Scope of nanotechnology in ovarian cancer therapeutics
<p>Abstract</p> <p>This review describes the use of polymer micelle nanotechnology based chemotherapies for ovarian cancer. While various chemotherapeutic agents can be utilized to improve the survival rate of patients with ovarian cancer, their distribution throughout the entire b...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-08-01
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| Series: | Journal of Ovarian Research |
| Online Access: | http://www.ovarianresearch.com/content/3/1/19 |
| _version_ | 1828082664348844032 |
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| author | Yallapu Murali M Jaggi Meena Chauhan Subhash C |
| author_facet | Yallapu Murali M Jaggi Meena Chauhan Subhash C |
| author_sort | Yallapu Murali M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>This review describes the use of polymer micelle nanotechnology based chemotherapies for ovarian cancer. While various chemotherapeutic agents can be utilized to improve the survival rate of patients with ovarian cancer, their distribution throughout the entire body results in high normal organ toxicity. Polymer micelle nanotechnology aims to improve the therapeutic efficacy of anti-cancer drugs while minimizing the side effects. Herein, different types of polymer micelle technology based nanotherapies such as PLGA, polymerosomes, acid cleavable, thermosensitive, pH sensitive, and cross-linked micelles are introduced and structural differences are explained. Additionally, production methods, stability, sustainability, drug incorporation and drug release profiles of various polymer micelle based nanoformulations are discussed. An important feature of polymer micelle nanotechnology is the small size (10-100 nm) of particles which improves circulation and enables superior accumulation of the therapeutic drugs at the tumor sites. This review provides a comprehensive evaluation of different types of polymer micelles and their implications in ovarian cancer therapeutics.</p> |
| first_indexed | 2024-04-11T03:55:32Z |
| format | Article |
| id | doaj.art-b71695aecdd0475cb78c34ad6c1e8ac5 |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T03:55:32Z |
| publishDate | 2010-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-b71695aecdd0475cb78c34ad6c1e8ac52023-01-02T00:45:53ZengBMCJournal of Ovarian Research1757-22152010-08-01311910.1186/1757-2215-3-19Scope of nanotechnology in ovarian cancer therapeuticsYallapu Murali MJaggi MeenaChauhan Subhash C<p>Abstract</p> <p>This review describes the use of polymer micelle nanotechnology based chemotherapies for ovarian cancer. While various chemotherapeutic agents can be utilized to improve the survival rate of patients with ovarian cancer, their distribution throughout the entire body results in high normal organ toxicity. Polymer micelle nanotechnology aims to improve the therapeutic efficacy of anti-cancer drugs while minimizing the side effects. Herein, different types of polymer micelle technology based nanotherapies such as PLGA, polymerosomes, acid cleavable, thermosensitive, pH sensitive, and cross-linked micelles are introduced and structural differences are explained. Additionally, production methods, stability, sustainability, drug incorporation and drug release profiles of various polymer micelle based nanoformulations are discussed. An important feature of polymer micelle nanotechnology is the small size (10-100 nm) of particles which improves circulation and enables superior accumulation of the therapeutic drugs at the tumor sites. This review provides a comprehensive evaluation of different types of polymer micelles and their implications in ovarian cancer therapeutics.</p>http://www.ovarianresearch.com/content/3/1/19 |
| spellingShingle | Yallapu Murali M Jaggi Meena Chauhan Subhash C Scope of nanotechnology in ovarian cancer therapeutics Journal of Ovarian Research |
| title | Scope of nanotechnology in ovarian cancer therapeutics |
| title_full | Scope of nanotechnology in ovarian cancer therapeutics |
| title_fullStr | Scope of nanotechnology in ovarian cancer therapeutics |
| title_full_unstemmed | Scope of nanotechnology in ovarian cancer therapeutics |
| title_short | Scope of nanotechnology in ovarian cancer therapeutics |
| title_sort | scope of nanotechnology in ovarian cancer therapeutics |
| url | http://www.ovarianresearch.com/content/3/1/19 |
| work_keys_str_mv | AT yallapumuralim scopeofnanotechnologyinovariancancertherapeutics AT jaggimeena scopeofnanotechnologyinovariancancertherapeutics AT chauhansubhashc scopeofnanotechnologyinovariancancertherapeutics |