Multiplexed MRM-based proteomics for identification of circulating proteins as biomarkers of cardiovascular damage progression associated with diabetes mellitus

Multiplexed MRM-based proteomics for identification of circulating proteins as biomarkers of cardiovascular damage progression associated with diabetes mellitus

Abstract Background Type 2 diabetes mellitus (T2DM) increases the risk of coronary heart disease (CHD) by 2–4 fold, and is associated with endothelial dysfunction, dyslipidaemia, insulin resistance, and chronic hyperglycaemia. The aim of this investigation was to assess, by a multimarker mass spectr...

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Bibliographic Details
Main Authors: Francesco Piarulli, Cristina Banfi, Eugenio Ragazzi, Erica Gianazza, Marco Munno, Massimo Carollo, Pietro Traldi, Annunziata Lapolla, Giovanni Sartore
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cardiovascular Diabetology
Subjects:
Proteomics
Blood proteins
Diabetes mellitus
Cardiovascular disease
Mass spectrometry
Multiple reaction monitoring
Online Access:https://doi.org/10.1186/s12933-024-02125-1

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