| Summary: | Background/Aim. Pregnancies complicated with antiphospholipd syndrome are
associated with the increased perinatal mortality and morbidity. The aim of
this study was to assess perinatal outcome in pregnancies with primary
antiphospholipd syndrome. Methods. This prospective study evaluated perinatal
outcome in 25 pregnant women with antiphospholipid syndrome. After
establishing vital pregnancy all the patients were treated with
low-molecularweight heparin and aspirin. The perinatal outcome was measured
by rates of miscarriages, preterm deliveries, live births and neonatal
complications. Results. Of the 25 pregnancies, 20 (80%) resulted in live
birth, 3 (12%) in spontaneous abortion and 2 (8%) were stillbirths. The mean
gestational age at delivery was 37.2 ± 1.0 weeks, mean neonatal birth weight
was 2,930.4 ± 428.0 g. Prematurity occurs in 4 (20%) live births, and there
were 4 (20%) intrauterine growth restriction with mean birth weight 2,060 ±
210.6 g. Neonatal complications were present in 6 (30%) newborns. Adverse
perinatal outcome was significantly associated with anticardiolipin IgG
antibodies (p < 0.01) and development of hypertension during pregnancy (p <
0.01). Conclusion. Despite a high incidence of adverse perinatal outcomes in
pregnancies with primary antiphospholipid syndrome, early treatment with
aspirin and low-molecular-weight heparin, combined with meticulous
fetomaternal monitoring could be associated with a relatively high
probability of favorable perinatal outcome.
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