Can we abandon foregut exclusion for an ideal and safe metabolic surgery?
Foregut (foregut exclusions) and hindgut (rapid transit of nutrients to the distal intestine) theories are the most commonly used explanations for the metabolic improvements observed after metabolic surgeries. However, several procedures that do not comprise duodenal exclusions, such as sleeve with...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1014901/full |
| _version_ | 1811232621929168896 |
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| author | Jason Widjaja Yuxiao Chu Jianjun Yang Jian Wang Yan Gu |
| author_facet | Jason Widjaja Yuxiao Chu Jianjun Yang Jian Wang Yan Gu |
| author_sort | Jason Widjaja |
| collection | DOAJ |
| description | Foregut (foregut exclusions) and hindgut (rapid transit of nutrients to the distal intestine) theories are the most commonly used explanations for the metabolic improvements observed after metabolic surgeries. However, several procedures that do not comprise duodenal exclusions, such as sleeve with jejunojejunal bypass, ileal interposition, and transit bipartition and sleeve gastrectomy were found to have similar diabetes remission rates when compared with duodenal exclusion procedures, such as gastric bypass, biliopancreatic diversion with duodenal switch, and diverted sleeve with ileal interposition. Moreover, the complete exclusion of the proximal intestine could result in the malabsorption of several important micronutrients. This article reviews commonly performed procedures, with and without foregut exclusion, to better comprehend whether there is a critical need to include foregut exclusion in metabolic surgery. |
| first_indexed | 2024-04-12T11:05:58Z |
| format | Article |
| id | doaj.art-b702e47f45b04048aadb44760bb0b85f |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T11:05:58Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-b702e47f45b04048aadb44760bb0b85f2022-12-22T03:35:45ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-11-011310.3389/fendo.2022.10149011014901Can we abandon foregut exclusion for an ideal and safe metabolic surgery?Jason Widjaja0Yuxiao Chu1Jianjun Yang2Jian Wang3Yan Gu4Department of General Surgery, Fudan University Affiliated Huadong Hospital, Shanghai, ChinaDepartment of Gastrointestinal Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of General Surgery, Fudan University Affiliated Huadong Hospital, Shanghai, ChinaDepartment of Gastrointestinal Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of General Surgery, Fudan University Affiliated Huadong Hospital, Shanghai, ChinaForegut (foregut exclusions) and hindgut (rapid transit of nutrients to the distal intestine) theories are the most commonly used explanations for the metabolic improvements observed after metabolic surgeries. However, several procedures that do not comprise duodenal exclusions, such as sleeve with jejunojejunal bypass, ileal interposition, and transit bipartition and sleeve gastrectomy were found to have similar diabetes remission rates when compared with duodenal exclusion procedures, such as gastric bypass, biliopancreatic diversion with duodenal switch, and diverted sleeve with ileal interposition. Moreover, the complete exclusion of the proximal intestine could result in the malabsorption of several important micronutrients. This article reviews commonly performed procedures, with and without foregut exclusion, to better comprehend whether there is a critical need to include foregut exclusion in metabolic surgery.https://www.frontiersin.org/articles/10.3389/fendo.2022.1014901/fullforegut hypothesismicronutrienttype-2 diabetesbariatric surgerymetabolic surgery |
| spellingShingle | Jason Widjaja Yuxiao Chu Jianjun Yang Jian Wang Yan Gu Can we abandon foregut exclusion for an ideal and safe metabolic surgery? Frontiers in Endocrinology foregut hypothesis micronutrient type-2 diabetes bariatric surgery metabolic surgery |
| title | Can we abandon foregut exclusion for an ideal and safe metabolic surgery? |
| title_full | Can we abandon foregut exclusion for an ideal and safe metabolic surgery? |
| title_fullStr | Can we abandon foregut exclusion for an ideal and safe metabolic surgery? |
| title_full_unstemmed | Can we abandon foregut exclusion for an ideal and safe metabolic surgery? |
| title_short | Can we abandon foregut exclusion for an ideal and safe metabolic surgery? |
| title_sort | can we abandon foregut exclusion for an ideal and safe metabolic surgery |
| topic | foregut hypothesis micronutrient type-2 diabetes bariatric surgery metabolic surgery |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1014901/full |
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