The immunity protection of intestine induced by pseudorabies virus del gI/gE/TK in piglets
Compared to the classical strain of Pseudorabies virus (PRV), the PRV variant exhibits stronger transmissibility and pathogenicity, causing immense disasters for the global pig industry. Based on this variant, our laboratory has preliminarily constructed a modified pseudorabies virus with deletions...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1295524/full |
| _version_ | 1797365532610002944 |
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| author | Yang Zhang Lei Xu Qian Tao Zheyan Liu Jianhua Wen Tong Xu Siyuan Lai Yanru Ai Zhiwen Xu Zhiwen Xu Ling Zhu Ling Zhu |
| author_facet | Yang Zhang Lei Xu Qian Tao Zheyan Liu Jianhua Wen Tong Xu Siyuan Lai Yanru Ai Zhiwen Xu Zhiwen Xu Ling Zhu Ling Zhu |
| author_sort | Yang Zhang |
| collection | DOAJ |
| description | Compared to the classical strain of Pseudorabies virus (PRV), the PRV variant exhibits stronger transmissibility and pathogenicity, causing immense disasters for the global pig industry. Based on this variant, our laboratory has preliminarily constructed a modified pseudorabies virus with deletions in the gE/gI/TK genes. In this study, the protective efficacy of PRV XJ del gI/gE/TK against piglet intestinal damage was evaluated. The results demonstrated that piglets immunized with PRV XJ del gI/gE/TK exhibited alleviated intestinal damage caused by the PRV XJ variant strain. This included reduced viral load, suppressed inflammation, and maintenance of intestinal structure and function. Additionally, PRV XJ del gI/gE/TK also strongly activated the innate immune response in the intestines, increasing the expression of antiviral factor mRNA and the secretion of SIgA to counteract the attack of the PRV XJ variant strain. Our study indicates that PRV XJ del gI/gE/TK can inhibit intestinal damage caused by PRV XJ variant strain and activate the innate immune response in the intestines. |
| first_indexed | 2024-03-08T16:50:19Z |
| format | Article |
| id | doaj.art-b70e4407ac4a48f2b7db738dc67fe5fe |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-08T16:50:19Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-b70e4407ac4a48f2b7db738dc67fe5fe2024-01-05T04:57:17ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-01-011410.3389/fmicb.2023.12955241295524The immunity protection of intestine induced by pseudorabies virus del gI/gE/TK in pigletsYang Zhang0Lei Xu1Qian Tao2Zheyan Liu3Jianhua Wen4Tong Xu5Siyuan Lai6Yanru Ai7Zhiwen Xu8Zhiwen Xu9Ling Zhu10Ling Zhu11College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, ChinaCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, ChinaCompared to the classical strain of Pseudorabies virus (PRV), the PRV variant exhibits stronger transmissibility and pathogenicity, causing immense disasters for the global pig industry. Based on this variant, our laboratory has preliminarily constructed a modified pseudorabies virus with deletions in the gE/gI/TK genes. In this study, the protective efficacy of PRV XJ del gI/gE/TK against piglet intestinal damage was evaluated. The results demonstrated that piglets immunized with PRV XJ del gI/gE/TK exhibited alleviated intestinal damage caused by the PRV XJ variant strain. This included reduced viral load, suppressed inflammation, and maintenance of intestinal structure and function. Additionally, PRV XJ del gI/gE/TK also strongly activated the innate immune response in the intestines, increasing the expression of antiviral factor mRNA and the secretion of SIgA to counteract the attack of the PRV XJ variant strain. Our study indicates that PRV XJ del gI/gE/TK can inhibit intestinal damage caused by PRV XJ variant strain and activate the innate immune response in the intestines.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1295524/fullpseudorabies virusintestinal damageintestinal immunityinflammationintestinal barrier |
| spellingShingle | Yang Zhang Lei Xu Qian Tao Zheyan Liu Jianhua Wen Tong Xu Siyuan Lai Yanru Ai Zhiwen Xu Zhiwen Xu Ling Zhu Ling Zhu The immunity protection of intestine induced by pseudorabies virus del gI/gE/TK in piglets Frontiers in Microbiology pseudorabies virus intestinal damage intestinal immunity inflammation intestinal barrier |
| title | The immunity protection of intestine induced by pseudorabies virus del gI/gE/TK in piglets |
| title_full | The immunity protection of intestine induced by pseudorabies virus del gI/gE/TK in piglets |
| title_fullStr | The immunity protection of intestine induced by pseudorabies virus del gI/gE/TK in piglets |
| title_full_unstemmed | The immunity protection of intestine induced by pseudorabies virus del gI/gE/TK in piglets |
| title_short | The immunity protection of intestine induced by pseudorabies virus del gI/gE/TK in piglets |
| title_sort | immunity protection of intestine induced by pseudorabies virus del gi ge tk in piglets |
| topic | pseudorabies virus intestinal damage intestinal immunity inflammation intestinal barrier |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1295524/full |
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