Synthesis of some 3-(thiazol- 4-yl)-4-hydroxy coumarines
In this work, an easy and efficient procedure for the synthesis of eight 3-(thiazol-4-yl)-4-hydroxychromen-2-one derivatives is presented. 3-Acetyl-4-hydroxychromen- 2-one (1) was brominated with phenyltrimethylammonium tribromide to afford 3-(2-bromoacetyl)-4-hydroxychromen-2-one (2). Compound 2 re...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Serbian Chemical Society
2004-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2004/0352-51390405319S.pdf |
| Summary: | In this work, an easy and efficient procedure for the synthesis of eight 3-(thiazol-4-yl)-4-hydroxychromen-2-one derivatives is presented. 3-Acetyl-4-hydroxychromen- 2-one (1) was brominated with phenyltrimethylammonium tribromide to afford 3-(2-bromoacetyl)-4-hydroxychromen-2-one (2). Compound 2 reacts with thiourea, thioacetamide and ammonium dithiocarbamate to afford 3-(2-aminothiazol- 4-yl)-4-hydroxychromen-2-one (3) 4-hydroxy-3-(2-methylthiazol-4-yl)chromen- 2-one (4a) and 4-hydroxy-3-(2-mercaptothiazol-4-yl)chromen-2-one (5), respectively. In a similar manner, compound 2 was treated with four mono-N-substituted thioureas and thiobenzamide to give the corresponding 3-(thiazol-4-yl)-4-hydroxychromen- 2-one derivatives. |
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| ISSN: | 0352-5139 1820-7421 |