| Summary: | American scientists David Julius and Ardem Patapoutian won the Nobel Prize in physiology or medicine in 2021 for their groundbreaking discoveries of capsaicin receptor TRPV1 and menthol receptor TRPM8, revealing the secrets of temperature perception. The outstanding discovery of capsaicin receptor TRPV1 and cold sensitive receptor TRPM8 has deepened our understanding on perception and adapt to the surrounding environment. However, thermal sensitive hot channel TRPV1 and cold channel TRPM8 are not only expressed abundantly in the nervous system, but also exist in the cardiovascular, fat, liver, skeletal muscle and other tissues and organs, and their biological significance remain elusive. In the past 30 years, much evidence shows that TRPV1 and TRPM8 not only perceive changes in environmental temperature, but also have rich biological effects, such as pain sensation, inflammatory response, and so on. Studies concerning the role of transient receptor potential (TRP) channels in the body homeostasis and its association with disease continue to grow and deepen. Since 2004, our team has introduced TRP channels into cardiovascular and metabolic fields and revealed their roles and mechanisms in cardiovascular and metabolic diseases. It is expected that this year's Nobel Prize award will further promote the development of temperature-sensitive channel proteins in cardiovascular and metabolic field.
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