Downregulation of CCL22 and mutated NOTCH1 in tongue and mouth floor squamous cell carcinoma results in decreased Th2 cell recruitment and expression, predicting poor clinical outcome

Downregulation of CCL22 and mutated NOTCH1 in tongue and mouth floor squamous cell carcinoma results in decreased Th2 cell recruitment and expression, predicting poor clinical outcome

Abstract Objective Tongue and mouth floor squamous cell carcinoma (T/MF SCC) exhibits a high rate of local recurrence and cervical lymph node metastasis. The effect of the tumor microenvironment on T/MF SCC remains unclear. Materials and methods Transcriptome and somatic mutation data of patients wi...

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Bibliographic Details
Main Authors: Xuejie Li, Zheqi Liu, Wenkai Zhou, Xiaofang Liu, Wei Cao
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Cancer
Subjects:
Tongue and mouth floor SCC
Th2 cells
CCL22
NOTCH1
TCGA
Online Access:https://doi.org/10.1186/s12885-021-08671-1

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