PARP1 inhibition elicits immune responses against non-small cell lung cancer
High levels of intracellular poly(ADP-ribose) (PAR) resulting from an elevated activity of PAR polymerase-1 (PARP1) correlate with poor infiltration of non-small cell lung cancers by cytotoxic T lymphocytes and dismal patient prognosis. Preclinical experimentation now demonstrates that PARP1 inhibit...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | OncoImmunology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/2162402X.2022.2111915 |
| _version_ | 1828301538555068416 |
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| author | Pan Juncheng Antoine Lafarge Guido Kroemer Maria Castedo |
| author_facet | Pan Juncheng Antoine Lafarge Guido Kroemer Maria Castedo |
| author_sort | Pan Juncheng |
| collection | DOAJ |
| description | High levels of intracellular poly(ADP-ribose) (PAR) resulting from an elevated activity of PAR polymerase-1 (PARP1) correlate with poor infiltration of non-small cell lung cancers by cytotoxic T lymphocytes and dismal patient prognosis. Preclinical experimentation now demonstrates that PARP1 inhibition in cancer cells mediates strong immunostimulatory effects. |
| first_indexed | 2024-04-13T13:24:11Z |
| format | Article |
| id | doaj.art-b704406c20af44d5a7a427f605b20c4a |
| institution | Directory Open Access Journal |
| issn | 2162-402X |
| language | English |
| last_indexed | 2024-04-13T13:24:11Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj.art-b704406c20af44d5a7a427f605b20c4a2022-12-22T02:45:13ZengTaylor & Francis GroupOncoImmunology2162-402X2022-12-0111110.1080/2162402X.2022.2111915PARP1 inhibition elicits immune responses against non-small cell lung cancerPan Juncheng0Antoine Lafarge1Guido Kroemer2Maria Castedo3Equipe 11 Labellisée Par la Ligue Contre le Cancer, Université de Paris Cité, Sorbonne Université, Paris, FranceEquipe 11 Labellisée Par la Ligue Contre le Cancer, Université de Paris Cité, Sorbonne Université, Paris, FranceEquipe 11 Labellisée Par la Ligue Contre le Cancer, Université de Paris Cité, Sorbonne Université, Paris, FranceEquipe 11 Labellisée Par la Ligue Contre le Cancer, Université de Paris Cité, Sorbonne Université, Paris, FranceHigh levels of intracellular poly(ADP-ribose) (PAR) resulting from an elevated activity of PAR polymerase-1 (PARP1) correlate with poor infiltration of non-small cell lung cancers by cytotoxic T lymphocytes and dismal patient prognosis. Preclinical experimentation now demonstrates that PARP1 inhibition in cancer cells mediates strong immunostimulatory effects.https://www.tandfonline.com/doi/10.1080/2162402X.2022.2111915Anticancer immune responsemetabolismtumor microenvironmentimmune escapenon-small cell lung cancer |
| spellingShingle | Pan Juncheng Antoine Lafarge Guido Kroemer Maria Castedo PARP1 inhibition elicits immune responses against non-small cell lung cancer OncoImmunology Anticancer immune response metabolism tumor microenvironment immune escape non-small cell lung cancer |
| title | PARP1 inhibition elicits immune responses against non-small cell lung cancer |
| title_full | PARP1 inhibition elicits immune responses against non-small cell lung cancer |
| title_fullStr | PARP1 inhibition elicits immune responses against non-small cell lung cancer |
| title_full_unstemmed | PARP1 inhibition elicits immune responses against non-small cell lung cancer |
| title_short | PARP1 inhibition elicits immune responses against non-small cell lung cancer |
| title_sort | parp1 inhibition elicits immune responses against non small cell lung cancer |
| topic | Anticancer immune response metabolism tumor microenvironment immune escape non-small cell lung cancer |
| url | https://www.tandfonline.com/doi/10.1080/2162402X.2022.2111915 |
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