Botulinum toxin injection changes resting state cerebellar connectivity in cervical dystonia
Abstract In cervical dystonia, functional MRI (fMRI) evidence indicates changes in several resting state networks, which revert in part following the botulinum neurotoxin A (BoNT) therapy. Recently, the involvement of the cerebellum in dystonia has gained attention. The aim of our study was to compa...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-87088-z |
| _version_ | 1818722829459259392 |
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| author | Pavel Hok Lenka Hvizdošová Pavel Otruba Michaela Kaiserová Markéta Trnečková Zbyněk Tüdös Petr Hluštík Petr Kaňovský Martin Nevrlý |
| author_facet | Pavel Hok Lenka Hvizdošová Pavel Otruba Michaela Kaiserová Markéta Trnečková Zbyněk Tüdös Petr Hluštík Petr Kaňovský Martin Nevrlý |
| author_sort | Pavel Hok |
| collection | DOAJ |
| description | Abstract In cervical dystonia, functional MRI (fMRI) evidence indicates changes in several resting state networks, which revert in part following the botulinum neurotoxin A (BoNT) therapy. Recently, the involvement of the cerebellum in dystonia has gained attention. The aim of our study was to compare connectivity between cerebellar subdivisions and the rest of the brain before and after BoNT treatment. Seventeen patients with cervical dystonia indicated for treatment with BoNT were enrolled (14 female, aged 50.2 ± 8.5 years, range 38–63 years). Clinical and fMRI examinations were carried out before and 4 weeks after BoNT injection. Clinical severity was evaluated using TWSTRS. Functional MRI data were acquired on a 1.5 T scanner during 8 min rest. Seed-based functional connectivity analysis was performed using data extracted from atlas-defined cerebellar areas in both datasets. Clinical scores demonstrated satisfactory BoNT effect. After treatment, connectivity decreased between the vermis lobule VIIIa and the left dorsal mesial frontal cortex. Positive correlations between the connectivity differences and the clinical improvement were detected for the right lobule VI, right crus II, vermis VIIIb and the right lobule IX. Our data provide evidence for modulation of cerebello-cortical connectivity resulting from successful treatment by botulinum neurotoxin. |
| first_indexed | 2024-12-17T21:00:51Z |
| format | Article |
| id | doaj.art-b7258ebea5c54213a9e8987f9a94e3fe |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T21:00:51Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b7258ebea5c54213a9e8987f9a94e3fe2022-12-21T21:32:44ZengNature PortfolioScientific Reports2045-23222021-04-0111111110.1038/s41598-021-87088-zBotulinum toxin injection changes resting state cerebellar connectivity in cervical dystoniaPavel Hok0Lenka Hvizdošová1Pavel Otruba2Michaela Kaiserová3Markéta Trnečková4Zbyněk Tüdös5Petr Hluštík6Petr Kaňovský7Martin Nevrlý8Department of Neurology, University Hospital OlomoucDepartment of Neurology, University Hospital OlomoucDepartment of Neurology, University Hospital OlomoucDepartment of Neurology, University Hospital OlomoucDepartment of Neurology, University Hospital OlomoucDepartment of Radiology, University Hospital OlomoucDepartment of Neurology, University Hospital OlomoucDepartment of Neurology, University Hospital OlomoucDepartment of Neurology, University Hospital OlomoucAbstract In cervical dystonia, functional MRI (fMRI) evidence indicates changes in several resting state networks, which revert in part following the botulinum neurotoxin A (BoNT) therapy. Recently, the involvement of the cerebellum in dystonia has gained attention. The aim of our study was to compare connectivity between cerebellar subdivisions and the rest of the brain before and after BoNT treatment. Seventeen patients with cervical dystonia indicated for treatment with BoNT were enrolled (14 female, aged 50.2 ± 8.5 years, range 38–63 years). Clinical and fMRI examinations were carried out before and 4 weeks after BoNT injection. Clinical severity was evaluated using TWSTRS. Functional MRI data were acquired on a 1.5 T scanner during 8 min rest. Seed-based functional connectivity analysis was performed using data extracted from atlas-defined cerebellar areas in both datasets. Clinical scores demonstrated satisfactory BoNT effect. After treatment, connectivity decreased between the vermis lobule VIIIa and the left dorsal mesial frontal cortex. Positive correlations between the connectivity differences and the clinical improvement were detected for the right lobule VI, right crus II, vermis VIIIb and the right lobule IX. Our data provide evidence for modulation of cerebello-cortical connectivity resulting from successful treatment by botulinum neurotoxin.https://doi.org/10.1038/s41598-021-87088-z |
| spellingShingle | Pavel Hok Lenka Hvizdošová Pavel Otruba Michaela Kaiserová Markéta Trnečková Zbyněk Tüdös Petr Hluštík Petr Kaňovský Martin Nevrlý Botulinum toxin injection changes resting state cerebellar connectivity in cervical dystonia Scientific Reports |
| title | Botulinum toxin injection changes resting state cerebellar connectivity in cervical dystonia |
| title_full | Botulinum toxin injection changes resting state cerebellar connectivity in cervical dystonia |
| title_fullStr | Botulinum toxin injection changes resting state cerebellar connectivity in cervical dystonia |
| title_full_unstemmed | Botulinum toxin injection changes resting state cerebellar connectivity in cervical dystonia |
| title_short | Botulinum toxin injection changes resting state cerebellar connectivity in cervical dystonia |
| title_sort | botulinum toxin injection changes resting state cerebellar connectivity in cervical dystonia |
| url | https://doi.org/10.1038/s41598-021-87088-z |
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