T-cell specific upregulation of Sema4A as risk factor for autoimmunity in systemic lupus erythematosus and rheumatoid arthritis

T-cell specific upregulation of Sema4A as risk factor for autoimmunity in systemic lupus erythematosus and rheumatoid arthritis

The aim of the present study was to evaluate the impact of SEMA4A genetic variants on expression of sema4A protein and its relation to autoimmunity development in Systemic Lupus Erythematosus and Rheumatoid Arthritis patients. A total of 541 SLE patients, 390 RA patients and 607 healthy individuals...

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Main Authors: Catarina Addobbati Jordão Cavalcanti, Vanessa Germoglio, Jaqueline de Azevêdo Silva, Nadine Glesse, Priscila Vianna, Giovana Cechim, Odirlei Andre Monticielo, Ricardo Machado Xavier, João Carlos Tavares Brenol, Claiton Viegas Brenol, Thiago Sotero Fragoso, Alexandre Domingues Barbosa, Ângela Luiza Branco Pinto Duarte, Renê Donizeti Ribeiro Oliveira, Paulo Louzada-Júnior, Eduardo Antônio Donadi, José Artur Bogo Chies, Sergio Crovella, Paula Sandrin-Garcia
Format: Article
Language:English
Published: Taylor & Francis Group 2020-02-01
Series:Autoimmunity
Subjects:
sema4a
systemic lupus erythematosus
rheumatoid arthritis
polymorphism
t cells
Online Access:http://dx.doi.org/10.1080/08916934.2019.1704273

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