The influence of montelukast on the autonomic nervous system activity in rats with cyclophosphamide-induced hemorrhagic cystitis
The complex pathogenesis of cyclophosphamide-induced hemorrhagic cystitis involves arachidonic acid-derived inflammatory mediators, among them leukotrienes. Montelukast, a leukotriene receptor antagonist, is reported to exert an alleviatory effect in the course of cystitis associated with overactive...
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| Format: | Article |
| Language: | English |
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Sciendo
2015-09-01
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| Series: | Current Issues in Pharmacy and Medical Sciences |
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| Online Access: | https://doi.org/10.1515/cipms-2015-0066 |
| _version_ | 1818728041447161856 |
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| author | Dobrek Lukasz Skowron Beata Baranowska Agnieszka Thor Piotr Jan |
| author_facet | Dobrek Lukasz Skowron Beata Baranowska Agnieszka Thor Piotr Jan |
| author_sort | Dobrek Lukasz |
| collection | DOAJ |
| description | The complex pathogenesis of cyclophosphamide-induced hemorrhagic cystitis involves arachidonic acid-derived inflammatory mediators, among them leukotrienes. Montelukast, a leukotriene receptor antagonist, is reported to exert an alleviatory effect in the course of cystitis associated with overactive bladder symptoms. The aim of this study was to verify whether the effect of montelukast is also associated with its influence on autonomic activity. The experiment included 20 rats with cyclophosphamide-induced hemorrhagic cystitis (75 mg/kg, four doses every second day), among them, 10 treated with oral montelukast (10 mg/kg for 8 days) and 10 controls. Time and frequency domain analyses of heart rate variability (HRV) were conducted in all the rats as an indirect measure of their autonomic activity. The montelukast-treated animals showed an increase in root mean square of successive differences (rMSSD), as well as an increase in HRV spectrum total power (TP) and power of very low (VLF) spectral component. This suggests that due to its anti-inflammatory and its anti-leukotriene effect, montelukast improves overall autonomic activity, with no preferential influence on either the sympathetic or parasympathetic part. Furthermore, the increase in VLF corresponds to attenuation of inflammatory response. In conclusion, this study showed that aside from its antagonistic effect on leukotriene receptors, montelukast can also modulate autonomic activity. |
| first_indexed | 2024-12-17T22:23:41Z |
| format | Article |
| id | doaj.art-b70ade1375ef46da9bf12a3ced6b4cf4 |
| institution | Directory Open Access Journal |
| issn | 2300-6676 |
| language | English |
| last_indexed | 2024-12-17T22:23:41Z |
| publishDate | 2015-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Current Issues in Pharmacy and Medical Sciences |
| spelling | doaj.art-b70ade1375ef46da9bf12a3ced6b4cf42022-12-21T21:30:25ZengSciendoCurrent Issues in Pharmacy and Medical Sciences2300-66762015-09-0128317017510.1515/cipms-2015-0066cipms-2015-0066The influence of montelukast on the autonomic nervous system activity in rats with cyclophosphamide-induced hemorrhagic cystitisDobrek Lukasz0Skowron Beata1Baranowska Agnieszka2Thor Piotr Jan3Department of Pathophysiology, Jagiellonian University Collegium Medicum, Czysta 18, 31-121 Krakow, PolandDepartment of Pathophysiology, Jagiellonian University Collegium Medicum, Czysta 18, 31-121 Krakow, PolandDepartment of Pathophysiology, Jagiellonian University Collegium Medicum, Czysta 18, 31-121 Krakow, PolandDepartment of Pathophysiology, Jagiellonian University Collegium Medicum, Czysta 18, 31-121 Krakow, PolandThe complex pathogenesis of cyclophosphamide-induced hemorrhagic cystitis involves arachidonic acid-derived inflammatory mediators, among them leukotrienes. Montelukast, a leukotriene receptor antagonist, is reported to exert an alleviatory effect in the course of cystitis associated with overactive bladder symptoms. The aim of this study was to verify whether the effect of montelukast is also associated with its influence on autonomic activity. The experiment included 20 rats with cyclophosphamide-induced hemorrhagic cystitis (75 mg/kg, four doses every second day), among them, 10 treated with oral montelukast (10 mg/kg for 8 days) and 10 controls. Time and frequency domain analyses of heart rate variability (HRV) were conducted in all the rats as an indirect measure of their autonomic activity. The montelukast-treated animals showed an increase in root mean square of successive differences (rMSSD), as well as an increase in HRV spectrum total power (TP) and power of very low (VLF) spectral component. This suggests that due to its anti-inflammatory and its anti-leukotriene effect, montelukast improves overall autonomic activity, with no preferential influence on either the sympathetic or parasympathetic part. Furthermore, the increase in VLF corresponds to attenuation of inflammatory response. In conclusion, this study showed that aside from its antagonistic effect on leukotriene receptors, montelukast can also modulate autonomic activity.https://doi.org/10.1515/cipms-2015-0066heart rate variabilityautonomic nervous systemcystitismontelukast |
| spellingShingle | Dobrek Lukasz Skowron Beata Baranowska Agnieszka Thor Piotr Jan The influence of montelukast on the autonomic nervous system activity in rats with cyclophosphamide-induced hemorrhagic cystitis Current Issues in Pharmacy and Medical Sciences heart rate variability autonomic nervous system cystitis montelukast |
| title | The influence of montelukast on the autonomic nervous system activity in rats with cyclophosphamide-induced hemorrhagic cystitis |
| title_full | The influence of montelukast on the autonomic nervous system activity in rats with cyclophosphamide-induced hemorrhagic cystitis |
| title_fullStr | The influence of montelukast on the autonomic nervous system activity in rats with cyclophosphamide-induced hemorrhagic cystitis |
| title_full_unstemmed | The influence of montelukast on the autonomic nervous system activity in rats with cyclophosphamide-induced hemorrhagic cystitis |
| title_short | The influence of montelukast on the autonomic nervous system activity in rats with cyclophosphamide-induced hemorrhagic cystitis |
| title_sort | influence of montelukast on the autonomic nervous system activity in rats with cyclophosphamide induced hemorrhagic cystitis |
| topic | heart rate variability autonomic nervous system cystitis montelukast |
| url | https://doi.org/10.1515/cipms-2015-0066 |
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