Transcription factor CASZ1 increases an oncogenic transcriptional process in tumorigenesis and progression of glioma cells
Abstract As a transcription factor, the role of CASZ1 in different entities is inconsistent. Glioma is one of the leading causes of cancer death worldwide. Its prognostic relevance and biological functions in glioma remain obscure. We focused on the role, mechanism, and prognostic value of CASZ1 in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-12-01
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| Series: | MedComm |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mco2.182 |
| _version_ | 1811300584454619136 |
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| author | Chaofu Mao Chengying Huang Zhicheng Hu Shanqiang Qu |
| author_facet | Chaofu Mao Chengying Huang Zhicheng Hu Shanqiang Qu |
| author_sort | Chaofu Mao |
| collection | DOAJ |
| description | Abstract As a transcription factor, the role of CASZ1 in different entities is inconsistent. Glioma is one of the leading causes of cancer death worldwide. Its prognostic relevance and biological functions in glioma remain obscure. We focused on the role, mechanism, and prognostic value of CASZ1 in glioma cells. Herein, CASZ1 was identified as a novel potential oncogene in glioma tissues from GEO and TCGA datasets. CASZ1 was highly expressed in glioma tissues, predicting poor prognosis in glioma patients. Knockdown of CASZ1 inhibited proliferation and invasion in vitro, whereas upregulation of CASZ1 presented opposite results. Overexpression of CASZ1 increased transcriptional process of target gene p75NTR. CASZ1 was the potential transcriptional regulators for p75NTR. In addition, the p75NTR expression is essential for CASZ1 to exert its function as an oncogene. Our findings indicate that highly expressed CASZ1 in glioma cells acts as a pro‐oncogene factor in gliomas via regulating transcriptional process of target gene p75NTR, which was identified as an unfavorable prognostic marker in patients with gliomas. CASZ1 is expected to become a novel target for the treatment of gliomas. |
| first_indexed | 2024-04-13T06:53:26Z |
| format | Article |
| id | doaj.art-b70c1baa14014694b891d609ba61a842 |
| institution | Directory Open Access Journal |
| issn | 2688-2663 |
| language | English |
| last_indexed | 2024-04-13T06:53:26Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj.art-b70c1baa14014694b891d609ba61a8422022-12-22T02:57:20ZengWileyMedComm2688-26632022-12-0134n/an/a10.1002/mco2.182Transcription factor CASZ1 increases an oncogenic transcriptional process in tumorigenesis and progression of glioma cellsChaofu Mao0Chengying Huang1Zhicheng Hu2Shanqiang Qu3Department of Neurosurgery Nanfang Hospital Southern Medical University Guangzhou Guangdong People's Republic of ChinaDepartment of Obstetrics and Gynecology, Baiyun Branch Nanfang Hospital Southern Medical University Guangzhou Guangdong People's Republic of ChinaDepartment of Burn Surgery First Affiliated Hospital Sun Yat‐sen University Guangzhou Guangdong People's Republic of ChinaDepartment of Neurosurgery Nanfang Hospital Southern Medical University Guangzhou Guangdong People's Republic of ChinaAbstract As a transcription factor, the role of CASZ1 in different entities is inconsistent. Glioma is one of the leading causes of cancer death worldwide. Its prognostic relevance and biological functions in glioma remain obscure. We focused on the role, mechanism, and prognostic value of CASZ1 in glioma cells. Herein, CASZ1 was identified as a novel potential oncogene in glioma tissues from GEO and TCGA datasets. CASZ1 was highly expressed in glioma tissues, predicting poor prognosis in glioma patients. Knockdown of CASZ1 inhibited proliferation and invasion in vitro, whereas upregulation of CASZ1 presented opposite results. Overexpression of CASZ1 increased transcriptional process of target gene p75NTR. CASZ1 was the potential transcriptional regulators for p75NTR. In addition, the p75NTR expression is essential for CASZ1 to exert its function as an oncogene. Our findings indicate that highly expressed CASZ1 in glioma cells acts as a pro‐oncogene factor in gliomas via regulating transcriptional process of target gene p75NTR, which was identified as an unfavorable prognostic marker in patients with gliomas. CASZ1 is expected to become a novel target for the treatment of gliomas.https://doi.org/10.1002/mco2.182CASZ1gliomatherapeutic targets |
| spellingShingle | Chaofu Mao Chengying Huang Zhicheng Hu Shanqiang Qu Transcription factor CASZ1 increases an oncogenic transcriptional process in tumorigenesis and progression of glioma cells MedComm CASZ1 glioma therapeutic targets |
| title | Transcription factor CASZ1 increases an oncogenic transcriptional process in tumorigenesis and progression of glioma cells |
| title_full | Transcription factor CASZ1 increases an oncogenic transcriptional process in tumorigenesis and progression of glioma cells |
| title_fullStr | Transcription factor CASZ1 increases an oncogenic transcriptional process in tumorigenesis and progression of glioma cells |
| title_full_unstemmed | Transcription factor CASZ1 increases an oncogenic transcriptional process in tumorigenesis and progression of glioma cells |
| title_short | Transcription factor CASZ1 increases an oncogenic transcriptional process in tumorigenesis and progression of glioma cells |
| title_sort | transcription factor casz1 increases an oncogenic transcriptional process in tumorigenesis and progression of glioma cells |
| topic | CASZ1 glioma therapeutic targets |
| url | https://doi.org/10.1002/mco2.182 |
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