PARP1 inhibition elicits immune responses against non-small cell lung cancer

PARP1 inhibition elicits immune responses against non-small cell lung cancer

High levels of intracellular poly(ADP-ribose) (PAR) resulting from an elevated activity of PAR polymerase-1 (PARP1) correlate with poor infiltration of non-small cell lung cancers by cytotoxic T lymphocytes and dismal patient prognosis. Preclinical experimentation now demonstrates that PARP1 inhibit...

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Bibliographic Details
Main Authors: Pan Juncheng, Antoine Lafarge, Guido Kroemer, Maria Castedo
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:OncoImmunology
Subjects:
Anticancer immune response
metabolism
tumor microenvironment
immune escape
non-small cell lung cancer
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2111915
Description
Summary:High levels of intracellular poly(ADP-ribose) (PAR) resulting from an elevated activity of PAR polymerase-1 (PARP1) correlate with poor infiltration of non-small cell lung cancers by cytotoxic T lymphocytes and dismal patient prognosis. Preclinical experimentation now demonstrates that PARP1 inhibition in cancer cells mediates strong immunostimulatory effects.
ISSN:2162-402X

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