Tackling HLA Deficiencies Head on with Oncolytic Viruses
Dysregulation of HLA (human leukocyte antigen) function is increasingly recognized as a common escape mechanism for cancers subject to the pressures exerted by immunosurveillance or immunotherapeutic interventions. Oncolytic viruses have the potential to counter this resistance by upregulating HLA e...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/4/719 |
| _version_ | 1797411920145285120 |
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| author | Kerry Fisher Ahmet Hazini Leonard W. Seymour |
| author_facet | Kerry Fisher Ahmet Hazini Leonard W. Seymour |
| author_sort | Kerry Fisher |
| collection | DOAJ |
| description | Dysregulation of HLA (human leukocyte antigen) function is increasingly recognized as a common escape mechanism for cancers subject to the pressures exerted by immunosurveillance or immunotherapeutic interventions. Oncolytic viruses have the potential to counter this resistance by upregulating HLA expression or encouraging an HLA-independent immunological responses. However, to achieve the best therapeutic outcomes, a prospective understanding of the HLA phenotype of cancer patients is required to match them to the characteristics of different oncolytic strategies. Here, we consider the spectrum of immune competence observed in clinical disease and discuss how it can be best addressed using this novel and powerful treatment approach. |
| first_indexed | 2024-03-09T04:53:19Z |
| format | Article |
| id | doaj.art-b7185bd4d1ba4f758c02c595f14fcffc |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T04:53:19Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b7185bd4d1ba4f758c02c595f14fcffc2023-12-03T13:08:22ZengMDPI AGCancers2072-66942021-02-0113471910.3390/cancers13040719Tackling HLA Deficiencies Head on with Oncolytic VirusesKerry Fisher0Ahmet Hazini1Leonard W. Seymour2Department of Oncology, University of Oxford, Oxford OX3 7DQ, UKDepartment of Oncology, University of Oxford, Oxford OX3 7DQ, UKDepartment of Oncology, University of Oxford, Oxford OX3 7DQ, UKDysregulation of HLA (human leukocyte antigen) function is increasingly recognized as a common escape mechanism for cancers subject to the pressures exerted by immunosurveillance or immunotherapeutic interventions. Oncolytic viruses have the potential to counter this resistance by upregulating HLA expression or encouraging an HLA-independent immunological responses. However, to achieve the best therapeutic outcomes, a prospective understanding of the HLA phenotype of cancer patients is required to match them to the characteristics of different oncolytic strategies. Here, we consider the spectrum of immune competence observed in clinical disease and discuss how it can be best addressed using this novel and powerful treatment approach.https://www.mdpi.com/2072-6694/13/4/719oncolytic virusclass I HLAimmunosurveillanceimmunotherapy |
| spellingShingle | Kerry Fisher Ahmet Hazini Leonard W. Seymour Tackling HLA Deficiencies Head on with Oncolytic Viruses Cancers oncolytic virus class I HLA immunosurveillance immunotherapy |
| title | Tackling HLA Deficiencies Head on with Oncolytic Viruses |
| title_full | Tackling HLA Deficiencies Head on with Oncolytic Viruses |
| title_fullStr | Tackling HLA Deficiencies Head on with Oncolytic Viruses |
| title_full_unstemmed | Tackling HLA Deficiencies Head on with Oncolytic Viruses |
| title_short | Tackling HLA Deficiencies Head on with Oncolytic Viruses |
| title_sort | tackling hla deficiencies head on with oncolytic viruses |
| topic | oncolytic virus class I HLA immunosurveillance immunotherapy |
| url | https://www.mdpi.com/2072-6694/13/4/719 |
| work_keys_str_mv | AT kerryfisher tacklinghladeficienciesheadonwithoncolyticviruses AT ahmethazini tacklinghladeficienciesheadonwithoncolyticviruses AT leonardwseymour tacklinghladeficienciesheadonwithoncolyticviruses |