NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunity
Despite advances in combined photothermal/immunotherapy of tumor, the therapeutic effect has been impaired due to hypoxic microenvironment and inadequate immune activation. Manganese ions directly activated the stimulator of interferon genes (STING) pathway and induced innate antitumor immunity. Her...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006423000261 |
| _version_ | 1797854352913727488 |
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| author | Qianzhe Li Mengyu Yang Xin Sun Qinxin Wang Beibei Yu Aihua Gong Miaomiao Zhang Fengyi Du |
| author_facet | Qianzhe Li Mengyu Yang Xin Sun Qinxin Wang Beibei Yu Aihua Gong Miaomiao Zhang Fengyi Du |
| author_sort | Qianzhe Li |
| collection | DOAJ |
| description | Despite advances in combined photothermal/immunotherapy of tumor, the therapeutic effect has been impaired due to hypoxic microenvironment and inadequate immune activation. Manganese ions directly activated the stimulator of interferon genes (STING) pathway and induced innate antitumor immunity. Herein, a near infrared light (NIR)-responsive nanoenzyme (PB–Mn/OVA NE) was constructed by doping manganese into the ovalbumin (OVA)-templated Prussian blue (PB) nanoparticles. The resultant PB-Mn/OVA NEs exhibited favorable catalase activity to produce oxygen, which was conducive to alleviate the tumor hypoxic microenvironment. Under 808 nm NIR irradiation, the PB-Mn/OVA NEs with outstanding photothermal conversion efficiency of 30% significantly destroyed tumor cells by inducing immunogenic cell death (ICD). Impressively, the PB-Mn/OVA NEs could activate the cGAS-STING pathway to promote the maturation and the antigen cross-presentation ability of dendritic cells (DCs), which further activated cytotoxic T lymphocytes and memory T lymphocytes. Overall, this work presents a powerful nanoenzyme formula to integrate photothermal ablation and hypoxic reversal for triggering robust innate and adaptive antitumor immune response. |
| first_indexed | 2024-04-09T20:04:34Z |
| format | Article |
| id | doaj.art-b72334df9913491a8792f2a4914d43a7 |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-04-09T20:04:34Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-b72334df9913491a8792f2a4914d43a72023-04-02T06:14:35ZengElsevierMaterials Today Bio2590-00642023-04-0119100566NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunityQianzhe Li0Mengyu Yang1Xin Sun2Qinxin Wang3Beibei Yu4Aihua Gong5Miaomiao Zhang6Fengyi Du7Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu University 212013, PR. China; Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, PR. ChinaJiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, PR. ChinaJiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, PR. ChinaJiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, PR. ChinaJiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, PR. ChinaJiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, PR. ChinaJiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, PR. ChinaDepartment of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu University 212013, PR. China; Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, PR. China; Corresponding author. Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu University 212013, PR. China.Despite advances in combined photothermal/immunotherapy of tumor, the therapeutic effect has been impaired due to hypoxic microenvironment and inadequate immune activation. Manganese ions directly activated the stimulator of interferon genes (STING) pathway and induced innate antitumor immunity. Herein, a near infrared light (NIR)-responsive nanoenzyme (PB–Mn/OVA NE) was constructed by doping manganese into the ovalbumin (OVA)-templated Prussian blue (PB) nanoparticles. The resultant PB-Mn/OVA NEs exhibited favorable catalase activity to produce oxygen, which was conducive to alleviate the tumor hypoxic microenvironment. Under 808 nm NIR irradiation, the PB-Mn/OVA NEs with outstanding photothermal conversion efficiency of 30% significantly destroyed tumor cells by inducing immunogenic cell death (ICD). Impressively, the PB-Mn/OVA NEs could activate the cGAS-STING pathway to promote the maturation and the antigen cross-presentation ability of dendritic cells (DCs), which further activated cytotoxic T lymphocytes and memory T lymphocytes. Overall, this work presents a powerful nanoenzyme formula to integrate photothermal ablation and hypoxic reversal for triggering robust innate and adaptive antitumor immune response.http://www.sciencedirect.com/science/article/pii/S2590006423000261Prussian bluePhotothermal therapyNanoenzymeHypoxic reversalcGAS-STING |
| spellingShingle | Qianzhe Li Mengyu Yang Xin Sun Qinxin Wang Beibei Yu Aihua Gong Miaomiao Zhang Fengyi Du NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunity Materials Today Bio Prussian blue Photothermal therapy Nanoenzyme Hypoxic reversal cGAS-STING |
| title | NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunity |
| title_full | NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunity |
| title_fullStr | NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunity |
| title_full_unstemmed | NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunity |
| title_short | NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunity |
| title_sort | nir responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the sting dependent innate antitumor immunity |
| topic | Prussian blue Photothermal therapy Nanoenzyme Hypoxic reversal cGAS-STING |
| url | http://www.sciencedirect.com/science/article/pii/S2590006423000261 |
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