Antimüllerian Hormone Levels of Infants with Premature Thelarche

Objective:Antimüllerian hormone (AMH) concentrations in mini puberty are higher than those reported for the prepubertal period. In this study we investigated AMH concentrations in infants with premature thelarche (PT). A healthy control group was used for comparison.Methods:Forty five female infants...

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Main Authors: Nursel Muratoğlu Şahin, Elvan Bayramoğlu, Hatice Nursun Özcan, Erdal Kurnaz, Melikşah Keskin, Şenay Savaş-Erdeve, Semra Çetinkaya, Zehra Aycan
Format: Article
Language:English
Published: Galenos Yayincilik 2019-09-01
Series:JCRPE
Subjects:
Online Access: http://www.jcrpe.org/archives/archive-detail/article-preview/antimllerian-hormone-levels-of-nfants-with-prematu/25620
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author Nursel Muratoğlu Şahin
Elvan Bayramoğlu
Hatice Nursun Özcan
Erdal Kurnaz
Melikşah Keskin
Şenay Savaş-Erdeve
Semra Çetinkaya
Zehra Aycan
author_facet Nursel Muratoğlu Şahin
Elvan Bayramoğlu
Hatice Nursun Özcan
Erdal Kurnaz
Melikşah Keskin
Şenay Savaş-Erdeve
Semra Çetinkaya
Zehra Aycan
author_sort Nursel Muratoğlu Şahin
collection DOAJ
description Objective:Antimüllerian hormone (AMH) concentrations in mini puberty are higher than those reported for the prepubertal period. In this study we investigated AMH concentrations in infants with premature thelarche (PT). A healthy control group was used for comparison.Methods:Forty five female infants with PT, aged between one and three years and a control group consisting of 37 healthy girls in the same age range were included in the study. Bone age, pelvic ultrasonography, and concentrations of luteinizing hormone, follicle-stimulating hormone (FSH), estradiol and AMH of the patient group were evaluated. Only serum AMH concentration of the control group was evaluated.Results:Median (range) serum AMH concentrations in the subjects were 1.66 ng/mL (11.85 pmol/L) [0.15-6.32 ng/mL (1.07-45.12 pmol/L)] and were significantly lower (p=0.025) than for the control group; 1.96 ng/mL (13.99 pmol/L) [0.60-8.49 ng/mL (4.28-60.64 pmol/L)]. AMH and FSH were negatively correlated (r=-0.360, p=0.015) in infants with PT. There was no correlation between AMH and uterine size, uterine volume, endometrial thickness, fundocervical ratio, ovarian size or volume, follicle size and follicle number.Conclusion:This is the first study that investigates AMH concentrations in infants with PT. The low AMH levels in these infants and the negative correlation between AMH and FSH suggests that AMH may play a role in suppressing pubertal findings during infancy and that decreased AMH may cause PT in infancy.
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spelling doaj.art-b718f12a043c46d6a598ec00a75877c92023-02-15T16:07:17ZengGalenos YayincilikJCRPE1308-57271308-57352019-09-0111328729210.4274/jcrpe.galenos.2019.2018.029313049054Antimüllerian Hormone Levels of Infants with Premature ThelarcheNursel Muratoğlu Şahin0Elvan Bayramoğlu1Hatice Nursun Özcan2Erdal Kurnaz3Melikşah Keskin4Şenay Savaş-Erdeve5Semra Çetinkaya6Zehra Aycan7 Pediatric Health and Disease Training and Research Hospital, Dr. Sami Ulus Obstetrics and Gynecology, Clinic of Pediatric Endocrinology, Ankara, Turkey Pediatric Health and Disease Training and Research Hospital, Dr. Sami Ulus Obstetrics and Gynecology, Clinic of Pediatric Endocrinology, Ankara, Turkey Pediatric Health and Disease Training and Research Hospital, Dr. Sami Ulus Obstetrics and Gynecology, Clinic of Pediatric Radiology, Ankara, Turkey Pediatric Health and Disease Training and Research Hospital, Dr. Sami Ulus Obstetrics and Gynecology, Clinic of Pediatric Endocrinology, Ankara, Turkey Pediatric Health and Disease Training and Research Hospital, Dr. Sami Ulus Obstetrics and Gynecology, Clinic of Pediatric Endocrinology, Ankara, Turkey Pediatric Health and Disease Training and Research Hospital, Dr. Sami Ulus Obstetrics and Gynecology, Clinic of Pediatric Endocrinology, Ankara, Turkey Pediatric Health and Disease Training and Research Hospital, Dr. Sami Ulus Obstetrics and Gynecology, Clinic of Pediatric Endocrinology, Ankara, Turkey Pediatric Health and Disease Training and Research Hospital, Dr. Sami Ulus Obstetrics and Gynecology, Clinic of Pediatric Endocrinology, Ankara, Turkey Objective:Antimüllerian hormone (AMH) concentrations in mini puberty are higher than those reported for the prepubertal period. In this study we investigated AMH concentrations in infants with premature thelarche (PT). A healthy control group was used for comparison.Methods:Forty five female infants with PT, aged between one and three years and a control group consisting of 37 healthy girls in the same age range were included in the study. Bone age, pelvic ultrasonography, and concentrations of luteinizing hormone, follicle-stimulating hormone (FSH), estradiol and AMH of the patient group were evaluated. Only serum AMH concentration of the control group was evaluated.Results:Median (range) serum AMH concentrations in the subjects were 1.66 ng/mL (11.85 pmol/L) [0.15-6.32 ng/mL (1.07-45.12 pmol/L)] and were significantly lower (p=0.025) than for the control group; 1.96 ng/mL (13.99 pmol/L) [0.60-8.49 ng/mL (4.28-60.64 pmol/L)]. AMH and FSH were negatively correlated (r=-0.360, p=0.015) in infants with PT. There was no correlation between AMH and uterine size, uterine volume, endometrial thickness, fundocervical ratio, ovarian size or volume, follicle size and follicle number.Conclusion:This is the first study that investigates AMH concentrations in infants with PT. The low AMH levels in these infants and the negative correlation between AMH and FSH suggests that AMH may play a role in suppressing pubertal findings during infancy and that decreased AMH may cause PT in infancy. http://www.jcrpe.org/archives/archive-detail/article-preview/antimllerian-hormone-levels-of-nfants-with-prematu/25620 AMHpremature thelarcheinfancymini-puberty
spellingShingle Nursel Muratoğlu Şahin
Elvan Bayramoğlu
Hatice Nursun Özcan
Erdal Kurnaz
Melikşah Keskin
Şenay Savaş-Erdeve
Semra Çetinkaya
Zehra Aycan
Antimüllerian Hormone Levels of Infants with Premature Thelarche
JCRPE
AMH
premature thelarche
infancy
mini-puberty
title Antimüllerian Hormone Levels of Infants with Premature Thelarche
title_full Antimüllerian Hormone Levels of Infants with Premature Thelarche
title_fullStr Antimüllerian Hormone Levels of Infants with Premature Thelarche
title_full_unstemmed Antimüllerian Hormone Levels of Infants with Premature Thelarche
title_short Antimüllerian Hormone Levels of Infants with Premature Thelarche
title_sort antimullerian hormone levels of infants with premature thelarche
topic AMH
premature thelarche
infancy
mini-puberty
url http://www.jcrpe.org/archives/archive-detail/article-preview/antimllerian-hormone-levels-of-nfants-with-prematu/25620
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AT haticenursunozcan antimullerianhormonelevelsofinfantswithprematurethelarche
AT erdalkurnaz antimullerianhormonelevelsofinfantswithprematurethelarche
AT meliksahkeskin antimullerianhormonelevelsofinfantswithprematurethelarche
AT senaysavaserdeve antimullerianhormonelevelsofinfantswithprematurethelarche
AT semracetinkaya antimullerianhormonelevelsofinfantswithprematurethelarche
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