Yijinjing Qigong intervention shows strong evidence on clinical effectiveness and electroencephalography signal features for early poststroke depression: A randomized, controlled trial
ObjectiveAlthough Traditional Chinese Yijinjing Qigong Exercise (YJJQE) as mind–body intervention is popularly used among adults to ameliorate depressive symptoms in China, no randomized controlled trials (RCTs) are available to evaluate the effects of YJJQE in patients with poststroke depression (P...
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.956316/full |
| _version_ | 1798037800000421888 |
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| author | Pingping Sun Shuaipan Zhang Shuaipan Zhang Linhong Jiang Zhenzhen Ma Chongjie Yao Chongjie Yao Qingguang Zhu Qingguang Zhu Min Fang Min Fang |
| author_facet | Pingping Sun Shuaipan Zhang Shuaipan Zhang Linhong Jiang Zhenzhen Ma Chongjie Yao Chongjie Yao Qingguang Zhu Qingguang Zhu Min Fang Min Fang |
| author_sort | Pingping Sun |
| collection | DOAJ |
| description | ObjectiveAlthough Traditional Chinese Yijinjing Qigong Exercise (YJJQE) as mind–body intervention is popularly used among adults to ameliorate depressive symptoms in China, no randomized controlled trials (RCTs) are available to evaluate the effects of YJJQE in patients with poststroke depression (PSD). This study aims to explore the clinical efficacy and the neurological and psychiatric mechanism in brain network functional connectivity underlying electroencephalography (EEG).Materials and methodsA total of 60 patients, diagnosed with mild PSD, were randomly (1:1) assigned to YJJQE group (n = 30) and control group of routine segmental rehabilitation training group (n = 30) for a 60-min exercise session once a day for 3 weeks. All outcome measures were collected at baseline and 3-weeks ending intervention. The primary outcome was the 24-item Hamilton Depression Scale (HAMD-24) score, evaluation at more time points for 1 month of follow-up. The secondary outcomes were EEG data in four frequency domains (δ, θ, α, and β), global efficiency (GE), local efficiency (LE), GE/LE curve [areas under the curve (AUC)], Phase Lag Index (PLI), (HAMD-24) Score and EEG correlation analysis.ResultsAll patients showed no significant differences in baseline data. After 3 weeks and 1 month of follow-up, the YJJQE group demonstrated significant decreasing changes compared to the control group on the HAMD-24 scores (p < 0.001). Furthermore, the YJJQE group also showed a significant reduction in θ wave, and an increase in both GE and LE. Compared to the control group, the YJJQE Qigong group showed significantly greater functional connectivity in the δ, θ, and β frequency bands in the brain network of the degree of phase synchronization (p < 0.001). HAMD-24 Score and EEG correlation analysis negative correlation in the Qigong group θ wave (p < 0.001).ConclusionOur findings demonstrated that YJJQE is estimated to effectively alleviate the depressed mood of patients with PSD by promoting the efficiency in information transmission of network functional connectivity and its integration ability in different brain regions. Therefore, the YJJQE would be useful as a non-pharmacological treatment to prevent PSD.Clinical trial registration[http://www.chictr.org.cn/showproj.aspx?proj=55789], identifier [ChiCTR2000035588]. |
| first_indexed | 2024-04-11T21:31:30Z |
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| language | English |
| last_indexed | 2024-04-11T21:31:30Z |
| publishDate | 2022-08-01 |
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| spelling | doaj.art-b720c25ce13246478bdaae5fb9ec97192022-12-22T04:01:59ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-08-011410.3389/fnagi.2022.956316956316Yijinjing Qigong intervention shows strong evidence on clinical effectiveness and electroencephalography signal features for early poststroke depression: A randomized, controlled trialPingping Sun0Shuaipan Zhang1Shuaipan Zhang2Linhong Jiang3Zhenzhen Ma4Chongjie Yao5Chongjie Yao6Qingguang Zhu7Qingguang Zhu8Min Fang9Min Fang10School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaTuina Department, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaTuina Department, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaTuina Department, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Tuina Research, Research Institute of Traditional Chinese Medicine in Shanghai, Shanghai, ChinaTuina Department, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Tuina Research, Research Institute of Traditional Chinese Medicine in Shanghai, Shanghai, ChinaObjectiveAlthough Traditional Chinese Yijinjing Qigong Exercise (YJJQE) as mind–body intervention is popularly used among adults to ameliorate depressive symptoms in China, no randomized controlled trials (RCTs) are available to evaluate the effects of YJJQE in patients with poststroke depression (PSD). This study aims to explore the clinical efficacy and the neurological and psychiatric mechanism in brain network functional connectivity underlying electroencephalography (EEG).Materials and methodsA total of 60 patients, diagnosed with mild PSD, were randomly (1:1) assigned to YJJQE group (n = 30) and control group of routine segmental rehabilitation training group (n = 30) for a 60-min exercise session once a day for 3 weeks. All outcome measures were collected at baseline and 3-weeks ending intervention. The primary outcome was the 24-item Hamilton Depression Scale (HAMD-24) score, evaluation at more time points for 1 month of follow-up. The secondary outcomes were EEG data in four frequency domains (δ, θ, α, and β), global efficiency (GE), local efficiency (LE), GE/LE curve [areas under the curve (AUC)], Phase Lag Index (PLI), (HAMD-24) Score and EEG correlation analysis.ResultsAll patients showed no significant differences in baseline data. After 3 weeks and 1 month of follow-up, the YJJQE group demonstrated significant decreasing changes compared to the control group on the HAMD-24 scores (p < 0.001). Furthermore, the YJJQE group also showed a significant reduction in θ wave, and an increase in both GE and LE. Compared to the control group, the YJJQE Qigong group showed significantly greater functional connectivity in the δ, θ, and β frequency bands in the brain network of the degree of phase synchronization (p < 0.001). HAMD-24 Score and EEG correlation analysis negative correlation in the Qigong group θ wave (p < 0.001).ConclusionOur findings demonstrated that YJJQE is estimated to effectively alleviate the depressed mood of patients with PSD by promoting the efficiency in information transmission of network functional connectivity and its integration ability in different brain regions. Therefore, the YJJQE would be useful as a non-pharmacological treatment to prevent PSD.Clinical trial registration[http://www.chictr.org.cn/showproj.aspx?proj=55789], identifier [ChiCTR2000035588].https://www.frontiersin.org/articles/10.3389/fnagi.2022.956316/fullpoststroke depressiontraditional exerciseYijinjing Qigong exerciseEEGbrain functional connectivity network |
| spellingShingle | Pingping Sun Shuaipan Zhang Shuaipan Zhang Linhong Jiang Zhenzhen Ma Chongjie Yao Chongjie Yao Qingguang Zhu Qingguang Zhu Min Fang Min Fang Yijinjing Qigong intervention shows strong evidence on clinical effectiveness and electroencephalography signal features for early poststroke depression: A randomized, controlled trial Frontiers in Aging Neuroscience poststroke depression traditional exercise Yijinjing Qigong exercise EEG brain functional connectivity network |
| title | Yijinjing Qigong intervention shows strong evidence on clinical effectiveness and electroencephalography signal features for early poststroke depression: A randomized, controlled trial |
| title_full | Yijinjing Qigong intervention shows strong evidence on clinical effectiveness and electroencephalography signal features for early poststroke depression: A randomized, controlled trial |
| title_fullStr | Yijinjing Qigong intervention shows strong evidence on clinical effectiveness and electroencephalography signal features for early poststroke depression: A randomized, controlled trial |
| title_full_unstemmed | Yijinjing Qigong intervention shows strong evidence on clinical effectiveness and electroencephalography signal features for early poststroke depression: A randomized, controlled trial |
| title_short | Yijinjing Qigong intervention shows strong evidence on clinical effectiveness and electroencephalography signal features for early poststroke depression: A randomized, controlled trial |
| title_sort | yijinjing qigong intervention shows strong evidence on clinical effectiveness and electroencephalography signal features for early poststroke depression a randomized controlled trial |
| topic | poststroke depression traditional exercise Yijinjing Qigong exercise EEG brain functional connectivity network |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.956316/full |
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