Effects of KP-496, a Novel Dual Antagonist for Leukotriene D4 and Thromboxane A2 Receptors, on Contractions Induced by Various Agonists in the Guinea Pig Trachea

Effects of KP-496, a Novel Dual Antagonist for Leukotriene D4 and Thromboxane A2 Receptors, on Contractions Induced by Various Agonists in the Guinea Pig Trachea

Background: A dry powder inhaler of KP-496 is currently in clinical development in Japan as an antiasthmatic agent. The aim of this study was to evaluate the in vitro pharmacological profile of KP-496. Methods: The antagonistic activities of KP-496 for leukotriene (Lt) D4 and thromboxane (TX) A2 rec...

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Bibliographic Details
Main Authors: Masakazu Ishimura, Sayuri Kataoka, Masahiro Suda, Takashi Maeda, Yoshiyuki Hiyama
Format: Article
Language:English
Published: Elsevier 2006-01-01
Series:Allergology International
Subjects:
antagonist
anti-asthmatic drugs
asthma
leukotriene D4
thromboxane A2
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893015309965

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