Differentiation of control and ALS mutant human iPSCs into functional skeletal muscle cells, a tool for the study of neuromuscolar diseases

Differentiation of control and ALS mutant human iPSCs into functional skeletal muscle cells, a tool for the study of neuromuscolar diseases

Amyotrophic Lateral Sclerosis (ALS) is a severe and fatal neurodegenerative disease characterized by progressive loss of motoneurons, muscle atrophy and paralysis. Recent evidence suggests that ALS should be considered as a multi-systemic disease, in which several cell types contribute to motoneuron...

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Bibliographic Details
Main Authors: Jessica Lenzi, Francesca Pagani, Riccardo De Santis, Cristina Limatola, Irene Bozzoni, Silvia Di Angelantonio, Alessandro Rosa
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Stem Cell Research
Subjects:
Induced Pluripotent Stem Cells
Amyotrophic Lateral Sclerosis
FUS/TLS
TDP-43
Skeletal muscle
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506116300666

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http://www.sciencedirect.com/science/article/pii/S1873506116300666

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