Glyphosate escalates horizontal transfer of conjugative plasmid harboring antibiotic resistance genes
Glyphosate has been frequently detected in water environments because of the wide use for controlling weed in farm lands and urban areas. Presently, the focus of the majority of studies is placed on the toxicity of glyphosate on humans and animals. However, the effects of glyphosate on horizontal tr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-01-01
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| Series: | Bioengineered |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21655979.2020.1862995 |
| _version_ | 1798034138234617856 |
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| author | Hongna Zhang Jingbo Liu Lei Wang Zhenzhen Zhai |
| author_facet | Hongna Zhang Jingbo Liu Lei Wang Zhenzhen Zhai |
| author_sort | Hongna Zhang |
| collection | DOAJ |
| description | Glyphosate has been frequently detected in water environments because of the wide use for controlling weed in farm lands and urban areas. Presently, the focus of the majority of studies is placed on the toxicity of glyphosate on humans and animals. However, the effects of glyphosate on horizontal transfer of conjugative plasmid carrying antibiotic resistance gene (ARG) are largely unknown. Here, we explored the ability and potential mechanism of glyphosate for accelerating horizontal transfer of conjugative plasmid-mediated ARG. The results showed that glyphosate can effectively boost horizontal transfer rate of conjugative plasmid carrying ARG. The possible mechanism analysis demonstrated that over-production of reactive oxygen species and reactive nitrogen species effectively regulated expression levels of bacterial outer membrane protein and conjugative transfer-related genes, thereby resulting into elevated horizontal transfer rate of plasmid-mediated ARG. In conclusion, this study casts new understanding into the biological effects of glyphosate on ARG. |
| first_indexed | 2024-04-11T20:40:05Z |
| format | Article |
| id | doaj.art-b7171093e7644c0a8b21f4a94f55acc9 |
| institution | Directory Open Access Journal |
| issn | 2165-5979 2165-5987 |
| language | English |
| last_indexed | 2024-04-11T20:40:05Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Bioengineered |
| spelling | doaj.art-b7171093e7644c0a8b21f4a94f55acc92022-12-22T04:04:15ZengTaylor & Francis GroupBioengineered2165-59792165-59872021-01-01121636910.1080/21655979.2020.18629951862995Glyphosate escalates horizontal transfer of conjugative plasmid harboring antibiotic resistance genesHongna Zhang0Jingbo Liu1Lei Wang2Zhenzhen Zhai3Hebei University of Economics and BusinessShandong Agricultural UniversityThe Second Children & Women’s Healthcare Center of Jinan CityTai’an City Central HospitalGlyphosate has been frequently detected in water environments because of the wide use for controlling weed in farm lands and urban areas. Presently, the focus of the majority of studies is placed on the toxicity of glyphosate on humans and animals. However, the effects of glyphosate on horizontal transfer of conjugative plasmid carrying antibiotic resistance gene (ARG) are largely unknown. Here, we explored the ability and potential mechanism of glyphosate for accelerating horizontal transfer of conjugative plasmid-mediated ARG. The results showed that glyphosate can effectively boost horizontal transfer rate of conjugative plasmid carrying ARG. The possible mechanism analysis demonstrated that over-production of reactive oxygen species and reactive nitrogen species effectively regulated expression levels of bacterial outer membrane protein and conjugative transfer-related genes, thereby resulting into elevated horizontal transfer rate of plasmid-mediated ARG. In conclusion, this study casts new understanding into the biological effects of glyphosate on ARG.http://dx.doi.org/10.1080/21655979.2020.1862995glyphosatereactive oxygen speciesreactive nitrogen speciesantibiotic resistance genehorizontal transfer |
| spellingShingle | Hongna Zhang Jingbo Liu Lei Wang Zhenzhen Zhai Glyphosate escalates horizontal transfer of conjugative plasmid harboring antibiotic resistance genes Bioengineered glyphosate reactive oxygen species reactive nitrogen species antibiotic resistance gene horizontal transfer |
| title | Glyphosate escalates horizontal transfer of conjugative plasmid harboring antibiotic resistance genes |
| title_full | Glyphosate escalates horizontal transfer of conjugative plasmid harboring antibiotic resistance genes |
| title_fullStr | Glyphosate escalates horizontal transfer of conjugative plasmid harboring antibiotic resistance genes |
| title_full_unstemmed | Glyphosate escalates horizontal transfer of conjugative plasmid harboring antibiotic resistance genes |
| title_short | Glyphosate escalates horizontal transfer of conjugative plasmid harboring antibiotic resistance genes |
| title_sort | glyphosate escalates horizontal transfer of conjugative plasmid harboring antibiotic resistance genes |
| topic | glyphosate reactive oxygen species reactive nitrogen species antibiotic resistance gene horizontal transfer |
| url | http://dx.doi.org/10.1080/21655979.2020.1862995 |
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