Investigating the Biosynthesis of Natural Products from Marine Proteobacteria: A Survey of Molecules and Strategies
The phylum proteobacteria contains a wide array of Gram-negative marine bacteria. With recent advances in genomic sequencing, genome analysis, and analytical chemistry techniques, a whole host of information is being revealed about the primary and secondary metabolism of marine proteobacteria. This...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-08-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/15/8/235 |
| _version_ | 1811308400050438144 |
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| author | Marshall L. Timmermans Yagya P. Paudel Avena C. Ross |
| author_facet | Marshall L. Timmermans Yagya P. Paudel Avena C. Ross |
| author_sort | Marshall L. Timmermans |
| collection | DOAJ |
| description | The phylum proteobacteria contains a wide array of Gram-negative marine bacteria. With recent advances in genomic sequencing, genome analysis, and analytical chemistry techniques, a whole host of information is being revealed about the primary and secondary metabolism of marine proteobacteria. This has led to the discovery of a growing number of medically relevant natural products, including novel leads for the treatment of multidrug-resistant Staphylococcus aureus (MRSA) and cancer. Of equal interest, marine proteobacteria produce natural products whose structure and biosynthetic mechanisms differ from those of their terrestrial and actinobacterial counterparts. Notable features of secondary metabolites produced by marine proteobacteria include halogenation, sulfur-containing heterocycles, non-ribosomal peptides, and polyketides with unusual biosynthetic logic. As advances are made in the technology associated with functional genomics, such as computational sequence analysis, targeted DNA manipulation, and heterologous expression, it has become easier to probe the mechanisms for natural product biosynthesis. This review will focus on genomics driven approaches to understanding the biosynthetic mechanisms for natural products produced by marine proteobacteria. |
| first_indexed | 2024-04-13T09:22:27Z |
| format | Article |
| id | doaj.art-b725d28067b34154bed5df1d693d4601 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-13T09:22:27Z |
| publishDate | 2017-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-b725d28067b34154bed5df1d693d46012022-12-22T02:52:33ZengMDPI AGMarine Drugs1660-33972017-08-0115823510.3390/md15080235md15080235Investigating the Biosynthesis of Natural Products from Marine Proteobacteria: A Survey of Molecules and StrategiesMarshall L. Timmermans0Yagya P. Paudel1Avena C. Ross2Department of Chemistry, Queen’s University, Kingston, ON K7L 3N6, CanadaDepartment of Chemistry, Queen’s University, Kingston, ON K7L 3N6, CanadaDepartment of Chemistry, Queen’s University, Kingston, ON K7L 3N6, CanadaThe phylum proteobacteria contains a wide array of Gram-negative marine bacteria. With recent advances in genomic sequencing, genome analysis, and analytical chemistry techniques, a whole host of information is being revealed about the primary and secondary metabolism of marine proteobacteria. This has led to the discovery of a growing number of medically relevant natural products, including novel leads for the treatment of multidrug-resistant Staphylococcus aureus (MRSA) and cancer. Of equal interest, marine proteobacteria produce natural products whose structure and biosynthetic mechanisms differ from those of their terrestrial and actinobacterial counterparts. Notable features of secondary metabolites produced by marine proteobacteria include halogenation, sulfur-containing heterocycles, non-ribosomal peptides, and polyketides with unusual biosynthetic logic. As advances are made in the technology associated with functional genomics, such as computational sequence analysis, targeted DNA manipulation, and heterologous expression, it has become easier to probe the mechanisms for natural product biosynthesis. This review will focus on genomics driven approaches to understanding the biosynthetic mechanisms for natural products produced by marine proteobacteria.https://www.mdpi.com/1660-3397/15/8/235biosynthesisproteobacterianatural productsgenomics |
| spellingShingle | Marshall L. Timmermans Yagya P. Paudel Avena C. Ross Investigating the Biosynthesis of Natural Products from Marine Proteobacteria: A Survey of Molecules and Strategies Marine Drugs biosynthesis proteobacteria natural products genomics |
| title | Investigating the Biosynthesis of Natural Products from Marine Proteobacteria: A Survey of Molecules and Strategies |
| title_full | Investigating the Biosynthesis of Natural Products from Marine Proteobacteria: A Survey of Molecules and Strategies |
| title_fullStr | Investigating the Biosynthesis of Natural Products from Marine Proteobacteria: A Survey of Molecules and Strategies |
| title_full_unstemmed | Investigating the Biosynthesis of Natural Products from Marine Proteobacteria: A Survey of Molecules and Strategies |
| title_short | Investigating the Biosynthesis of Natural Products from Marine Proteobacteria: A Survey of Molecules and Strategies |
| title_sort | investigating the biosynthesis of natural products from marine proteobacteria a survey of molecules and strategies |
| topic | biosynthesis proteobacteria natural products genomics |
| url | https://www.mdpi.com/1660-3397/15/8/235 |
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