Crosstalk between Serum and Skin Sphingolipids in Psoriasis
Psoriasis is a chronic, complex, immunological disorder, which may lead to many different systemic complications. Sphingolipids, including ceramide, are bioactive lipids, which take part in the regulation of immune reactions, cell growth, and apoptosis. Twenty psoriatic patients and twenty-eight con...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/19/14872 |
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| author | Mateusz Matwiejuk Hanna Myśliwiec Bartlomiej Lukaszuk Marta Lewoc Hend Malla Piotr Myśliwiec Jacek Dadan Adrian Chabowski Iwona Flisiak |
| author_facet | Mateusz Matwiejuk Hanna Myśliwiec Bartlomiej Lukaszuk Marta Lewoc Hend Malla Piotr Myśliwiec Jacek Dadan Adrian Chabowski Iwona Flisiak |
| author_sort | Mateusz Matwiejuk |
| collection | DOAJ |
| description | Psoriasis is a chronic, complex, immunological disorder, which may lead to many different systemic complications. Sphingolipids, including ceramide, are bioactive lipids, which take part in the regulation of immune reactions, cell growth, and apoptosis. Twenty psoriatic patients and twenty-eight control subjects were included in the study. Skin (both lesional and non-lesional) and serum samples were collected from both the control group and the psoriatic patients. The levels of sphingosine (SFO), sphingosine-1-phosphate (S1P), sphingomyelin, sphinganine (SFA), sphinganine-1-phosphate (SFA1P), and ceramide (CER) were assessed in both tissue (t) and serum (s) samples using high-performance liquid chromatography (HPLC). We identified elevated serum levels of SFO, S1P, SFA, and SFA1P in psoriatic patients when compared to healthy individuals. As far as the lesional skin and serum of psoriatic patients are concerned, we demonstrated positive associations between CER_t and CER_s, SFA_t and CER_s, and SFO_t and CER_s. Additionally, we found negative correlations in the non-lesional skin and serum of psoriatic patients, including SFO_t vs. SFO_s, CER_t vs. SFA_s, CER_t vs. SFO_s, and SFO_t vs. SFA_s. Finally, we observed a positive correlation between S1P and SFA1P in both the serum samples of psoriatic patients and the serum samples of the control group. In this study, we did not observe any correlations between psoriasis area and severity index (PASI) scores and sphingolipid levels. In conclusion, our findings indicate an interplay between skin and serum lipids in psoriatic patients, which is not observed in healthy individuals. |
| first_indexed | 2024-03-10T21:43:02Z |
| format | Article |
| id | doaj.art-b711d0704aa6422cafea6b30eb8d8077 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:43:02Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b711d0704aa6422cafea6b30eb8d80772023-11-19T14:31:54ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-10-0124191487210.3390/ijms241914872Crosstalk between Serum and Skin Sphingolipids in PsoriasisMateusz Matwiejuk0Hanna Myśliwiec1Bartlomiej Lukaszuk2Marta Lewoc3Hend Malla4Piotr Myśliwiec5Jacek Dadan6Adrian Chabowski7Iwona Flisiak8Department of Dermatology and Venereology, Medical University of Bialystok, 15-540 Bialystok, PolandDepartment of Dermatology and Venereology, Medical University of Bialystok, 15-540 Bialystok, PolandDepartment of Physiology, Medical University of Bialystok, 15-222 Bialystok, Poland1st Clinical Department of General and Endocrine Surgery, Medical University of Bialystok, 15-276 Bialystok, Poland1st Clinical Department of General and Endocrine Surgery, Medical University of Bialystok, 15-276 Bialystok, Poland1st Clinical Department of General and Endocrine Surgery, Medical University of Bialystok, 15-276 Bialystok, Poland1st Clinical Department of General and Endocrine Surgery, Medical University of Bialystok, 15-276 Bialystok, PolandDepartment of Physiology, Medical University of Bialystok, 15-222 Bialystok, PolandDepartment of Dermatology and Venereology, Medical University of Bialystok, 15-540 Bialystok, PolandPsoriasis is a chronic, complex, immunological disorder, which may lead to many different systemic complications. Sphingolipids, including ceramide, are bioactive lipids, which take part in the regulation of immune reactions, cell growth, and apoptosis. Twenty psoriatic patients and twenty-eight control subjects were included in the study. Skin (both lesional and non-lesional) and serum samples were collected from both the control group and the psoriatic patients. The levels of sphingosine (SFO), sphingosine-1-phosphate (S1P), sphingomyelin, sphinganine (SFA), sphinganine-1-phosphate (SFA1P), and ceramide (CER) were assessed in both tissue (t) and serum (s) samples using high-performance liquid chromatography (HPLC). We identified elevated serum levels of SFO, S1P, SFA, and SFA1P in psoriatic patients when compared to healthy individuals. As far as the lesional skin and serum of psoriatic patients are concerned, we demonstrated positive associations between CER_t and CER_s, SFA_t and CER_s, and SFO_t and CER_s. Additionally, we found negative correlations in the non-lesional skin and serum of psoriatic patients, including SFO_t vs. SFO_s, CER_t vs. SFA_s, CER_t vs. SFO_s, and SFO_t vs. SFA_s. Finally, we observed a positive correlation between S1P and SFA1P in both the serum samples of psoriatic patients and the serum samples of the control group. In this study, we did not observe any correlations between psoriasis area and severity index (PASI) scores and sphingolipid levels. In conclusion, our findings indicate an interplay between skin and serum lipids in psoriatic patients, which is not observed in healthy individuals.https://www.mdpi.com/1422-0067/24/19/14872psoriasissphingosine-1-phosphatesphinganinesphingosinesphinganine-1-phosphateceramide |
| spellingShingle | Mateusz Matwiejuk Hanna Myśliwiec Bartlomiej Lukaszuk Marta Lewoc Hend Malla Piotr Myśliwiec Jacek Dadan Adrian Chabowski Iwona Flisiak Crosstalk between Serum and Skin Sphingolipids in Psoriasis International Journal of Molecular Sciences psoriasis sphingosine-1-phosphate sphinganine sphingosine sphinganine-1-phosphate ceramide |
| title | Crosstalk between Serum and Skin Sphingolipids in Psoriasis |
| title_full | Crosstalk between Serum and Skin Sphingolipids in Psoriasis |
| title_fullStr | Crosstalk between Serum and Skin Sphingolipids in Psoriasis |
| title_full_unstemmed | Crosstalk between Serum and Skin Sphingolipids in Psoriasis |
| title_short | Crosstalk between Serum and Skin Sphingolipids in Psoriasis |
| title_sort | crosstalk between serum and skin sphingolipids in psoriasis |
| topic | psoriasis sphingosine-1-phosphate sphinganine sphingosine sphinganine-1-phosphate ceramide |
| url | https://www.mdpi.com/1422-0067/24/19/14872 |
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