Neuropsychological decrements in midlife type-2 diabetes are not associated with peripheral NLRP3 inflammasome responsiveness

Neuropsychological decrements in midlife type-2 diabetes are not associated with peripheral NLRP3 inflammasome responsiveness

Midlife Type 2 Diabetes Mellitus (T2DM) is associated with an increased risk of Alzheimer Disease (AD) in later life, with altered inflammatory responses postulated as key pathological drivers. Previous studies have demonstrated increased responsiveness to NLR family pyrin domain containing 3 (NLRP3...

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Bibliographic Details
Main Authors: Adam H. Dyer, Isabella Batten, Conor Reddy, Liam Townsend, Conor P. Woods, Desmond O’Neill, James Gibney, Sean P. Kennelly, Nollaig M. Bourke
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
diabetes
cognition
dementia
inflammation
midlife
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1021351/full

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