Solubility enhancing lipid-based vehicles for artemether and lumefantrine destined for the possible treatment of induced malaria and inflammation: in vitro and in vivo evaluations

Solubility enhancing lipid-based vehicles for artemether and lumefantrine destined for the possible treatment of induced malaria and inflammation: in vitro and in vivo evaluations

Abstract Background The lipid self-emulsifying system has been advanced as a promising delivery vehicle for improving the solubility and bioavailability of artemether and lumefantrine. However, the observed kinetic instability (propensity of lumefantrine to rapid crystallisation from nano-scale drop...

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Bibliographic Details
Main Authors: Onyinyechi Lydia Ugorji, Ikechukwu Virgilius Onyishi, Julie Ngozichukwuka Onwodi, Christiania Moji Adeyeye, Uzochukwu Gospel Ukachukwu, Nicholas Chinedu Obitte
Format: Article
Language:English
Published: SpringerOpen 2024-01-01
Series:Beni-Suef University Journal of Basic and Applied Sciences
Subjects:
Lipid self-emulsifying system (LSES)
Artemether (ART)
Lumefantrine (LUM)
Neusilin FH2
Anti-malarial
Anti-inflammatory
Online Access:https://doi.org/10.1186/s43088-023-00446-w

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