Bioinformatics analysis of immune-related prognostic genes and immunotherapy in renal clear cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is an immunogenic tumor, and investigating the immunorelated genes is essential. To investigate the immunoprognostic genes of ccRCC, we analyzed the data assimilated from a public database (The Cancer Genome Atlas (TCGA) database and the gene expression omnibu...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683592/?tool=EBI |
| _version_ | 1811211428959354880 |
|---|---|
| author | Ziwen Pan Sheng Chang Song Chen Daqiang Zhao Zhiyu Zou Linrui Dai Yibo Hou Qianqian Zhang Yuanyuan Yang Zhishui Chen Weijie Zhang Yuanyuan Zhao |
| author_facet | Ziwen Pan Sheng Chang Song Chen Daqiang Zhao Zhiyu Zou Linrui Dai Yibo Hou Qianqian Zhang Yuanyuan Yang Zhishui Chen Weijie Zhang Yuanyuan Zhao |
| author_sort | Ziwen Pan |
| collection | DOAJ |
| description | Clear cell renal cell carcinoma (ccRCC) is an immunogenic tumor, and investigating the immunorelated genes is essential. To investigate the immunoprognostic genes of ccRCC, we analyzed the data assimilated from a public database (The Cancer Genome Atlas (TCGA) database and the gene expression omnibus (GEO) database) using bioinformatics. Then, an immunoprognosis model was constructed to identify four hub genes with moderate predictive values for the prognosis of ccRCC patients. These four genes were associated with the prognosis of ccRCC patients based on Oncomine and Gena Expression Profiling Interactive Analysis (GEPIA) databases. The correlation analysis between the immune infiltrate, immune checkpoints, and immunotherapy and this immunoprognosis model showed that immune infiltration could predict the immunotherapy effects. We also conducted a quantitative real-time polymerase chain reaction analysis and found that the expressions of three hub genes were associated with tumor progression (P<0.1). In conclusion, four genes that may serve as potential biomarkers in ccRCC were identified with respect to prognosis. |
| first_indexed | 2024-04-12T05:12:53Z |
| format | Article |
| id | doaj.art-b70ab0428ef14801aa40949949dfc2cd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T05:12:53Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b70ab0428ef14801aa40949949dfc2cd2022-12-22T03:46:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-011711Bioinformatics analysis of immune-related prognostic genes and immunotherapy in renal clear cell carcinomaZiwen PanSheng ChangSong ChenDaqiang ZhaoZhiyu ZouLinrui DaiYibo HouQianqian ZhangYuanyuan YangZhishui ChenWeijie ZhangYuanyuan ZhaoClear cell renal cell carcinoma (ccRCC) is an immunogenic tumor, and investigating the immunorelated genes is essential. To investigate the immunoprognostic genes of ccRCC, we analyzed the data assimilated from a public database (The Cancer Genome Atlas (TCGA) database and the gene expression omnibus (GEO) database) using bioinformatics. Then, an immunoprognosis model was constructed to identify four hub genes with moderate predictive values for the prognosis of ccRCC patients. These four genes were associated with the prognosis of ccRCC patients based on Oncomine and Gena Expression Profiling Interactive Analysis (GEPIA) databases. The correlation analysis between the immune infiltrate, immune checkpoints, and immunotherapy and this immunoprognosis model showed that immune infiltration could predict the immunotherapy effects. We also conducted a quantitative real-time polymerase chain reaction analysis and found that the expressions of three hub genes were associated with tumor progression (P<0.1). In conclusion, four genes that may serve as potential biomarkers in ccRCC were identified with respect to prognosis.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683592/?tool=EBI |
| spellingShingle | Ziwen Pan Sheng Chang Song Chen Daqiang Zhao Zhiyu Zou Linrui Dai Yibo Hou Qianqian Zhang Yuanyuan Yang Zhishui Chen Weijie Zhang Yuanyuan Zhao Bioinformatics analysis of immune-related prognostic genes and immunotherapy in renal clear cell carcinoma PLoS ONE |
| title | Bioinformatics analysis of immune-related prognostic genes and immunotherapy in renal clear cell carcinoma |
| title_full | Bioinformatics analysis of immune-related prognostic genes and immunotherapy in renal clear cell carcinoma |
| title_fullStr | Bioinformatics analysis of immune-related prognostic genes and immunotherapy in renal clear cell carcinoma |
| title_full_unstemmed | Bioinformatics analysis of immune-related prognostic genes and immunotherapy in renal clear cell carcinoma |
| title_short | Bioinformatics analysis of immune-related prognostic genes and immunotherapy in renal clear cell carcinoma |
| title_sort | bioinformatics analysis of immune related prognostic genes and immunotherapy in renal clear cell carcinoma |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683592/?tool=EBI |
| work_keys_str_mv | AT ziwenpan bioinformaticsanalysisofimmunerelatedprognosticgenesandimmunotherapyinrenalclearcellcarcinoma AT shengchang bioinformaticsanalysisofimmunerelatedprognosticgenesandimmunotherapyinrenalclearcellcarcinoma AT songchen bioinformaticsanalysisofimmunerelatedprognosticgenesandimmunotherapyinrenalclearcellcarcinoma AT daqiangzhao bioinformaticsanalysisofimmunerelatedprognosticgenesandimmunotherapyinrenalclearcellcarcinoma AT zhiyuzou bioinformaticsanalysisofimmunerelatedprognosticgenesandimmunotherapyinrenalclearcellcarcinoma AT linruidai bioinformaticsanalysisofimmunerelatedprognosticgenesandimmunotherapyinrenalclearcellcarcinoma AT yibohou bioinformaticsanalysisofimmunerelatedprognosticgenesandimmunotherapyinrenalclearcellcarcinoma AT qianqianzhang bioinformaticsanalysisofimmunerelatedprognosticgenesandimmunotherapyinrenalclearcellcarcinoma AT yuanyuanyang bioinformaticsanalysisofimmunerelatedprognosticgenesandimmunotherapyinrenalclearcellcarcinoma AT zhishuichen bioinformaticsanalysisofimmunerelatedprognosticgenesandimmunotherapyinrenalclearcellcarcinoma AT weijiezhang bioinformaticsanalysisofimmunerelatedprognosticgenesandimmunotherapyinrenalclearcellcarcinoma AT yuanyuanzhao bioinformaticsanalysisofimmunerelatedprognosticgenesandimmunotherapyinrenalclearcellcarcinoma |