IN ABSENCE OF THE CELLULAR PRION PROTEIN, ALTERATIONS IN COPPER METABOLISM AND COPPER-DEPENDENT OXIDASE ACTIVITY AFFECT IRON DISTRIBUTION

IN ABSENCE OF THE CELLULAR PRION PROTEIN, ALTERATIONS IN COPPER METABOLISM AND COPPER-DEPENDENT OXIDASE ACTIVITY AFFECT IRON DISTRIBUTION

Essential elements as copper and iron modulate a wide range of physiological functions. Their metabolism is strictly regulated by cellular pathways, since dysregulation of metal homeostasis is responsible for many detrimental effects. Neurodegenerative disorders such as Alzheimer’s disease, Parkinso...

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Bibliographic Details
Main Authors: Lisa Gasperini, Elisa Meneghetti, Giuseppe Legname, Federico Benetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Neuroscience
Subjects:
Copper
Iron
prion
Oxidase activity
Essential metals
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00437/full

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