In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes
In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)-mediated calcium (Ca2+) release plays a centr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.629522/full |
| _version_ | 1818668238908686336 |
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| author | Ulises Ahumada-Castro Galdo Bustos Eduardo Silva-Pavez Andrea Puebla-Huerta Alenka Lovy Alenka Lovy César Cárdenas César Cárdenas César Cárdenas |
| author_facet | Ulises Ahumada-Castro Galdo Bustos Eduardo Silva-Pavez Andrea Puebla-Huerta Alenka Lovy Alenka Lovy César Cárdenas César Cárdenas César Cárdenas |
| author_sort | Ulises Ahumada-Castro |
| collection | DOAJ |
| description | In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)-mediated calcium (Ca2+) release plays a central role. Recent evidence suggests that IP3R isoforms participate in synthesis and degradation pathways. This minireview will summarize the current findings in this area, emphasizing the critical role of Ca2+ communication on organelle function as well as catabolism and anabolism, particularly in cancer. |
| first_indexed | 2024-12-17T06:33:09Z |
| format | Article |
| id | doaj.art-b70527f940a24b41b11e74605904d11d |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-17T06:33:09Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-b70527f940a24b41b11e74605904d11d2022-12-21T22:00:05ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-03-01910.3389/fcell.2021.629522629522In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ FluxesUlises Ahumada-Castro0Galdo Bustos1Eduardo Silva-Pavez2Andrea Puebla-Huerta3Alenka Lovy4Alenka Lovy5César Cárdenas6César Cárdenas7César Cárdenas8Geroscience Center for Brain Health and Metabolism, Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago, ChileGeroscience Center for Brain Health and Metabolism, Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago, ChileGeroscience Center for Brain Health and Metabolism, Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago, ChileGeroscience Center for Brain Health and Metabolism, Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago, ChileGeroscience Center for Brain Health and Metabolism, Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago, ChileDepartment of Neuroscience, Center for Neuroscience Research, Tufts University School of Medicine, Boston, MA, United StatesGeroscience Center for Brain Health and Metabolism, Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago, ChileBuck Institute for Research on Aging, Novato, CA, United StatesDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, United StatesIn the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)-mediated calcium (Ca2+) release plays a central role. Recent evidence suggests that IP3R isoforms participate in synthesis and degradation pathways. This minireview will summarize the current findings in this area, emphasizing the critical role of Ca2+ communication on organelle function as well as catabolism and anabolism, particularly in cancer.https://www.frontiersin.org/articles/10.3389/fcell.2021.629522/fullIP3Rscalciumendoplasmic reticulummitochondrialysosomemetabolism |
| spellingShingle | Ulises Ahumada-Castro Galdo Bustos Eduardo Silva-Pavez Andrea Puebla-Huerta Alenka Lovy Alenka Lovy César Cárdenas César Cárdenas César Cárdenas In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes Frontiers in Cell and Developmental Biology IP3Rs calcium endoplasmic reticulum mitochondria lysosome metabolism |
| title | In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes |
| title_full | In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes |
| title_fullStr | In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes |
| title_full_unstemmed | In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes |
| title_short | In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes |
| title_sort | in the right place at the right time regulation of cell metabolism by ip3r mediated inter organelle ca2 fluxes |
| topic | IP3Rs calcium endoplasmic reticulum mitochondria lysosome metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.629522/full |
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