Association of serum lipoproteins and inflammatory parameters derived from the blood test with renal function in COVID-19 outpatients
Abstract Changes in lipoprotein metabolism are among the main causes of hemodynamic impairment in renal function. COVID-19 is an multisystemic inflammatory disease, aggravating this situation. This cross-sectional study investigated the relationship of serum lipoprotein profile with inflammatory par...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universidade de São Paulo
2023-11-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502023000100429&tlng=en |
| _version_ | 1797635131060518912 |
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| author | Glautemberg de Almeida Viana Mac Dionys Rodrigues da Costa Mateus Edson da Silva Victória da Costa Silva Arif Ali Erlânia Alves de Siqueira Renata de Sousa Alves Alice Maria Costa Martins Ramon Róseo Paula Pessoa Bezerra de Menezes Maria Goretti Rodrigues de Queiroz Tiago Lima Sampaio |
| author_facet | Glautemberg de Almeida Viana Mac Dionys Rodrigues da Costa Mateus Edson da Silva Victória da Costa Silva Arif Ali Erlânia Alves de Siqueira Renata de Sousa Alves Alice Maria Costa Martins Ramon Róseo Paula Pessoa Bezerra de Menezes Maria Goretti Rodrigues de Queiroz Tiago Lima Sampaio |
| author_sort | Glautemberg de Almeida Viana |
| collection | DOAJ |
| description | Abstract Changes in lipoprotein metabolism are among the main causes of hemodynamic impairment in renal function. COVID-19 is an multisystemic inflammatory disease, aggravating this situation. This cross-sectional study investigated the relationship of serum lipoprotein profile with inflammatory parameters and renal function in 95 COVID-19 outpatients in comparison with 173 with flu-like symptoms. Serum samples were collected for the determination of total cholesterol and fractions, apolipoproteins (Apo A-I and Apo B), urea (sUr) and creatinine (sCr). The glomerular filtration rate (eGFR) was calculated. Neutrophil/lymphocyte (NLR) and platelet/lymphocyte (PLR) ratios were calculated as inflammatory parameters derived from the blood tests. COVID-19 patients presented lower high-density lipoprotein cholesterol (HDL-c) (47.90 ± 1.543 vs. 51.40 ± 0.992) and higher PLR (190.9 ± 9.410 vs. 137.6 ± 5.534) and NLR (3.40 ± 0.22 vs. 2.80 ± 0.15). Both NLR and PLR correlated with each other (r = 0.639). Furthermore, the Apo B/Apo A-I ratio was correlated with PLR (r = 0.5818) and eGFR (r = -0.2630). COVID-19 patients classified as at high risk of developing acute myocardial infarction based on the Apo B/ Apo A-I ratio had higher values for sUr/sCr. Thus, serum apolipoproteins, PLR, and NLR could be related to renal dysfunction in COVID-19. |
| first_indexed | 2024-03-11T12:16:58Z |
| format | Article |
| id | doaj.art-b717fa152efc4a8b91a48b12daad507b |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-03-11T12:16:58Z |
| publishDate | 2023-11-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-b717fa152efc4a8b91a48b12daad507b2023-11-07T07:44:38ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902023-11-015910.1590/s2175-97902023e23293Association of serum lipoproteins and inflammatory parameters derived from the blood test with renal function in COVID-19 outpatientsGlautemberg de Almeida VianaMac Dionys Rodrigues da CostaMateus Edson da SilvaVictória da Costa SilvaArif AliErlânia Alves de SiqueiraRenata de Sousa AlvesAlice Maria Costa MartinsRamon Róseo Paula Pessoa Bezerra de MenezesMaria Goretti Rodrigues de QueirozTiago Lima Sampaiohttps://orcid.org/0000-0002-3962-6508Abstract Changes in lipoprotein metabolism are among the main causes of hemodynamic impairment in renal function. COVID-19 is an multisystemic inflammatory disease, aggravating this situation. This cross-sectional study investigated the relationship of serum lipoprotein profile with inflammatory parameters and renal function in 95 COVID-19 outpatients in comparison with 173 with flu-like symptoms. Serum samples were collected for the determination of total cholesterol and fractions, apolipoproteins (Apo A-I and Apo B), urea (sUr) and creatinine (sCr). The glomerular filtration rate (eGFR) was calculated. Neutrophil/lymphocyte (NLR) and platelet/lymphocyte (PLR) ratios were calculated as inflammatory parameters derived from the blood tests. COVID-19 patients presented lower high-density lipoprotein cholesterol (HDL-c) (47.90 ± 1.543 vs. 51.40 ± 0.992) and higher PLR (190.9 ± 9.410 vs. 137.6 ± 5.534) and NLR (3.40 ± 0.22 vs. 2.80 ± 0.15). Both NLR and PLR correlated with each other (r = 0.639). Furthermore, the Apo B/Apo A-I ratio was correlated with PLR (r = 0.5818) and eGFR (r = -0.2630). COVID-19 patients classified as at high risk of developing acute myocardial infarction based on the Apo B/ Apo A-I ratio had higher values for sUr/sCr. Thus, serum apolipoproteins, PLR, and NLR could be related to renal dysfunction in COVID-19.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502023000100429&tlng=enSARS-CoV-2ApolipoproteinsGlomerular filtration rate |
| spellingShingle | Glautemberg de Almeida Viana Mac Dionys Rodrigues da Costa Mateus Edson da Silva Victória da Costa Silva Arif Ali Erlânia Alves de Siqueira Renata de Sousa Alves Alice Maria Costa Martins Ramon Róseo Paula Pessoa Bezerra de Menezes Maria Goretti Rodrigues de Queiroz Tiago Lima Sampaio Association of serum lipoproteins and inflammatory parameters derived from the blood test with renal function in COVID-19 outpatients Brazilian Journal of Pharmaceutical Sciences SARS-CoV-2 Apolipoproteins Glomerular filtration rate |
| title | Association of serum lipoproteins and inflammatory parameters derived from the blood test with renal function in COVID-19 outpatients |
| title_full | Association of serum lipoproteins and inflammatory parameters derived from the blood test with renal function in COVID-19 outpatients |
| title_fullStr | Association of serum lipoproteins and inflammatory parameters derived from the blood test with renal function in COVID-19 outpatients |
| title_full_unstemmed | Association of serum lipoproteins and inflammatory parameters derived from the blood test with renal function in COVID-19 outpatients |
| title_short | Association of serum lipoproteins and inflammatory parameters derived from the blood test with renal function in COVID-19 outpatients |
| title_sort | association of serum lipoproteins and inflammatory parameters derived from the blood test with renal function in covid 19 outpatients |
| topic | SARS-CoV-2 Apolipoproteins Glomerular filtration rate |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502023000100429&tlng=en |
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