PREVENTIVE ANTIEPILEPTIC THERAPY IN PATIENTS WITH TUBEROUS SCLEROSIS
Background. Early detection of epileptiform activity on the electroencephalogram (EEG) and preventive antiepileptic therapy in patients with tuberous sclerosis (TS) help to avoid the development of severe forms of epilepsy as well as cognitive disorders associated with it.Materials and methods. Seve...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2017-08-01
|
| Series: | Русский журнал детской неврологии |
| Subjects: | |
| Online Access: | https://rjdn.abvpress.ru/jour/article/view/210 |
| _version_ | 1797874493213900800 |
|---|---|
| author | A. V. Grigoryeva M. Yu. Dorofeeva Z. K. Gorchkhanova V. S. Perminov E. D. Belousova |
| author_facet | A. V. Grigoryeva M. Yu. Dorofeeva Z. K. Gorchkhanova V. S. Perminov E. D. Belousova |
| author_sort | A. V. Grigoryeva |
| collection | DOAJ |
| description | Background. Early detection of epileptiform activity on the electroencephalogram (EEG) and preventive antiepileptic therapy in patients with tuberous sclerosis (TS) help to avoid the development of severe forms of epilepsy as well as cognitive disorders associated with it.Materials and methods. Seventeen patients with TS underwent preventive antiepileptic treatment in the Research and Clinical Institute for Pediatrics named after Y.E Vel’tishev. All patients were diagnosed with TS during their first months of life. The diagnosed was based on the detection of cardiac rhabdomyomas and hypopigmentation spots and then confirmed by a genetic test. Antiepileptic drugs (AED) (vigabatrin in 7 patients, valproic acid in 7 patients and levetiracetam in 2 patients) were administered after detection of epileptiform activity in the routine EEG (EEG was performed monthly).Results. Preventive therapy with valproic acid and levetiracetam was found to be ineffective: 4 out of 7 patients on valproic acid and 1 out of 2 patients on levetiracetam developed epilepsy. All of them were later diagnosed with delayed psychological development and delayed speech development. Among 7 patients receiving vigabatrin, only 1 patient developed epilepsy, but did not have any developmental disorders later.Conclusion. Despite vigabatrin is not registered in the Russian Federation, it should be used as an agent for preventive antiepileptic therapy in patients with TS. This approach ensures more favorable long-term results in terms of cognitive functions and psychological development, thus, providing a better quality of life. |
| first_indexed | 2024-04-10T01:31:54Z |
| format | Article |
| id | doaj.art-b71390b66f954af88600245bca3ecafe |
| institution | Directory Open Access Journal |
| issn | 2073-8803 2412-9178 |
| language | Russian |
| last_indexed | 2024-04-10T01:31:54Z |
| publishDate | 2017-08-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Русский журнал детской неврологии |
| spelling | doaj.art-b71390b66f954af88600245bca3ecafe2023-03-13T09:30:12ZrusABV-pressРусский журнал детской неврологии2073-88032412-91782017-08-01122343910.17650/2073-8803-2017-12-2-34-39151PREVENTIVE ANTIEPILEPTIC THERAPY IN PATIENTS WITH TUBEROUS SCLEROSISA. V. Grigoryeva0M. Yu. Dorofeeva1Z. K. Gorchkhanova2V. S. Perminov3E. D. Belousova4ГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииBackground. Early detection of epileptiform activity on the electroencephalogram (EEG) and preventive antiepileptic therapy in patients with tuberous sclerosis (TS) help to avoid the development of severe forms of epilepsy as well as cognitive disorders associated with it.Materials and methods. Seventeen patients with TS underwent preventive antiepileptic treatment in the Research and Clinical Institute for Pediatrics named after Y.E Vel’tishev. All patients were diagnosed with TS during their first months of life. The diagnosed was based on the detection of cardiac rhabdomyomas and hypopigmentation spots and then confirmed by a genetic test. Antiepileptic drugs (AED) (vigabatrin in 7 patients, valproic acid in 7 patients and levetiracetam in 2 patients) were administered after detection of epileptiform activity in the routine EEG (EEG was performed monthly).Results. Preventive therapy with valproic acid and levetiracetam was found to be ineffective: 4 out of 7 patients on valproic acid and 1 out of 2 patients on levetiracetam developed epilepsy. All of them were later diagnosed with delayed psychological development and delayed speech development. Among 7 patients receiving vigabatrin, only 1 patient developed epilepsy, but did not have any developmental disorders later.Conclusion. Despite vigabatrin is not registered in the Russian Federation, it should be used as an agent for preventive antiepileptic therapy in patients with TS. This approach ensures more favorable long-term results in terms of cognitive functions and psychological development, thus, providing a better quality of life.https://rjdn.abvpress.ru/jour/article/view/210эпилепсиятуберозный склероздетивигабатринпревентивная терапия |
| spellingShingle | A. V. Grigoryeva M. Yu. Dorofeeva Z. K. Gorchkhanova V. S. Perminov E. D. Belousova PREVENTIVE ANTIEPILEPTIC THERAPY IN PATIENTS WITH TUBEROUS SCLEROSIS Русский журнал детской неврологии эпилепсия туберозный склероз дети вигабатрин превентивная терапия |
| title | PREVENTIVE ANTIEPILEPTIC THERAPY IN PATIENTS WITH TUBEROUS SCLEROSIS |
| title_full | PREVENTIVE ANTIEPILEPTIC THERAPY IN PATIENTS WITH TUBEROUS SCLEROSIS |
| title_fullStr | PREVENTIVE ANTIEPILEPTIC THERAPY IN PATIENTS WITH TUBEROUS SCLEROSIS |
| title_full_unstemmed | PREVENTIVE ANTIEPILEPTIC THERAPY IN PATIENTS WITH TUBEROUS SCLEROSIS |
| title_short | PREVENTIVE ANTIEPILEPTIC THERAPY IN PATIENTS WITH TUBEROUS SCLEROSIS |
| title_sort | preventive antiepileptic therapy in patients with tuberous sclerosis |
| topic | эпилепсия туберозный склероз дети вигабатрин превентивная терапия |
| url | https://rjdn.abvpress.ru/jour/article/view/210 |
| work_keys_str_mv | AT avgrigoryeva preventiveantiepileptictherapyinpatientswithtuberoussclerosis AT myudorofeeva preventiveantiepileptictherapyinpatientswithtuberoussclerosis AT zkgorchkhanova preventiveantiepileptictherapyinpatientswithtuberoussclerosis AT vsperminov preventiveantiepileptictherapyinpatientswithtuberoussclerosis AT edbelousova preventiveantiepileptictherapyinpatientswithtuberoussclerosis |