modifiable areas of the patient's lifestyle.Clinical Trial Registration: NCT04400630. NCT clinicaltrials.gov. Date of registration in primary registry 22 May 2020. clinicaltrials.gov.https://www.frontiersin.org/articles/10.3389/fpsyt.2020.568455/fullbipolar disorderphysical exerciseintervention programneurocognitionfunctional capacity |
| spellingShingle | Saínza García Saínza García Saínza García Saínza García Ilargi Gorostegi-Anduaga Ilargi Gorostegi-Anduaga Edurne García-Corres Edurne García-Corres Edurne García-Corres Sara Maldonado-Martín Sara Maldonado-Martín Karina S. MacDowell Karina S. MacDowell Cristina Bermúdez-Ampudia María J. Apodaca Irene Pérez-Landaluce Ignacio Tobalina-Larrea Ignacio Tobalina-Larrea Juan C. Leza Juan C. Leza A. González-Pinto A. González-Pinto A. González-Pinto A. González-Pinto Functionality and Neurocognition in Patients With Bipolar Disorder After a Physical-Exercise Program (FINEXT-BD Study): Protocol of a Randomized Interventionist Program Frontiers in Psychiatry bipolar disorder physical exercise intervention program neurocognition functional capacity |
| title | Functionality and Neurocognition in Patients With Bipolar Disorder After a Physical-Exercise Program (FINEXT-BD Study): Protocol of a Randomized Interventionist Program |
| title_full | Functionality and Neurocognition in Patients With Bipolar Disorder After a Physical-Exercise Program (FINEXT-BD Study): Protocol of a Randomized Interventionist Program |
| title_fullStr | Functionality and Neurocognition in Patients With Bipolar Disorder After a Physical-Exercise Program (FINEXT-BD Study): Protocol of a Randomized Interventionist Program |
| title_full_unstemmed | Functionality and Neurocognition in Patients With Bipolar Disorder After a Physical-Exercise Program (FINEXT-BD Study): Protocol of a Randomized Interventionist Program |
| title_short | Functionality and Neurocognition in Patients With Bipolar Disorder After a Physical-Exercise Program (FINEXT-BD Study): Protocol of a Randomized Interventionist Program |
| title_sort | functionality and neurocognition in patients with bipolar disorder after a physical exercise program finext bd study protocol of a randomized interventionist program |
| topic | bipolar disorder physical exercise intervention program neurocognition functional capacity |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2020.568455/full |
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