Scaffolding of Mitogen-Activated Protein Kinase Signaling by β-Arrestins
β-arrestins were initially identified to desensitize and internalize G-protein-coupled receptors (GPCRs). Receptor-bound β-arrestins also initiate a second wave of signaling by scaffolding mitogen-activated protein kinase (MAPK) signaling components, MAPK kinase kinase, MAPK kinase, and MAPK. In par...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/2/1000 |
| _version_ | 1797493186566815744 |
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| author | Kiae Kim Yeonjin Han Longhan Duan Ka Young Chung |
| author_facet | Kiae Kim Yeonjin Han Longhan Duan Ka Young Chung |
| author_sort | Kiae Kim |
| collection | DOAJ |
| description | β-arrestins were initially identified to desensitize and internalize G-protein-coupled receptors (GPCRs). Receptor-bound β-arrestins also initiate a second wave of signaling by scaffolding mitogen-activated protein kinase (MAPK) signaling components, MAPK kinase kinase, MAPK kinase, and MAPK. In particular, β-arrestins facilitate ERK1/2 or JNK3 activation by scaffolding signal cascade components such as ERK1/2-MEK1-cRaf or JNK3-MKK4/7-ASK1. Understanding the precise molecular and structural mechanisms of β-arrestin-mediated MAPK scaffolding assembly would deepen our understanding of GPCR-mediated MAPK activation and provide clues for the selective regulation of the MAPK signaling cascade for therapeutic purposes. Over the last decade, numerous research groups have attempted to understand the molecular and structural mechanisms of β-arrestin-mediated MAPK scaffolding assembly. Although not providing the complete mechanism, these efforts suggest potential binding interfaces between β-arrestins and MAPK signaling components and the mechanism for MAPK signal amplification by β-arrestin-mediated scaffolding. This review summarizes recent developments of cellular and molecular works on the scaffolding mechanism of β-arrestin for MAPK signaling cascade. |
| first_indexed | 2024-03-10T01:16:24Z |
| format | Article |
| id | doaj.art-b705057e242747cdaf97f4836486656a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:16:24Z |
| publishDate | 2022-01-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b705057e242747cdaf97f4836486656a2023-11-23T14:08:00ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-01-01232100010.3390/ijms23021000Scaffolding of Mitogen-Activated Protein Kinase Signaling by β-ArrestinsKiae Kim0Yeonjin Han1Longhan Duan2Ka Young Chung3School of Pharmacy, Sungkyunkwan University, 2066 Seoburo, Suwon 16419, KoreaSchool of Pharmacy, Sungkyunkwan University, 2066 Seoburo, Suwon 16419, KoreaSchool of Pharmacy, Sungkyunkwan University, 2066 Seoburo, Suwon 16419, KoreaSchool of Pharmacy, Sungkyunkwan University, 2066 Seoburo, Suwon 16419, Koreaβ-arrestins were initially identified to desensitize and internalize G-protein-coupled receptors (GPCRs). Receptor-bound β-arrestins also initiate a second wave of signaling by scaffolding mitogen-activated protein kinase (MAPK) signaling components, MAPK kinase kinase, MAPK kinase, and MAPK. In particular, β-arrestins facilitate ERK1/2 or JNK3 activation by scaffolding signal cascade components such as ERK1/2-MEK1-cRaf or JNK3-MKK4/7-ASK1. Understanding the precise molecular and structural mechanisms of β-arrestin-mediated MAPK scaffolding assembly would deepen our understanding of GPCR-mediated MAPK activation and provide clues for the selective regulation of the MAPK signaling cascade for therapeutic purposes. Over the last decade, numerous research groups have attempted to understand the molecular and structural mechanisms of β-arrestin-mediated MAPK scaffolding assembly. Although not providing the complete mechanism, these efforts suggest potential binding interfaces between β-arrestins and MAPK signaling components and the mechanism for MAPK signal amplification by β-arrestin-mediated scaffolding. This review summarizes recent developments of cellular and molecular works on the scaffolding mechanism of β-arrestin for MAPK signaling cascade.https://www.mdpi.com/1422-0067/23/2/1000arrestinMAPKscaffoldprotein structure |
| spellingShingle | Kiae Kim Yeonjin Han Longhan Duan Ka Young Chung Scaffolding of Mitogen-Activated Protein Kinase Signaling by β-Arrestins International Journal of Molecular Sciences arrestin MAPK scaffold protein structure |
| title | Scaffolding of Mitogen-Activated Protein Kinase Signaling by β-Arrestins |
| title_full | Scaffolding of Mitogen-Activated Protein Kinase Signaling by β-Arrestins |
| title_fullStr | Scaffolding of Mitogen-Activated Protein Kinase Signaling by β-Arrestins |
| title_full_unstemmed | Scaffolding of Mitogen-Activated Protein Kinase Signaling by β-Arrestins |
| title_short | Scaffolding of Mitogen-Activated Protein Kinase Signaling by β-Arrestins |
| title_sort | scaffolding of mitogen activated protein kinase signaling by β arrestins |
| topic | arrestin MAPK scaffold protein structure |
| url | https://www.mdpi.com/1422-0067/23/2/1000 |
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