Gut microbiota modulates visceral sensitivity through calcitonin gene-related peptide (CGRP) production

Gut microbiota modulates visceral sensitivity through calcitonin gene-related peptide (CGRP) production

ABSTRACTAbdominal pain is common in patients with gastrointestinal disorders, but its pathophysiology is unclear, in part due to poor understanding of basic mechanisms underlying visceral sensitivity. Accumulating evidence suggests that gut microbiota is an important determinant of visceral sensitiv...

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Bibliographic Details
Main Authors: Julien Pujo, Giada De Palma, Jun Lu, Heather J. Galipeau, Michael G. Surette, Stephen M. Collins, Premysl Bercik
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Gut Microbes
Subjects:
Visceral pain
bacteria
germ-free
dorsal root ganglia (DRG)
substance P (SP)
calcitonin-gene-related peptide (CGRP)
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2023.2188874

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