In vivo antidiabetic effects of phenolic compounds of spinach, mustard, and cabbage leaves in mice
Leafy vegetables are considered to have health-promoting potentials, mainly attributed to bioactive phenolic compounds. The antidiabetic effects of spinach, mustard, and cabbage were studied by feeding their phenolic-rich aqueous extracts to alloxan-induced diabetic mice. The antioxidant, biochemica...
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Format: | Article |
Language: | English |
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Elsevier
2023-06-01
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Series: | Heliyon |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023038239 |
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author | Arif Mehmood Alam Zeb Muhammad Khalil Ateeq |
author_facet | Arif Mehmood Alam Zeb Muhammad Khalil Ateeq |
author_sort | Arif Mehmood |
collection | DOAJ |
description | Leafy vegetables are considered to have health-promoting potentials, mainly attributed to bioactive phenolic compounds. The antidiabetic effects of spinach, mustard, and cabbage were studied by feeding their phenolic-rich aqueous extracts to alloxan-induced diabetic mice. The antioxidant, biochemical, histopathological, and hematological indices of the control, diabetic, and treated mice were studied. Phenolic compounds present in the extracts were identified and quantified using HPLC-DAD. Results showed ten, nineteen, and eleven phenolic compounds in spinach, mustard, and cabbage leave aqueous extracts, respectively. The body weight, tissue total glutathione (GSH) contents, fasting blood sugar, liver function tests, renal function tests, and lipid profile of the mice were affected by diabetes and were significantly improved by the extract treatments. Likewise, hematological indices and tissues histological studies also showed recovery from diabetic stress in treated mice. The study's findings highlight that the selected leafy vegetables potentially mitigate diabetic complications. Among the studied vegetables, cabbage extract was comparatively more active in ameliorating diabetic stress. |
first_indexed | 2024-03-13T08:24:07Z |
format | Article |
id | doaj.art-b70e0a9d4c5b4a70ac705f02dd92e00b |
institution | Directory Open Access Journal |
issn | 2405-8440 |
language | English |
last_indexed | 2024-03-13T08:24:07Z |
publishDate | 2023-06-01 |
publisher | Elsevier |
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series | Heliyon |
spelling | doaj.art-b70e0a9d4c5b4a70ac705f02dd92e00b2023-05-31T04:47:24ZengElsevierHeliyon2405-84402023-06-0196e16616In vivo antidiabetic effects of phenolic compounds of spinach, mustard, and cabbage leaves in miceArif Mehmood0Alam Zeb1Muhammad Khalil Ateeq2Department of Biotechnology, University of Malakand, Chakdara, Khyber Pakhtunkhwa, PakistanDepartment of Biochemistry, University of Malakand, Chakdara, Khyber Pakhtunkhwa, Pakistan; Corresponding author.Department of Basic Sciences, University of Veterinary and Animals Sciences, Lahore, PakistanLeafy vegetables are considered to have health-promoting potentials, mainly attributed to bioactive phenolic compounds. The antidiabetic effects of spinach, mustard, and cabbage were studied by feeding their phenolic-rich aqueous extracts to alloxan-induced diabetic mice. The antioxidant, biochemical, histopathological, and hematological indices of the control, diabetic, and treated mice were studied. Phenolic compounds present in the extracts were identified and quantified using HPLC-DAD. Results showed ten, nineteen, and eleven phenolic compounds in spinach, mustard, and cabbage leave aqueous extracts, respectively. The body weight, tissue total glutathione (GSH) contents, fasting blood sugar, liver function tests, renal function tests, and lipid profile of the mice were affected by diabetes and were significantly improved by the extract treatments. Likewise, hematological indices and tissues histological studies also showed recovery from diabetic stress in treated mice. The study's findings highlight that the selected leafy vegetables potentially mitigate diabetic complications. Among the studied vegetables, cabbage extract was comparatively more active in ameliorating diabetic stress.http://www.sciencedirect.com/science/article/pii/S2405844023038239DiabetesSpinachMustardCabbagePhenolic compoundsAntidiabetic potential |
spellingShingle | Arif Mehmood Alam Zeb Muhammad Khalil Ateeq In vivo antidiabetic effects of phenolic compounds of spinach, mustard, and cabbage leaves in mice Heliyon Diabetes Spinach Mustard Cabbage Phenolic compounds Antidiabetic potential |
title | In vivo antidiabetic effects of phenolic compounds of spinach, mustard, and cabbage leaves in mice |
title_full | In vivo antidiabetic effects of phenolic compounds of spinach, mustard, and cabbage leaves in mice |
title_fullStr | In vivo antidiabetic effects of phenolic compounds of spinach, mustard, and cabbage leaves in mice |
title_full_unstemmed | In vivo antidiabetic effects of phenolic compounds of spinach, mustard, and cabbage leaves in mice |
title_short | In vivo antidiabetic effects of phenolic compounds of spinach, mustard, and cabbage leaves in mice |
title_sort | in vivo antidiabetic effects of phenolic compounds of spinach mustard and cabbage leaves in mice |
topic | Diabetes Spinach Mustard Cabbage Phenolic compounds Antidiabetic potential |
url | http://www.sciencedirect.com/science/article/pii/S2405844023038239 |
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