Prospective study of perinatal outcome in pregnancies with primary antiphospholipid syndrome
Background/Aim. Pregnancies complicated with antiphospholipd syndrome are associated with the increased perinatal mortality and morbidity. The aim of this study was to assess perinatal outcome in pregnancies with primary antiphospholipd syndrome. Methods. This prospective study evaluated pe...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2014-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501408742C.pdf |
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| author | Ćetković Aleksandar Kastratović Biljana Novaković Ivana |
| author_facet | Ćetković Aleksandar Kastratović Biljana Novaković Ivana |
| author_sort | Ćetković Aleksandar |
| collection | DOAJ |
| description | Background/Aim. Pregnancies complicated with antiphospholipd syndrome are
associated with the increased perinatal mortality and morbidity. The aim of
this study was to assess perinatal outcome in pregnancies with primary
antiphospholipd syndrome. Methods. This prospective study evaluated perinatal
outcome in 25 pregnant women with antiphospholipid syndrome. After
establishing vital pregnancy all the patients were treated with
low-molecularweight heparin and aspirin. The perinatal outcome was measured
by rates of miscarriages, preterm deliveries, live births and neonatal
complications. Results. Of the 25 pregnancies, 20 (80%) resulted in live
birth, 3 (12%) in spontaneous abortion and 2 (8%) were stillbirths. The mean
gestational age at delivery was 37.2 ± 1.0 weeks, mean neonatal birth weight
was 2,930.4 ± 428.0 g. Prematurity occurs in 4 (20%) live births, and there
were 4 (20%) intrauterine growth restriction with mean birth weight 2,060 ±
210.6 g. Neonatal complications were present in 6 (30%) newborns. Adverse
perinatal outcome was significantly associated with anticardiolipin IgG
antibodies (p < 0.01) and development of hypertension during pregnancy (p <
0.01). Conclusion. Despite a high incidence of adverse perinatal outcomes in
pregnancies with primary antiphospholipid syndrome, early treatment with
aspirin and low-molecular-weight heparin, combined with meticulous
fetomaternal monitoring could be associated with a relatively high
probability of favorable perinatal outcome. |
| first_indexed | 2024-04-12T01:58:22Z |
| format | Article |
| id | doaj.art-b707211069fb42ff821a237a2a41c3fb |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2024-04-12T01:58:22Z |
| publishDate | 2014-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-b707211069fb42ff821a237a2a41c3fb2022-12-22T03:52:44ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502014-01-0171874274510.2298/VSP1408742C0042-84501408742CProspective study of perinatal outcome in pregnancies with primary antiphospholipid syndromeĆetković Aleksandar0Kastratović Biljana1Novaković Ivana2Clinical Center of Serbia, Clinic of Gynecology and Obstetrics, BelgradeFaculty of Medicine, BelgradeFaculty of Medicine, Institute of Human Genetics, BelgradeBackground/Aim. Pregnancies complicated with antiphospholipd syndrome are associated with the increased perinatal mortality and morbidity. The aim of this study was to assess perinatal outcome in pregnancies with primary antiphospholipd syndrome. Methods. This prospective study evaluated perinatal outcome in 25 pregnant women with antiphospholipid syndrome. After establishing vital pregnancy all the patients were treated with low-molecularweight heparin and aspirin. The perinatal outcome was measured by rates of miscarriages, preterm deliveries, live births and neonatal complications. Results. Of the 25 pregnancies, 20 (80%) resulted in live birth, 3 (12%) in spontaneous abortion and 2 (8%) were stillbirths. The mean gestational age at delivery was 37.2 ± 1.0 weeks, mean neonatal birth weight was 2,930.4 ± 428.0 g. Prematurity occurs in 4 (20%) live births, and there were 4 (20%) intrauterine growth restriction with mean birth weight 2,060 ± 210.6 g. Neonatal complications were present in 6 (30%) newborns. Adverse perinatal outcome was significantly associated with anticardiolipin IgG antibodies (p < 0.01) and development of hypertension during pregnancy (p < 0.01). Conclusion. Despite a high incidence of adverse perinatal outcomes in pregnancies with primary antiphospholipid syndrome, early treatment with aspirin and low-molecular-weight heparin, combined with meticulous fetomaternal monitoring could be associated with a relatively high probability of favorable perinatal outcome.http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501408742C.pdfantiphospholipid syndromepregnancy outcomeaspirinheparin, low-molecular-weight |
| spellingShingle | Ćetković Aleksandar Kastratović Biljana Novaković Ivana Prospective study of perinatal outcome in pregnancies with primary antiphospholipid syndrome Vojnosanitetski Pregled antiphospholipid syndrome pregnancy outcome aspirin heparin, low-molecular-weight |
| title | Prospective study of perinatal outcome in pregnancies with primary antiphospholipid syndrome |
| title_full | Prospective study of perinatal outcome in pregnancies with primary antiphospholipid syndrome |
| title_fullStr | Prospective study of perinatal outcome in pregnancies with primary antiphospholipid syndrome |
| title_full_unstemmed | Prospective study of perinatal outcome in pregnancies with primary antiphospholipid syndrome |
| title_short | Prospective study of perinatal outcome in pregnancies with primary antiphospholipid syndrome |
| title_sort | prospective study of perinatal outcome in pregnancies with primary antiphospholipid syndrome |
| topic | antiphospholipid syndrome pregnancy outcome aspirin heparin, low-molecular-weight |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501408742C.pdf |
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