Expression of PD-L1 through evolution phase from pre-invasive to invasive lung adenocarcinoma
Abstract Background This study evaluated programmed cell death-ligand 1 (PD-L1) expression from pre-invasive adenocarcinoma to invasive lung adenocarcinoma, aimed to investigate the potential association of PD-L1 pathway with lung adenocarcinoma early evolution. Methods We evaluated PD-L1 expression...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-023-02310-0 |
| _version_ | 1797946109190995968 |
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| author | Jiebai Zhou Huo Lin Zheng Ni Rongkui Luo Dawei Yang Mingxiang Feng Yong Zhang |
| author_facet | Jiebai Zhou Huo Lin Zheng Ni Rongkui Luo Dawei Yang Mingxiang Feng Yong Zhang |
| author_sort | Jiebai Zhou |
| collection | DOAJ |
| description | Abstract Background This study evaluated programmed cell death-ligand 1 (PD-L1) expression from pre-invasive adenocarcinoma to invasive lung adenocarcinoma, aimed to investigate the potential association of PD-L1 pathway with lung adenocarcinoma early evolution. Methods We evaluated PD-L1 expression in 1123 resected lung specimens of adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IAC) of stage IA1–IA3. PD-L1 expression was defined based on the proportion of stained tumor cells using the tumor proportion score: < 1% (negative), ≥ 1% (positive) and ≥ 50% (strongly positive). Correlations between PD-L1 expression and T stage, pathological subtype, adenocarcinoma grade, spread through air space (STAS), vascular invasion, lymphatic invasion and driven genes were analyzed. Results There was almost no PD-L1 expression in AIS or MIA. However, PD-L1 expression was correlated with invasiveness of lung adenocarcinoma. The percentages of PD-L1 positive in IA1–IA3 were 7.22%, 11.29%, and 14.20%, respectively. The strongly positive rates of PD-L1 were 0.38%, 1.64%, and 3.70% in IA1–IA3, respectively. PD-L1 expression and positive rate were also associated with poor pathological subtype and poor biological behavior, such as adenocarcinoma Grade 3, micropapillary or solid dominant subtype, STAS and vascular invasion. Finally, PD-L1 positive rate seems also corrected with driven gene ALK, ROS-1 and KRAS. Conclusions PD-L1 expression was positively correlated with the emergence of invasiveness and poor pathological subtype or biological behavior of early-stage lung adenocarcinoma. PD-L1 pathway may be involved in the early evolution of lung adenocarcinoma from AIS to IAC. |
| first_indexed | 2024-04-10T21:05:41Z |
| format | Article |
| id | doaj.art-b708a8bc412a4268923b4eb5964122bf |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-04-10T21:05:41Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-b708a8bc412a4268923b4eb5964122bf2023-01-22T12:03:42ZengBMCBMC Pulmonary Medicine1471-24662023-01-012311910.1186/s12890-023-02310-0Expression of PD-L1 through evolution phase from pre-invasive to invasive lung adenocarcinomaJiebai Zhou0Huo Lin1Zheng Ni2Rongkui Luo3Dawei Yang4Mingxiang Feng5Yong Zhang6Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan UniversityDepartment of Pulmonary and Critical Care Medicine, Shishi County HospitalDepartment of Pathology, Zhongshan Hospital, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, Fudan UniversityDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan UniversityDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan UniversityDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan UniversityAbstract Background This study evaluated programmed cell death-ligand 1 (PD-L1) expression from pre-invasive adenocarcinoma to invasive lung adenocarcinoma, aimed to investigate the potential association of PD-L1 pathway with lung adenocarcinoma early evolution. Methods We evaluated PD-L1 expression in 1123 resected lung specimens of adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IAC) of stage IA1–IA3. PD-L1 expression was defined based on the proportion of stained tumor cells using the tumor proportion score: < 1% (negative), ≥ 1% (positive) and ≥ 50% (strongly positive). Correlations between PD-L1 expression and T stage, pathological subtype, adenocarcinoma grade, spread through air space (STAS), vascular invasion, lymphatic invasion and driven genes were analyzed. Results There was almost no PD-L1 expression in AIS or MIA. However, PD-L1 expression was correlated with invasiveness of lung adenocarcinoma. The percentages of PD-L1 positive in IA1–IA3 were 7.22%, 11.29%, and 14.20%, respectively. The strongly positive rates of PD-L1 were 0.38%, 1.64%, and 3.70% in IA1–IA3, respectively. PD-L1 expression and positive rate were also associated with poor pathological subtype and poor biological behavior, such as adenocarcinoma Grade 3, micropapillary or solid dominant subtype, STAS and vascular invasion. Finally, PD-L1 positive rate seems also corrected with driven gene ALK, ROS-1 and KRAS. Conclusions PD-L1 expression was positively correlated with the emergence of invasiveness and poor pathological subtype or biological behavior of early-stage lung adenocarcinoma. PD-L1 pathway may be involved in the early evolution of lung adenocarcinoma from AIS to IAC.https://doi.org/10.1186/s12890-023-02310-0Lung cancerEarly-stagePD-L1 expressionAdenocarcinoma evolution |
| spellingShingle | Jiebai Zhou Huo Lin Zheng Ni Rongkui Luo Dawei Yang Mingxiang Feng Yong Zhang Expression of PD-L1 through evolution phase from pre-invasive to invasive lung adenocarcinoma BMC Pulmonary Medicine Lung cancer Early-stage PD-L1 expression Adenocarcinoma evolution |
| title | Expression of PD-L1 through evolution phase from pre-invasive to invasive lung adenocarcinoma |
| title_full | Expression of PD-L1 through evolution phase from pre-invasive to invasive lung adenocarcinoma |
| title_fullStr | Expression of PD-L1 through evolution phase from pre-invasive to invasive lung adenocarcinoma |
| title_full_unstemmed | Expression of PD-L1 through evolution phase from pre-invasive to invasive lung adenocarcinoma |
| title_short | Expression of PD-L1 through evolution phase from pre-invasive to invasive lung adenocarcinoma |
| title_sort | expression of pd l1 through evolution phase from pre invasive to invasive lung adenocarcinoma |
| topic | Lung cancer Early-stage PD-L1 expression Adenocarcinoma evolution |
| url | https://doi.org/10.1186/s12890-023-02310-0 |
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