Tissue Engineering of the Urethra: From Bench to Bedside
Tissue engineering (TE) is a promising approach for repair/substitution of damaged tissues and organs. Urethral strictures are common and serious health conditions that impair quality of life and may lead to serious organ damage. The search for ideal materials for urethral repair has led to interest...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/12/1917 |
| _version_ | 1797506539451318272 |
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| author | Dusan Pastorek Martina Culenova Maria Csobonyeiova Veronika Skuciova Lubos Danisovic Stanislav Ziaran |
| author_facet | Dusan Pastorek Martina Culenova Maria Csobonyeiova Veronika Skuciova Lubos Danisovic Stanislav Ziaran |
| author_sort | Dusan Pastorek |
| collection | DOAJ |
| description | Tissue engineering (TE) is a promising approach for repair/substitution of damaged tissues and organs. Urethral strictures are common and serious health conditions that impair quality of life and may lead to serious organ damage. The search for ideal materials for urethral repair has led to interest of scientists and surgeons in urethral TE. Over the last decades, a significant amount of preclinical studies and considerable progress have been observed. In contrast, urethral TE has made slow progress in clinical practice so far. To address this, we conducted a systematic review of the literature on clinical applications of TE constructs for urethral repair in the last three decades. In summary, the TE approach is promising and effective, but many issues remain that need to be addressed for broader adoption of TE in urethral repair. Better design of trials, better cooperation of research groups and centralization could lead to reduction of costs and slowly proceed to commercialization and routine use of TE products for urethral reconstruction. |
| first_indexed | 2024-03-10T04:33:59Z |
| format | Article |
| id | doaj.art-b7067cd8b8e74f1f90bd5ba4b2493335 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T04:33:59Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-b7067cd8b8e74f1f90bd5ba4b24933352023-11-23T03:57:34ZengMDPI AGBiomedicines2227-90592021-12-01912191710.3390/biomedicines9121917Tissue Engineering of the Urethra: From Bench to BedsideDusan Pastorek0Martina Culenova1Maria Csobonyeiova2Veronika Skuciova3Lubos Danisovic4Stanislav Ziaran5Department of Urology, University Hospital Bratislava, Pazitkova 4, 821 01 Bratislava, SlovakiaInstitute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Sasinkova 4, 811 08 Bratislava, SlovakiaInstitute of Histology and Embryology, Faculty of Medicine, Comenius University, Sasinkova 4, 811 08 Bratislava, SlovakiaDepartment of Histology and Embryology, Jessenius Faculty of Medicine in Martin, Comenius University, Mala Hora 4, 036 01 Martin, SlovakiaInstitute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Sasinkova 4, 811 08 Bratislava, SlovakiaNational Institute of Rheumatic Diseases, Nabrezie I. Krasku 4, 921 12 Piestany, SlovakiaTissue engineering (TE) is a promising approach for repair/substitution of damaged tissues and organs. Urethral strictures are common and serious health conditions that impair quality of life and may lead to serious organ damage. The search for ideal materials for urethral repair has led to interest of scientists and surgeons in urethral TE. Over the last decades, a significant amount of preclinical studies and considerable progress have been observed. In contrast, urethral TE has made slow progress in clinical practice so far. To address this, we conducted a systematic review of the literature on clinical applications of TE constructs for urethral repair in the last three decades. In summary, the TE approach is promising and effective, but many issues remain that need to be addressed for broader adoption of TE in urethral repair. Better design of trials, better cooperation of research groups and centralization could lead to reduction of costs and slowly proceed to commercialization and routine use of TE products for urethral reconstruction.https://www.mdpi.com/2227-9059/9/12/1917tissue engineeringurethraurethral strictureurethral reconstructionstem cellsscaffolds |
| spellingShingle | Dusan Pastorek Martina Culenova Maria Csobonyeiova Veronika Skuciova Lubos Danisovic Stanislav Ziaran Tissue Engineering of the Urethra: From Bench to Bedside Biomedicines tissue engineering urethra urethral stricture urethral reconstruction stem cells scaffolds |
| title | Tissue Engineering of the Urethra: From Bench to Bedside |
| title_full | Tissue Engineering of the Urethra: From Bench to Bedside |
| title_fullStr | Tissue Engineering of the Urethra: From Bench to Bedside |
| title_full_unstemmed | Tissue Engineering of the Urethra: From Bench to Bedside |
| title_short | Tissue Engineering of the Urethra: From Bench to Bedside |
| title_sort | tissue engineering of the urethra from bench to bedside |
| topic | tissue engineering urethra urethral stricture urethral reconstruction stem cells scaffolds |
| url | https://www.mdpi.com/2227-9059/9/12/1917 |
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