ORFV infection enhances CXCL16 secretion and causes oncolysis of lung cancer cells through immunogenic apoptosis

ORFV infection enhances CXCL16 secretion and causes oncolysis of lung cancer cells through immunogenic apoptosis

Oncolytic viruses have been emerging as a promising therapeutic option for cancer patients, including lung cancer. Orf virus (ORFV), a DNA parapoxvirus, can infect its natural ungulate hosts and transmit into humans. Moreover, the ORFV has advantages of low toxicity, high targeted, self-amplificatio...

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Bibliographic Details
Main Authors: Ruixue Wang, Jingying Mo, Xiaoshan Luo, Guixian Zhang, Fang Liu, Shuhong Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Orf virus (ORFV)
lung cancer
apoptosis
immunogenic cell death (ICD)
CXCL16
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.910466/full

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